https://ajprd.com/index.php/journal/issue/feedAsian Journal of Pharmaceutical Research and Development2024-02-15T10:16:52+0530Prof. (Dr.) M. P. Khinchieditorajprd@gmail.comOpen Journal Systems<div class="aboutushome" align="justify"><strong>Asian Journal of Pharmaceutical Research and Development (AJPRD)</strong> is a new online international journal allowing free unlimited access to abstract and Full text. The journal is devoted to the promotion of pharmaceutical sciences and related disciplines. It seeks particularly (but not exclusively) to encourage pharmaceutical and allied research of tropical relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and health the health care professionals. It will also provide an international plate form for the communication and evaluation of data, methods and findings in pharmaceutical sciences and related disciplines. Although primarily devoted to original research papers, the journal welcomes reviews on current topics of special interest and relevance.</div> <div class="aboutushome"> </div>https://ajprd.com/index.php/journal/article/view/1344Spectrophotometry and Histological Staining Potential of Ethanol Extract of brassica Oleracea (Red Cabbage) on Selected Organs of Sprague Dawley rat2024-01-23T13:51:13+0530Esther E. EyoMfoniso I. UdonkangImeobong J. InyangLeonard O. UmunnakweRaymond Eworo<p><strong>Objective: </strong>Plants with coloring and dyeing effects have widely been used in histological staining. Natural dyes are less expensive, nontoxic, renewable and sustainable resources, with minimal environmental impact compared to synthetic stains. Red cabbage is one of such natural dyes. The red color of the red cabbage derived from anthocyanin pigments confers a great advantage to red cabbage. In this study, the physiochemical and spectrophotometric characteristics of red cabbage as well as its histological staining potentials on various tissues were carried out to determine its tissue specificity.</p> <p><strong>Methods:</strong>The ethanol extract of red cabbage was prepared using 100% ethanol, then pH, spectrophotometry, and concentration of the red cabbage ethanol extract were measured before the solution was divided into two equal volumes, and one part was added with 2ml glacial acetic acid while the other part was added with 10g of aluminum sulfate. The two solutions were used to stain 10% neutral-buffered formalin-fixed, paraffin-wax-embedded tissue sections separately. Stained sections were viewed with a photomicroscope.</p> <p><strong>Results: </strong>The ethanol extract was acidic at a pH of 4.89 and the spectrophotometry graph showed 3 peak absorbances at the wavelengths of 395nm, 545nm and 670nm. The maximum absorbance was 0.795 at the wavelength of 395nm and this is indicative of the pigment cyanidin which is the anthocyanin present in red cabbage. The red cabbage ethanol extract with both glacial acetic acid and aluminum sulfate showed good histological details in tissues of kidney, stomach, lungs, liver, spleen, small intestine and skin. There was no difference between the red cabbage ethanol extract and the conventional hematoxylin and eosin stain (P>0.05). Our study showed that red cabbage ethanol extract with acetic acid and aluminum sulfate is stable at 4<sup>o</sup>C, with color amber to light gold with a pH of 4.89 and a concentration of 1000 which gave good histological details. In general, our result indicates that red cabbage ethanol extract is an efficient stain for histological tissue structures and can be used as an eco-friendly alternative to eosin.</p> <p><strong>Conclusion: </strong>Red cabbage ethanol extract stained basic structures of the cell such as the cytoplasm, muscle fibers and mucins. Therefore, red cabbage ethanol extract can be used in histological staining when appropriate modifications are done.</p> <p> </p> <p> </p> <p><em> </em></p>2024-02-15T00:00:00+0530Copyright (c) 2024 Esther E. Eyo, Mfoniso I. Udonkang, Imeobong J. Inyang, Leonard O. Umunnakwe, Raymond Eworohttps://ajprd.com/index.php/journal/article/view/1347Spectroscopic Study of Synthesized Copper Nanoparticles by Chemical Reduction Method2023-08-02T07:11:21+0530Nandkishor N. PadoleNilesh V. MajgavaliMonali A. MeshramNitin N. Padole<p>Well-dispersed and uniform-size preparation of Copper nanoparticles and its X-ray diffraction studies are reported in this paper. A simple and cheapest chemical reduction method with copper sulfate pentahydrate as a main precursor is used for the synthesis of Copper nanoparticles. A wide range of experimental conditions has been adopted in this process and its X-Ray diffraction characterizations have been studied. UV-visible spectroscopic analysis showed the maximum absorption at 295 nm. Transmission electron microscopy reveals the spherical morphology of the synthesized particles. The results confirm copper nanopowder with an average particle size in the range of 30-60 nm.