Antibacterial and Antifungal Activities of Patikan Kebo (Euphorbia Hirta L.) Herb Ethanol Extract
DOI:
https://doi.org/10.22270/ajprd.v9i5.1017Keywords:
Ethanol, Extract, Euphorbia hirta L, antibacterial, antifungalAbstract
Objective: The aim of this study was to determine the content of secondary metabolites, and the concentration of extracts that were effective as antibacterial and antifungal agents.
Methods: The research method was carried out experimentally with several stages; making Simplicia, Simplicia characterization, maceration, phytochemical screening, making test solutions, and testing antibacterial and antifungal activities.
Results: The results of phytochemical screening of the ethanol extract of the patikan kebo herb (Euphorbia hirta L.) showed the existance of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. Furthermore, the results of the antibacterial and antifungal activity test showed that the ethanol extract of the patikan kebo herb showed the diameter of the inhibition zone in the Strong category as the concentration increased.
Conclusion: The herbal extract of patikan kebo (Euphorbia hirta L.) has antibacterial and antifungal activity so that it has potential as a natural antibiotic.
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References
2. Kumar GS. Antimicrobial Effects of Indian Medicinal Plants Against Acne-inducing Bacteria. Tropical Journal of Pharmaceutical Research 2007; 6(2):717–723.
3. Rajeh M. A. Basma., Zakaria Z., Sreenivasan S., Lachimanan Y. L., and Santhanam A. Assessment of Euphorbia hirta L. Leaf, Flower, Stem, and Root Extracts For Their Antibacterial and Antifungal Activity and Brine Shrimp Letahality. Molecules 2010; 15:6008 – 6018.
4. El-Mahmood MA. Antibacterial Activity of Crude Extracts of Euphorbia hirta Against Some Bacteria Associated with Enteric Infections. Journal of Medicinal Plants Research 2009; 3(7):498–505.
5. Gayathri A and K. Vijaya Ramesh. Antifungal activity of Euphorbia hirta L. inflorescence extract against Aspergillus flavus-A mode of action study. International Journal of Current Microbiology and Applied Science 2013; 2(4):31-37
6. Davis, W.W and T.R Stout. Disc Plate methods of microbiological antibiotic assay. J. Microbiology 1971; 4:659-665.
7. Ahmad W., Shilpa Si., and Sanjay K. Phytochemical Screening and Antimicrobial Study of Euphorbia hirta Extracts. Journal of Medicinal Plants Studies 2017; 5(7):183–186.
8. Rajasudha V and R. Manikandan. Phytochemical Screening and High–Performance Liquid Chromatography (HPLC) Profile of Different Extracts of Euphorbia hirta (Linn). Journal of Pharmacognosy and Phytochemistry 2019; 8(1):45 – 50.
9. Hazra K., Sreya D., Shreya G., Deboleena P., and Mruthyumjaya MR. Phytopharmacognostic Evaluation of Plant Euphorbia hirta L. International Journal of Herbal Medicine 2019;7(3):7–15.
10. Al-Snafi A.E. Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)-A review. IOSR Journal of Pharmacy 2017; 7(3):07-20.
11. Xie., Yixi., Yang., Weijie., Tang., Fen., Chen., Xiaoqing., Ren and Licheng. Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism 2015; 22(1):132-149.
12. Magozwi D.K., Mmabatho D., Nthabiseng M., Xavier S. N., Rui W.M.K., Molahlehi S., Lyndy J.M., Wilma A. A. and Jacqueline T. Flavonoids from the Genus Euphorbia: Isolation, Structure, Pharmacological Activities and Structure-Activity Relationships. Pharmaceuticals 2021; 14. 428: 1-34.
13. Simanjuntak, H.A. Antibacterial Activity of Ethanolic Extract of Kitolod (Hippobroma longiflora) Leaf Against Staphylococcus aureus and Salmonella typhi. Asian Journal of Pharmaceutical Research and Development 2020; 8(1):52-54.
14. Simanjuntak, H.A and Kasta G. The Effect of Infusion Breadfruit Leaves (Artocarpus altilis (Parkinson) Fosberg) on Blood Glucose Levels in Male Mice (Mus musmuculus) Diabetes Mellitus Type 2. Asian Journal of Pharmaceutical Research and Development 2021; 8(6):01-04.
15. Kemboi D., Xaloni P., Moses L., and Jacqueline T. A Review of The Ethnomedicinal Uses, Biological Activities, and Triterpenoids of Euphorbia Species. Molecules 2020; 25(19):1-29.
16. Shih M.F and Jong Y.C. Potential Applications of Euphorbia hirta in Pharmacology. Drug Discovery in Pharmacognosy 2012; 165-180.
17. Huang L., Shilin C., and Meihua Y. Euphorbia hirta (Feiyangcao): A review on its ethnopharmacology, phytochemistry and pharmacology. Journal of Medicinal Plants Research 2012; 6(39):5176-5185.
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