THE A Comparative Review on Allium Sativum and Phyllanthus Emblica

  • Mukut Raj School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan
  • Girish Kumar Vyas School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan
  • Shailesh Sharma School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan
  • Hansraj Bishnoi School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

Abstract

Allium sativum and Phyllanthus emblica have the ability to treat a variety of disorders through diverse formulations. The goal of this comparative analysis is to assess the extractive properties of both plants in various solvents based on their polarity. I've noticed that ethanol has a high potential for extracting the API from the crude medicine, which may be emblica or sativum. As a result, additional assessment and research will be conducted with the consideration of plant potential and extractive production. This review article provides information about these plants, their common names, and their diverse activities in relation to various ailments.


 


 

Keywords: Allium sativum, Phyllanthus emblica, evaluation, extraction, crude drug etc

Downloads

Download data is not yet available.

Author Biographies

Mukut Raj, School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

Girish Kumar Vyas, School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

Shailesh Sharma, School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

Hansraj Bishnoi, School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

School of Pharmaceutical Studies, Faculty of Health Sciences, Dr. K. N. Modi University, Newai, Rajasthan

References

1. Kumar, M., Devi, H., Prakash, S., Rathore, S., Thakur, M., Puri, S., &Mekhemar, M. Ethnomedicinal plants used in the health care system: Survey of the mid hills of solan district, Himachal Pradesh, India. Plants, 2021; 10(9):1842.
2. Prakash, P., Kumar, M., Kumari, N., Prakash, S., Rathour, S., Thakur, M., ... &Mekhemar, M. (2021). Therapeutic uses of wild plants by rural inhabitants of Maraog region in district Shimla, Himachal pradesh, India. Horticulturae, 2021; 7(10):343.
3. Prakash, P., Kumar, M., Pundir, A., Puri, S., Prakash, S., Kumari, N., ... & Abdel-Daim, M. M. Documentation of Commonly Used Ethnoveterinary Medicines from Wild Plants of the High Mountains in Shimla District, Himachal Pradesh, India. Horticulturae, 2021; 7(10):351.
4. Srivastava, S. C., Sharma, U. C., Singh, B. K., & Yadava, H. S. (2012). A profile of garlic production in India: facts, trends and opportunities. International Journal of Agriculture, Environment and Biotechnology, 2012; 5(4):477-482.
5. Shi, q.w.; li, l.g.; huo, c.h.; zhang, m.l.; wang, y.f. study on natural medicinal chemistry and new drug development. Chin. Tradit. Herb. Drugs 2010; 41:1583–1589.
6. Fabricant, D. S., & Farnsworth, N. R. The value of plants used in traditional medicine for drug discovery. Environmental health perspectives, 2001; 109(suppl 1):69-75.
7. Gao, x.m.; zhang, t.m.; zhang, j.r.; guo, j.s.; zhong, g.s.chinesemateria medica; china press of traditional chinese medicine: beijing, china, 2007.
8. Alves, R., & Rosa, I. M. Biodiversity, traditional medicine and public health: where do they meet?. Journal of ethnobiology and ethnomedicine, 2007; 3(1):1-9.
9. Kumar, M., Devi, H., Prakash, S., Rathore, S., Thakur, M., Puri, S., & Mekhemar, M. Ethnomedicinal plants used in the health care system: Survey of the mid hills of solan district, Himachal Pradesh, India. Plants, 2021; 10(9):1842.
10. Prakash, P., Kumar, M., Kumari, N., Prakash, S., Rathour, S., Thakur, M., & Mekhemar, M.Therapeutic uses of wild plants by rural inhabitants of Maraog region in district Shimla, Himachal pradesh, India. Horticulturae, 2021; 7(10):343.
11. Prakash, P., Kumar, M., Pundir, A., Puri, S., Prakash, S., Kumari, N., ... & Abdel-Daim, M. M. (2021). Documentation of Commonly Used Ethnoveterinary Medicines from Wild Plants of the High Mountains in Shimla District, Himachal Pradesh, India. Horticulturae, 2021; 7(10):351.
12. Srivastava, S. C., Sharma, U. C., Singh, B. K., & Yadava, H. S. A profile of garlic production in India: facts, trends and opportunities. International Journal of Agriculture, Environment and Biotechnology, 2012; 5(4):477-482.
13. Sasi, M., Kumar, S., Kumar, M., Thapa, S., Prajapati, U., Tak, Y., & Mekhemar, M. Garlic (Allium sativum L.) Bioactives and Its Role in Alleviating Oral Pathologies. Antioxidants, 2021; 10(11):1847.