</p> <p> </p>2024-02-15T00:00:00+0530Copyright (c) 2024 Nandkishor N. Padole, Nilesh V. Majgavali, Monali A. Meshram, Nitin N. Padolehttps://ajprd.com/index.php/journal/article/view/1346Studies in the Measurements of Refractive Index of Substituted Thio-Carbamidonapthols In 100% & 90% Binary Mixtures of 70% Etoh-H2O Mixture at 298.15 K2024-01-23T14:53:45+0530S. R. KhanM. S. Lunge LungeD. T. Tayade<p>After synthesis of any chemical moiety; physico-chemical properties of that chemical moiety must be investigated. These are essential for predications of medicinal, agricultural, industrial, biochemical and biological applications theoretically and refractometric measurement is one of the best method for the determination of the same in the drug chemistry. Refractometric measurements of chemical moiety are one of the important study for understanding the pharmacokinetics study of synthesized or isolated chemical moiety. Considering all these things refractrometic measurements of 4-amino-1-naphthol [4-AN], 4-phenylthiocarbamido-1-naphthol [4-PTCN], 4-<em>p</em>-chlorophenylthiocarbamido-1-naphthol [4-<em>p</em>-CPTCN] and 4-<em>p</em>-tolylthiocarbamido-1-naphthol [4-<em>p</em>-TPTCN] have been carried out at 100% and 90%, binary mixtures of 70% ethanol-water mixtures in 0.002, 0.004, 0.006, 0.008 and 0.01M concentrations at 298.15K were successfully investigated and gave good results.</p> <p><strong> </strong></p>2024-02-15T00:00:00+0530Copyright (c) 2024 S. R. Khan, M. S. Lunge Lunge, D. T. Tayadehttps://ajprd.com/index.php/journal/article/view/1358Antitumor Activity and Synthesis of 1, 2-Disubstituted Benzimidazoles in One-Pot Diverse Using Bismuth (III) Trifluoromethanesulfonate as Catalyst2023-08-20T08:32:02+0530A VenkateswarluM HarikrishnaP. Thriveni<p>Various 1,2-disubstituted benzimidazoles were synthesized in a facile method using Bismuth(III) trifluoromethanesulfonate. It is suggested that formation of an intermediate between the substrate, amine and solvent gives the N-arylation process. This developed protocol is demonstrated by the efficient reactions involving various substituents ranging from electron-withdrawing groups to electron-donating groups.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 A Venkateswarlu, M Harikrishna, P. Thrivenihttps://ajprd.com/index.php/journal/article/view/1352Impact of nutrition intervention on the nutritional status and cognitive function among children (6-12 years) – An Interventional Study from South India2023-08-20T08:00:43+0530Chandan SahDr. Sowjanya BattuDeepak Prasad YadavAjay Kumar DasB. A. Vishwanath<p><strong>Aim:</strong> The aim of this study was to prepare Methotrexate and triherbal loaded topical emulgels for anti-arthritic activity.</p> <p><strong>Methods:</strong> The above sources are subjected to soxhlation and aqueous and hydroalcoholic extracts of the above three will be prepared. The extracts will be prepared by proper maceration in suitable solvents in required proportions. The resultant extract will be converted into emulgel as follows: The gel portion of the emulgel will be made by dissolving carbopol-934 in cold water with constant stirring at a moderate speed until uniform mixture is obtained. The pH was then adjusted to 6–6.5 using triethanolamine (TEA). Tween 80 was dissolved in distilled water to prepare the aqueous phase of the emulsion while for the preparation of the oil phase of the emulsion; span 80 was dissolved in liquid paraffin. To preserve the emulsion, benzalkonium chloride was dissolved in water and the suitable amounts of extracts and methotrexate is dissolved in ethanol then both solutions are mixed with the aqueous phase. Both the aqueous and the oil phase were heated in a water bath at 70 °C separately. Then the oil phase was added drop wise to the aqueous phase with continuous stirring using homogenizer at speed of 3000 rpm for 10 min then cold to room temperature. At the end the gel and emulsion portions were mixed in 1:1 ratio with moderately stirring to prepare emulgel. The preparation is made viscous to be spreadable on the skin sufficiently without friction by trial-and-error way of mixing different proportions of gelling polymers. The formulation thus prepared is subjected to suitable characterization and evaluation studies and the optimized formulation is reported after obtaining results.</p> <p><strong>Results:</strong> Drug-polymer compatibility studies (FT-IR and DSC) showed no incompatibility between the drug and polymer. In- vitro permeation studies though egg membrane showed good drug release in the range of 78.91 to 98.92% over a period of 2 hours. The best formulation was found to be F3 showing in-vitro drug release of 98.92%. The correlation and coefficient (R2) values obtained from the kinetic equation shows the drug release from all the formulation (F1-F9) follow zero order drug release mechanism.