Nanosized and Enhancement of Solubility Fisetin

  • Muhammad Dzakwan Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia
  • Eko Pramukantoro Ganet Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia
  • Mauludin Rachmat Department of Pharmaceutics, School of Pharmacy,Institute Technology Bandung, Indonesia
  • Saleh Wikarsa 4Department of Pharmaceutics, School of Pharmacy,Institute Technology Bandung Labtek VII Ganesha10 Bandung, Indonesia

Abstract

Fisetin (3,3,4,7-tetrahydroxyflavone) is a natural antioxidant that has shown to posses anticancer, antioxidant and anti-inflammatory properties. However, the poor solubility leads to poor bioavailability and limits its development.The aim of the research is to investigate the effect of fisetin nanosuspension using a nanoprecipitation technique and additional stabilizers polysorbat 80, SLS, PVA and Eudragit on particle size average, polydispersity index and zeta potential.The suspensions of microcrystalline FIS were prepared by a nanoprecipitation technique with different proportion of stabilizers fixed. The nanosuspension produced was then characterized using Photon Correlation Spectroscopy (PCS) in  term of particle size distribution, polydispersity index, zeta potential and morphology nanosuspensiom (TEM). Result showed fisetin nanosuspension were successfully prepared by anti-solvent precipitation with additional stabilizer SLS and polysorbat 80. The nanosuspension containing polysorbat 80 showed smaller average particle size of 225.7 nm ± 1.31, a polydispersity index of 0.272 ±0.02 and zeta potential -39.3 ± 0.26 was obtained. Conclusion, FIS nanosuspension successfully prepared by nanoprecipitation tecnique with the polysorbate 80 as stabilizer and ethanol as solvent were spherical in shape..

Keywords: Fisetin,nanosuspension,nanoprecipitation,polysorbate 80, ethanol

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Author Biographies

Muhammad Dzakwan, Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Eko Pramukantoro Ganet, Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Faculty of Pharmacy, University Setia Budi, Surakarta, Central Java, Indonesia

Mauludin Rachmat, Department of Pharmaceutics, School of Pharmacy,Institute Technology Bandung, Indonesia

Department of Pharmaceutics, School of Pharmacy,Institute Technology Bandung, Indonesia

Saleh Wikarsa, 4Department of Pharmaceutics, School of Pharmacy,Institute Technology Bandung Labtek VII Ganesha10 Bandung, Indonesia

4Department of Pharmaceutics, School of Pharmacy,Institute Technology Bandung

Labtek VII Ganesha10 Bandung , Indonesia

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How to Cite
Dzakwan, M., Ganet, E., Rachmat, M., & Wikarsa, S. (2019). Nanosized and Enhancement of Solubility Fisetin. Asian Journal of Pharmaceutical Research and Development, 7(2), 6-10. https://doi.org/https://doi.org/10.22270/ajprd.v7i2.465