14. Lawson, L. D. (1998). Garlic: a review of its medicinal effects and indicated active compounds. Blood, 179, 62.
15. Amagase, H., Petesch, B. L., Matsuura, H., Kasuga, S., &Itakura, Y. (2001). Intake of garlic and its bioactive components. The Journal of nutrition, 2001; 131(3):955S-962S.
16. Ventola, C. L. The antibiotic resistance crisis: part 1: causes and threats. Pharmacy and therapeutics, 2015; 40(4):277.
17. Yunus, F. T., &Suwondo, A. (2021, February). Phytochemical Compound of Garlic (Allium sativum) as an Antibacterial to Staphylococcus aureus Growth. In IOP Conference Series: Materials Science and Engineering (Vol. 1053, No. 1, p. 012041). IOP Publishing.
18. Milanda, T. I. A. N. A., Kusuma, A. S. W., & Shanmuganathan, K. U. G. A. N. E. S. H. Antibacterial activity of malacca fruit (Phyllanthus emblica L.) ethanolic extract and fraction againts Bacillus cereus FNCC0057 and Shigella dysentriae ATCC13313. Asian Journal of Pharmaceutical Clinical Research, 2017; 8-10.
19. Saeed, S., & Tariq, P. Antibacterial activities of Emblica officinalis and Coriandrum sativum against Gram negative urinary pathogens. Pakistan journal of pharmaceutical sciences, 2007; 20(1):32-35.
20. Anila, L., & Vijayalakshmi, N. R. Antioxidant action of flavonoids from Mangifera indica and Emblica officinalis in hypercholesterolemic rats. Food chemistry, 2001; 83(4):569-574.
21. Rege, N. N., Thatte, U. M., &Dahanukar, S. A. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 1999; 13(4):275-291.
22. Krishnaveni, M., &Mirunalini, S. Chemopreventive efficacy of Phyllanthus emblica L.(amla) fruit extract on 7, 12-dimethylbenz (a) anthracene induced oral carcinogenesis–A dose–response study. Environmental toxicology and pharmacology, 2012; 34(3):801-810.
23. Vadde, R., Radhakrishnan, S., Kurundu, H. E. K., Reddivari, L., &Vanamala, J. K. Indian gooseberry (Emblica officinalis Gaertn.) suppresses cell proliferation and induces apoptosis in human colon cancer stem cells independent of p53 status via suppression of c-Myc and cyclin D1. Journal of Functional Foods, 2016; 25: 267-278.
24. Kasabri, V., Flatt, P. R., & Abdel-Wahab, Y. H. A. Emblica officinalis stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro. European Journal of Medicinal Plants, 2014; 4(6):753.
25. Rao, T. P., Okamoto, T., Akita, N., Hayashi, T., Kato-Yasuda, N., & Suzuki, K. Amla (Emblica officinalis Gaertn.) extract inhibits lipopolysaccharide-induced procoagulant and pro-inflammatory factors in cultured vascular endothelial cells. British journal of nutrition, 2013; 110(12):2201-2206.
26. Middha, S. K., Goyal, A. K., Lokesh, P., Yardi, V., Mojamdar, L., Keni, D. S., & Usha, T. (2015). Toxicological evaluation of Emblica officinalis fruit extract and its anti-inflammatory and free radical scavenging properties. Pharmacognosy Magazine, 11(Suppl 3), S427.
27. Mehrotra, S., & Srivastava, A. K. Comparative antimicrobial activities of Neem, Amla, Aloe, Assam Tea and Clove extracts against Vibrio cholerae, Staphylococcus aureus and Pseudomonas aeruginosa. Journal of Medicinal Plants Research, 2010; 4(22):2393-2398.
28. Al-Rehaily, A. J., Al-Howiriny, T. S., Al-Sohaibani, M. O., & Rafatullah, S. (2002). Gastroprotective effects of ‘Amla’Emblica officinalis on in vivo test models in rats. Phytomedicine, 2002; 9(6):515-522.
29. Mehmood, M. H., Rehman, A., Rehman, N. U., & Gilani, A. H. Studies on prokinetic, laxative and spasmodic activities of Phyllanthus emblica in experimental animals. Phytotherapy Research, 2013; 27(7):1054-1060.
30. Fujii, T., Wakaizumi, M., Ikami, T., & Saito, M. Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. Journal of Ethnopharmacology, 2008; 119(1):53-57.
31. Yokozawa, T., Kim, H. Y., Kim, H. J., Okubo, T., Chu, D. C., &Juneja, L. R. Amla (Emblica officinalis Gaertn.) prevents dyslipidaemia and oxidative stress in the ageing process. British Journal of Nutrition, 2007; 97(6):1187-1195.
32. Pathak, P., Prasad, B. G., Murthy, N. A., & Hegde, S. N. The effect of Emblica officinalis diet on lifespan, sexual behavior, and fitness characters in Drosophila melanogaster. Ayu, 2011; 32(2):279.
33. Rawal, S., Singh, P., Gupta, A., & Mohanty, S. (2014). Dietary intake of Curcuma longa and Emblica officinalis increases life span in Drosophila melanogaster. BioMed Research International, 2014.