</p> <p><strong>Conclusion:</strong> It can be concluded that Methotrexate and Triherbal loaded Topical emulgels could be a better formulation approach for Anti-arthritic activity.</p> <p> </p>2024-02-15T00:00:00+0530Copyright (c) 2024 Chandan Sah, Dr. Sowjanya Battu, Deepak Prasad Yadav, Ajay Kumar Das, B. A. Vishwanathhttps://ajprd.com/index.php/journal/article/view/1345A Singal Case Studyon Coccygodynia2024-01-23T14:47:53+0530Dr. Damini ParmarDr. Harshit ShahDr.Dhruval PadadhariaDr. Dipa KananiDr. Sonal Panchal<p>Pain in the coccyx region is known as coccydynia or coccygodynia. Coccygeal pain has been documented since the 16th century, according to Simpson, coccygeal pain has been recognised for hundreds of years, treating it can be challenging and occasionally contentious due to the complex nature of coccygeal pain. Its genesis is influenced by numerous physiological and psychological factors. With or without conservative treatment, most occurrences of coccydynia recover within weeks to months, but in a small number of people, the pain can last a long time and be incapacitating. Female gender and obesity have been linked to an increased chance of acquiring the condition. The anatomy, physiology, diagnosis and therapy of coccydynia are briefly discussed in this Study. For individuals with intractable coccyx discomfort, a multidisciplinary strategy including physical therapy, ergonomic modifications, drugs, injections, and potentially psychotherapy has the best chance of recovery.</p> <p>A 26 years old Female patient came in OPD with Symptoms of Pain and tenderness in coccyx region, aggravated with sitting position. In past history a patient is fall down from vehicle in direct vertical position, at this incidous mild discomfort in lower back region, after that gradually increase pain in coccyx region within two days. Patient could not able to seat proper and pain remain constant. So, she came to Govt. Akhandanand Hospital for ayurvedic treatment.The patient was treated with ayurvedic medicines Yogaraj Guggulu, Dashmoolkwath, Tab.bocomo and advise to take sitz bath with luke warm water and use wedge shape cushion on sitting position. The patient was advised to follow up initially after 7 days and later after every 15<sup>th</sup>days. After 7 days there were mild pain and no tenderness. After that pain gradually decrease. The pain was completely gone on the third follow up and no any other complaints related to coccydynia.</p> <p> </p>2024-02-15T00:00:00+0530Copyright (c) 2024 Dr. Damini Parmar, Dr. Harshit Shah, Dr.Dhruval Padadharia, Dr. Dipa Kanani, Dr. Sonal Panchalhttps://ajprd.com/index.php/journal/article/view/1348A Comprehensive Review on Solid Lipid Nanoparticles2023-08-02T07:13:26+0530Urkunde A.SubodhAtram C. SandeepSable P. RupaliRajput J. VrundaGawai G. Anuja<p>This review provides a comprehensive analysis of solid lipid nanoparticles (SLNs) as promising drug delivery systems. SLNs have garnered significant attention due to their unique properties, including biocompatibility, controlled drug release, and improved stability. The abstract explores the key aspects of SLN formulation, emphasizing the influence of lipid composition, surfactants, and production methods on particle size, drug loading, and release kinetics. The impact of these parameters on the pharmacokinetics and therapeutic efficacy of SLN-incorporated drugs is discussed. Furthermore, the review delves into the various methods employed for characterizing SLNs, such as dynamic light scattering, transmission electron microscopy, and X-ray diffraction, highlighting their roles in ensuring product quality. The abstract also touches upon recent advancements in SLN research, including surface modification strategies and their implications for targeted drug delivery.In conclusion, this review consolidates current knowledge on SLNs, offering valuable insights into their formulation, characterization, and potential applications in pharmaceutical research. The synthesis of relevant literature provides a foundation for researchers and practitioners to navigate the evolving landscape of SLN-based drug delivery systems.</p> <p><strong> </strong></p>2024-02-15T00:00:00+0530Copyright (c) 2024 Urkunde A.Subodh, Atram C. Sandeep, Sable P. Rupali, Rajput J. Vrunda, Gawai G. Anujahttps://ajprd.com/index.php/journal/article/view/1349An Updated Comprehensive Review on Novel Drug Delivery Systems (NDDS) In the Pharmaceuticals2023-08-02T07:16:28+0530Vinay Kumar Rao KhadamRavindra Pal SinghDeepak PrajapatiMohammad YunusBalkishan PrajapatSantosh Kumar RaiPrakriti KumariDipon Gogoi<p>The field of pharmaceutical sciences has witnessed a paradigm shift with the advent of Novel Drug Delivery Systems (NDDS), which aim to enhance therapeutic efficacy, reduce side effects, and improve patient compliance. This comprehensive review explores the latest advancements and innovations in NDDS, encompassing a diverse range of delivery platforms and strategies.