Simultaneous Estimation of Admixture drugs by RP-HPLC: A Review

  • Shipra Saini Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India
  • Sulekha Mandal Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India
  • Dilip Agarwal Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Abstract

Recently, high demand of high-throughput analyses with high sensitivity and selectivity to molecules and drugs in different classes with different physical-chemical properties and a reduction in analysis time—is a principal milestone for novel methodologies that researchers are trying to achieve especially when analytical procedures are applied to clinical purposes. In addition, to avoid high doses of a single drug that could cause serious side effects, multi-drug therapies are often used to treat numerous diseases. For these reasons, the demand for methods that allow the rapid analysis of mixed compounds has increased in recent years. In order to respond to these needs, new methods and instruments have been developed. However, often the complexity of a matrix can require a long time for the preparation and processing of the samples. Different problems in terms of components, types of matrices, compounds and physical-chemical complexity are encountered when considering drugs association profiles for quantitative analyses. This review addresses not only recently optimized procedures such as chromatographic separation, but also methods that have allowed us to obtain accuracy (precision and trueness), sensitivity and selectivity in quantitative analyses for cases of drug associations.


 


 

Keywords: Analytical methods; chromatographic procedures; drug associations; hyphenated techniques; biologic matrices.

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Author Biographies

Shipra Saini, Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Sulekha Mandal, Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Dilip Agarwal, Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, India

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How to Cite
Saini, S., Mandal, S., & Agarwal, D. (2020). Simultaneous Estimation of Admixture drugs by RP-HPLC: A Review. Asian Journal of Pharmaceutical Research and Development, 8(4), 180-185. https://doi.org/https://doi.org/10.22270/ajprd.v8i4.699