Antidiabetic Activity of Lactobacillus fermentum Bacteria from Dengke Naniura Goldfish (Cyprinuscarpio) in Nicotinamide-Streptozotosin Induced Rats

  • Syahputri H Department of Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Silalahi J Department of Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Harahap U Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.
  • Satria D Departement of Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Abstract

Objectives: This study aims to determine the effect of Lactobacillus fermentum on decreasing blood glucose levels, sRAGE, HbA1c levels.Methods: Testing was done on male rats, which consisted of 7 groups. Group 1 as negative control was given Na-CMC0.5%, group 2 was given Lactobacillus fermentum isolate dose 0.5mL, group 3 was given Lactobacillus fermentum isolate dose 1mL, group 4 was given Lactobacillus fermentum isolate dose 1.5mL, group 5 was given Lactobacillus fermentum isolate dose 2 mL, group 6 as positive control was given glibenclamide dose 0.45 mg/kg, and group 7 as the normal group. Decreased KGD, sRAGE, HbA1C.Results: The results of statistical analysis showed that the administration of Lactobacillus fermentum showed the effect of a decrease in blood glucose (KGD) rats that were not significantly different than the positive control group (p <0.05). From the results of testing the Lactobacillus fermentum 2 mL treatment group gave the best results on decreasing sRAGE levels; decreased HbA1C.Conclusion: Based on the results of this study Lactobacillus fermentum bacteria can reduce blood glucose, sRAGE, HbA1C levels in rats induced by Nicotinamide-Streptozotosin.


 

Keywords: sRAGE, HbA1C, Insulin, Lactobacillus fermentum, reduction of KGD.

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Author Biographies

Syahputri H, Department of Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Silalahi J, Department of Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Chemistry, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Harahap U, Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Department of Pharmacology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Satria D, Departement of Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

Departement of Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia.

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How to Cite
H, S., J, S., U, H., & D, S. (2020). Antidiabetic Activity of Lactobacillus fermentum Bacteria from Dengke Naniura Goldfish (Cyprinuscarpio) in Nicotinamide-Streptozotosin Induced Rats. Asian Journal of Pharmaceutical Research and Development, 8(4), 12-15. https://doi.org/https://doi.org/10.22270/ajprd.v8i4.778