Indole-3-Glyoxylamide- An Important Scaffold for Anticancer Activity

  • C. Buvana Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.
  • Avinash Raveendran Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.
  • R. Suresh Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Chidambaram, Tamilnadu, India
  • Y. Haribabu Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.

Abstract

Synthetic indolylglyoxyl amides were identified as a new group of microtubule destabilizing anticancer agents, with the most active derivative N-(pyridine-4-yl)-[1-(4-chlorobenzyl)indol-3-yl]glyoxylamide (Indibulin, D-24851, ) possessing the promising in vitro activity against SKOV3 ovarian cancer, U87 glioblastoma and ASPC-1 pancreatic cancer cells. Indole-3-glyoxylamides are an attractive lead series for continuing development as potential therapeutic agents. A number of Indole-3-glyoxylamides have previously been reported as tubulin polymerization inhibitors; exert a cytotoxic effect against multiple cancer cell lines. Recently, substituted indolylglyoxylamides were found to exhibit anticancer, antiprion and anti HIV activity. This developed an interest in reviewing lead based on indole-3-glyoxylamide. This review focused on overview of drug molecule of indole-3-glyoxylamide. We hope that the review could give a guide to develop newer anti-cancer agents with greater potency against drug-sensitive and drug-resistant cancers in the future.


 

Keywords: Indole-3-glyoxylamide, Anticancer activity, Indibulin (D-24851)

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Author Biographies

C. Buvana, Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.

Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.

Avinash Raveendran, Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.

Deparment of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.

R. Suresh, Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Chidambaram, Tamilnadu, India

Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Chidambaram, Tamilnadu, India

Y. Haribabu, Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.

Department of Pharmaceutical chemistry, Grace College of Pharmacy, Palakkad, Kerala.

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How to Cite
Buvana, C., Raveendran, A., Suresh, R., & Haribabu, Y. (2020). Indole-3-Glyoxylamide- An Important Scaffold for Anticancer Activity. Asian Journal of Pharmaceutical Research and Development, 8(4), 218-230. https://doi.org/https://doi.org/10.22270/ajprd.v8i4.803