TY - JOUR AU - S, Wulansari AU - J, Reveny AU - M, Nainggolan PY - 2020/12/15 Y2 - 2024/03/28 TI - Formulation of Black Cumin (Nigella Sativa L.) Ethanol Extract Gel Preparation with Addition of Dimeticone as Hair Tonic JF - Asian Journal of Pharmaceutical Research and Development JA - Asian J Pharm Res Dev VL - 8 IS - 6 SE - Research Articles DO - 10.22270/ajprd.v8i6.875 UR - https://ajprd.com/index.php/journal/article/view/875 SP - 42-45 AB - <p><strong>Objective</strong>: This study aims to formulate a gel preparation for the ethanol extract of Black Cumin (<em>Nigella sativa</em> L.) with the addition of dimethicone as a hair tonic.</p><p><strong>Methods</strong>: Characterization examinations of Black Cumin (<em>Nigella sativa</em> L.) simplicia were carried out. Simplicia is macerated using 80% ethanol and concentrated in a rotary evaporator then in a freeze dryer until the extract is thick. The concentrations taken are 3%, 5% and 7%. Then tested the simplicia characterization, rat hair growth activity and an evaluation of the preparations was carried out, namely the homogeneity, organoleptic test, and microbial contamination test.</p><p><strong>Results</strong>: The results of the simplicia characterization test were water content of 6.63%, water soluble content of 24.64%, total ash content of 3.55% and acid insoluble ash content of 0.29%. Hair tonic preparations are stable in storage for up to 12 weeks from organoleptic, homogeneity. The hair growth activity of the ethanol extract hair tonic gel from 3 concentrations, the best was 7% (1.96 ± 0.00).</p><p><strong>Conclusion</strong>: Black Cumin (<em>Nigella sativa</em> L.) ethanol extract gel has hair growth activity.</p><p>&nbsp;</p> ER -