TY - JOUR AU - Lucrèce, Kotin Mahoutin AU - Judith, Ahounouaikpe Fifamin AU - Huguette, Akakpo Baï AU - Fidèle, Assogba Mahoudo AU - Pierre, Dansou Houndjovi AU - Djimon, Gbenou Joachim PY - 2021/04/15 Y2 - 2024/03/28 TI - Vigna Comosa Baker Aerial Part’s Extracts Effects on Hyperglycemia and Hepatic Glucose’sliberation JF - Asian Journal of Pharmaceutical Research and Development JA - Asian J Pharm Res Dev VL - 9 IS - 2 SE - Research Articles DO - 10.22270/ajprd.v9i2.965 UR - https://ajprd.com/index.php/journal/article/view/965 SP - 11-17 AB - <p><em>Vignacomosa&nbsp;</em>Baker (<em>V. Comosa)</em> is a plant used by Beninese Oueme department’s populationfor the treatment of diabetes without any scientific study showing its effectiveness. The objective of this study is to investigate the effects of theextracts of <em>V. Comosa</em>on hyperglycemic rabbits by Oral Glucose Tolerance Test (OGTT) and on hepatic glucose liberation. Phytochemical screening revealed that the plant contains alkaloids, tannins, flavonoids, mucilage, triterpenoids, steroids, reducing compounds, saponins, oses and holosides.Cytotoxity test showed that those extracts were free of toxicity. The extracts showed anti-hyperglycemic activities doses and time depending. The effective doses are 500 mg/kg for the aqueous extract and 1000 mg/kg for the ethanolic extract. The extracts are effective as compared with glibenclamide (reference product). Moreover, the <em>ex vivo</em> test conducted on the liver revealed that <em>V. Comosa</em> aqueous extract inhibits the hepatic glucose liberation and 500 mg/mL is the most effective dose. The results of this study account for the plant under consideration of its traditional usage in the treatment of diabetes.</p><p>&nbsp;</p> ER -