(NDDs are transforming the landscape of pharmaceutical treatment, offering unparalleled potential for enhanced therapeutic efficacy, improved bioavailability, controlled release, targeted delivery, and enhanced stability. This comprehensive review explores the diverse landscape of NDDS, highlighting recent advancements and addressing key challenges. Prominent NDDS include liposomes, nanoparticles, micelles, polymeric drug conjugates, monoclonal antibodies, implants, and patches. Each system possesses unique properties and applications, tailored to specific drugs and therapeutic needs. Recent breakthroughs in targeted nanocarriers, gene therapy vectors, and 3D-printed personalized dosage forms are pushing the boundaries of innovation. The main highlights of the present review firstly the basics on NDDs, the several approaches of nano drug carriers for the drug delivery with their preparation methods and example. The middle version of review discuss the recent advancements techniques in the preparation of NDDs carriers and lastly the marketed formulation of particular drug carrier.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 Vinay Kumar Rao Khadam, Ravindra Pal Singh, Deepak Prajapati, Mohammad Yunus, Balkishan Prajapat, Santosh Kumar Rai, Prakriti Kumari, Dipon Gogoihttps://ajprd.com/index.php/journal/article/view/1350A Technical Note: on Microspheres2023-08-02T07:19:09+0530Sable P. RupaliGawai G. AnujaRajput J. VrundaUrkunde A. SubodhDr. Sandeep C Atram<p>Microspheres have become a center of research. Microspheres are an excellent way to deliver drugs to specific sites and control their effects. They are characterized by free-flowing spheres composed of biodegradable or non-biodegradable proteins or synthetic polymers, with an ideal particle size of 1-1000 microns. Microspheres encapsulate active pharmaceutical ingredients (APIs) in a polymer matrix that protects the API from environmental degradation. Pharmacokinetic limitations can be overcome by modifying the formulation to release the drug slowly during prolonged action. The purpose of this review is to list the different types of microspheres, their different preparations, limitations, advantages and disadvantages, characterization, applications, and recent developments in microspheres and various compatibility studies.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 Sable P. Rupali, Gawai G. Anuja, Rajput J. Vrunda, Urkunde A. Subodh, Dr. Sandeep C Atramhttps://ajprd.com/index.php/journal/article/view/1354Self Nanoemulsifying Drug Delivery System: A Comrhensive Review2023-08-20T08:03:07+0530Gawai G. AnujaAtram C. SandipSable P. RupaliRajput J. VrundaUrkunde A. Subhod<p>SNEDDS is also important to create a wide interface for distributing the hydrophobic drug between the oil and aqueous phase, increasing the overall bioavailability of the drug.This process can be stabilized using emulsifiers that reduce interfacial tension.Self-nanoemulsified dosage forms can improve the oral bioavailability of biopharmaceutical class II and IV drugs, The potential mechanism by which SNEDDS increases oral bioavailability.Oral administration of peptides due to proteins is a very difficult task due to poor water quality, poor permeability and tolerance of intestinal environmental stability. Many strategies are being investigated to increase the oral absorption of protein. Recently, evaluated the ability of SNEDDS to improve the oral bioavailability of β-lactamase, a model protein. SNEDDS to the solid state can reduce chemical degradation, but in many cases does not eliminate it. Therefore, it is important to identify microenvironment modification strategies to improve the stability of pH-sensitive drugs.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 Gawai G. Anuja, Atram C. Sandip, Sable P. Rupali, Rajput J. Vrunda, Urkunde A. Subhodhttps://ajprd.com/index.php/journal/article/view/1355Simultaneous Analysis of Anti-Hypertensive Drugs by RP-HPLC: An Overview2023-08-20T08:08:23+0530Akshay KatkaleSagar FodaseAshok PingleGanesh DhikalePratik WaghmareDeepak Dhake<p>High performance liquid chromatography (HPLC) is an important qualitative and quantitative technique, generally used for the estimation of pharmaceutical and biological samples. In now a day pharmaceutical market, many newer antihypertensive combination drugs are available to control hypertension as well as to keep society healthy and stress free. All presently available old drugs have frequent dosing produces