34. Yokozawa, T., Kim, H. Y., Kim, H. J., Tanaka, T., Sugino, H., Okubo, T., & Juneja, L. R. Amla (Emblica officinalis Gaertn.) attenuates age-related renal dysfunction by oxidative stress. J. of Agricultural and Food Chemistry, 2007; 55(19):7744-7752.
35. Variya, B. C., Bakrania, A. K., & Patel, S. S. Emblica officinalis (Amla): A review for its phytochemistry, ethnomedicinal uses and medicinal potentials with respect to molecular mechanisms. Pharmacological research, 2016; 111:180-200.
36. Sripanidkulchai, B., &Junlatat, J. Bioactivities of alcohol based extracts of Phyllanthus emblica branches: antioxidation, antimelanogenesis and anti-inflammation. Journal of natural medicines, 2014; 68(3):615-622.
37. Bhandari, P. R., &Kamdod, M. A. Emblica officinalis (Amla): A review of potential therapeutic applications. International Journal of Green Pharmacy (Medknow Publications & Media Pvt. Ltd.), 2014; 6(4).
38. Zhu, X., Wang, J., Ou, Y., Han, W., & Li, H. Polyphenol extract of Phyllanthus emblica (PEEP) induces inhibition of cell proliferation and triggers apoptosis in cervical cancer cells. European Journal of Medical Research, 2013; 18(1):1-5.
39. Fujii, T., Wakaizumi, M., Ikami, T., & Saito, M. Amla (Emblica officinalis Gaertn.) extract promotes procollagen production and inhibits matrix metalloproteinase-1 in human skin fibroblasts. Journal of Ethnopharmacology, 2008; 119(1):53-57.
40. Kumar, K. S., Vani, M. G., Wang, S. Y., Liao, J. W., Hsu, L. S., Yang, H. L., &Hseu, Y. C. In vitro and in vivo studies disclosed the depigmenting effects of gallic acid: A novel skin lightening agent for hyperpigmentary skin diseases. Biofactors, 2013; 39(3):259-270.
41. Li, P., Xu, G., Li, S. P., Wang, Y. T., Fan, T. P., Zhao, Q. S., & Zhang, Q. W. Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design. Journal of agricultural and food chemistry, 2008; 56(4):1164-1171.
42. Li, P., Yin, Z. Q., Li, S. L., Huang, X. J., Ye, W. C., & Zhang, Q. W. Simultaneous determination of eight flavonoids and pogostone in Pogostemoncablin by high performance liquid chromatography. Journal of Liquid Chromatography & Related Technologies, 2014; 37(12):1771-1784.
43. Yi, Y., Zhang, Q. W., Li, S. L., Wang, Y., Ye, W. C., Zhao, J., & Wang, Y. T. Simultaneous quantification of major flavonoids in “Bawanghua”, the edible flower of Hylocereusundatus using pressurised liquid extraction and high-performance liquid chromatography. Food chemistry, 2012; 135(2):528-533.
44. Zhou, Y. Q., Zhang, Q. W., Li, S. L., Yin, Z. Q., Zhang, X. Q., & Ye, W. C. Quality evaluation of semen oroxyli through simultaneous quantification of 13 components by high performance liquid chromatography. Current Pharmaceutical Analysis, 2012; 8(2):206-213.
45. Du, G., Zhao, H., Song, Y., Zhang, Q., & Wang, Y. (2011). Rapid simultaneous determination of isoflavones in Radix puerariae using high‐performance liquid chromatography–triple quadrupole mass spectrometry with novel shell‐type column. Journal of separation science, 2011; 34(19):2576-2585.
46. Nair, A., Balasaravanan, T., Jadhav, S., Mohan, V., & Kumar, C. Harnessing the antibacterial activity of Quercus infectoria and Phyllanthus emblica against antibiotic-resistant Salmonella Typhi and Salmonella Enteritidis of poultry origin. Veterinary World, 2020; 13(7), 1388.
47. Gangadhar, M., Shraddha, K., & Ganesh, M. Antimicrobial screening of garlic (Allium sativum) extracts and their effect on glucoamylase activity in-vitro. Journal of Applied Pharmaceutical Science, 2012; 2(1):16.
48. Shakya, V. K., Saxena, R. C., & Shakya, A. (2010). Effect of ethanolic extract of Allium sativum bulbs on Streptozotocin induced diabetic rats. J. Chem. Pharm. Res, 2010; 2(6):171-175.
49. Fauzi, N. I., Ardiansyah, S. A., &Hidayat, S. (2018, December). SkriningMekanismeKerjaDaunMalaka (Phyllanthus emblica L.) SebagaiAntidiabetes. In Talenta Conference Series: Tropical Medicine (TM) 2018; 1(3):106-110).
Statistics
40 Views | 21 Downloads
How to Cite
Raj, M., Vyas, G., Sharma, S., & Bishnoi, H. (2022). THE A Comparative Review on Allium Sativum and Phyllanthus Emblica. Asian Journal of Pharmaceutical Research and Development, 10(2), 77-82. https://doi.org/https://doi.org/10.22270/ajprd.v10i2.1107