various side effects. So, there is need to analyse such antihypertensive drugs. The aim of this review is to analysed such commonly used antihypertensive combination drugs by using reverse phase high performance liquid chromatography (RP-HPLC). Reversed-phase high-performance liquid chromatography (RP-HPLC) involves the separation of molecules on the basis of hydrophobicity. The separation depends on the hydrophobic binding of the solute molecule from the mobile phase to the immobilized hydrophobic ligands attached to the stationary phase. The drugs like Amlodipine besylate and Valsartan, Irbesartan and Hydrochlorothiazide, Atenolol and Chlorthalidone, Hydrochlorothiazide and Candesartan, Ramipril and Amlodipine, Hydrochlorothiazide and Enalapril, Quinapril and Hydrochlorothiazide etc. About fifteen combination drugs are analysed by using RP-HPLC. This review assists in appropriate selection of column, mobile phase, pH, flow rate, detector and form of such combination drugs.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 Akshay Katkale, Sagar Fodase, Ashok Pingle, Ganesh Dhikale, Pratik Waghmare, Deepak Dhakehttps://ajprd.com/index.php/journal/article/view/1356To Study the Regulatory Guidelines for API of Ibuprofen: A Review2023-08-20T08:10:17+0530Shraddha V. JadhavNikam A.S.Gunjal S.B.<p>The registration structure of pharmaceutical outcomes is governed by pharmaceutical medication regulatory affairs. It has a broad scope that encompasses all aspects of documentation and marketing in a legitimate format. In our country, the pharmaceutical business is one of the most coordinated industries. Regulatory affairs experts require a current market overview in order to connect pharmaceutical companies with international regulatory bodies. Regulatory issues RA is a career that overlaps a number of industries, including pharmaceuticals, medical devices, and biotechnology. Within the pharmaceutical sector, RA has a specific connotation. DRA is a dynamic field that encompasses both scientific and legal aspects of drug development. DRA professionals are dedicated individuals who take pride in their contribution to improving humanity<sup>’</sup>s health and quality of life. The scope of RA as a profession is much more than the registration of outcomes. They provide strategic and practical advice to businesses at a high level. Their small continues through preparation, marketing, and post-marketing. Professionals from RA help the organisation avoid problems caused by sloppy records, incorrect scientific reasoning, or poor data presentation. The claims that can be made for the product on labelling or in advertising are usually restricted in most outcomes areas where regulatory limitations are imposed.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 Shraddha V. Jadhav, Nikam A.S., Gunjal S.B.https://ajprd.com/index.php/journal/article/view/1357A Technical Note: On Niosomes2023-08-20T08:12:25+0530Rajput J. VrundaGawai G. AnujaSable P. RupaliUrkunde A. SubodhAtram C. Dr. Sandeep<p>A wide range of substances that serve as carriers can be suspended or captured by the Niosomes Delivery System (MDS), which can then be included into a designed product like a gel cream or powder. The formulation's primary goal is to get the desired medication concentration in the blood. Niosomes are a type of porous medication delivery device for small particles. They are tiny, spherical particles that resemble microscopic and have a broad porous surface. In addition, they may increase stability by altering the drug's release pattern while minimizing negative effects. The serious condition impacting social life is acne vulgaris. Acne can be involved; alternation of follicular keratinization seldom causes significant systemic issues, but maturity, especially for women, which leads to drugs assist to reduce the production of sebum, which is mostly responsible for reducing the formation of acne on the skin. The use of niosomes as carriers for medications that target acne vulgaris is currently receiving more attention in research that focuses on illness detection and a brief to target acne vulgaris. Acne vulgaris is a serious condition that is currently affecting people's social lives. Increased sebum production, bacterial involvement, altered follicular keratinization, and altered follicular barrier are all characteristics of acne. The current review is focused on the niosomes as carriers for the drug targeting the acne vulgaris, brief discussion on the present and future aspects of the niosomes to targetet acne vulgaris.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 Rajput J. Vrunda, Gawai G. Anuja, Sable P. Rupali, Urkunde A. Subodh, Atram C. Dr. Sandeephttps://ajprd.com/index.php/journal/article/view/1338A Descriptive Analysis of Therapeutic Drug Monitoring In India2023-12-09T08:23:43+0530Sarah KhanDr.Tabrez Uz Zaman<p>Therapeutic drug monitoring (TDM) has evolved into therapeutic drug management throughout the past three to four decades, becoming a crucial facet of precision medicine. Even though India has one of the fastest-growing economies in the world, TDM is not widely used there. At the moment, it is restricted to a small number of teaching hospitals and academic medical institutes. Other therapeutic domains, such anticancer, antifungal, antibacterial, and antitubercular medications, have shown considerable promise to enhance patient outcomes in Indian settings, aside from immunosuppressive pharmaceuticals. The population of this subcontinent is unique in terms of the importance of TDM due to factors like the higher prevalence of nutritional deficiencies, tropical diseases, the widespread adoption of alternative medicines, unlike pharmacogenomics, and the scarcity of population-specific data on the therapeutic ranges of multiple drugs.TDM has not gotten the interest it merits in India, despite its vast applicability and influence on clinical science. This study aims to present a SWOT (strength, weakness, opportunity, and threats) analysis of TDM in India so that suitable measures for promoting TDM growth can be envisaged. Forming a collaborative group with all the stakeholders—including TDM experts, physicians, and the government—and coming up with a National Action Plan to support TDM are urgent needs. To determine the country's TDM focus areas, nodal TDM facilities should be formed, and pilot programmes should be launched. Capacity development and awareness rising are also important steps towards integrating TDM into traditional clinical practice.</p> <p> </p>2024-02-15T00:00:00+0530Copyright (c) 2024 Sarah Khan, Dr.Tabrez Uz Zamanhttps://ajprd.com/index.php/journal/article/view/1368India’s Growing Demand of Nutraceuticals2023-09-18T07:23:44+0530Saqlain Ahmad<p>Nutraceuticals are nutritive ingredients—a cross between food and medicine—that are physiologically active and have the power to preserve optimum health and advantages. These goods are essential to maintaining human health and well-being, especially in light of upcoming treatment advancements. Due to their safety profile, medicinal effects, and nutritional advantages, nutraceuticals have gained popularity. Global demand for nutraceuticals is rising in the areas of disease prevention, health care promotion, and other services. In this overview, several drug-nutritional interactions are additionally outlined using a variety of instances. The concluding portion of the assessment states that there are several patents on nutraceuticals for use in agriculture and in treating a variety of disorders, confirming the exponential rise of the market for nutraceuticals. In addition to being used for nutrition, nutraceuticals have been employed as an adjunct treatment for both the prevention and the treatment of a number of disorders, including the reduction of adverse effects from radiation and chemotherapy for cancer. Nutraceutical formulation development presents a number of obstacles that are often solved by a variety of innovative nano-formulation techniques. Any negative effects of nutraceuticals products may be avoided with the aid of prior knowledge about different medication combinations. Moreover, micronized food items along with additional nutraceutical supplements with enhanced health advantages are produced thanks to nanotechnology. The most recent significant results (clinical research) on nutraceuticals that demonstrate the bioactive compounds in these supplements have a therapeutic effect on a range of ailments have also been included in this review article.</p> <p> </p> <p> </p>2024-02-15T00:00:00+0530Copyright (c) 2024 Saqlain Ahmadhttps://ajprd.com/index.php/journal/article/view/1343Polyherbal Chewing Gum: A Comprehensive Exploration of Design and Quality for Mouth Ulcers Relief2024-01-21T07:56:08+0530Kanchan .N. DhamaiDr. M. P. JadhaoDr. M.D. GameS. G. JawarkarV. M. Waghulkar<p>Gummies are mobile drug delivery systems. Extract from herbal medicines can be incorporated into chewing gum and can be used in the treatment of mouth ulcers. It was concluded that the gum is an excellent drug delivery system for self-medication as it is convenient and can be administered directly without water and contain one or more active substances that are released by chewing and are intended for use for local treatment of oral diseases or systemic administration after absorption through the buccal mucosa. Natural a gum base that is economical, safe, environmentally friendly and used in the treatment of various oral diseases.</p>2024-02-15T00:00:00+0530Copyright (c) 2024 Kanchan .N. Dhamai, Dr. M. P. Jadhao, Dr. M.D. Game, S. G. Jawarkar, V. M. Waghulkar