TY - JOUR AU - M, Julianty S. AU - A, Arianto AU - Y, Yuandani PY - 2020/10/15 Y2 - 2024/03/28 TI - Determination of Sun Protection Factor of Blemish Balm Nanocream Containing Avobenzone, Octyl Methoxycinnamate, and Vitamin C JF - Asian Journal of Pharmaceutical Research and Development JA - Asian J Pharm Res Dev VL - 8 IS - 5 SE - Research Articles DO - 10.22270/ajprd.v8i5.841 UR - https://ajprd.com/index.php/journal/article/view/841 SP - 9-13 AB - <p><strong>Objective:</strong> The aim of this study was to determine sun protection factor of blemish balm nanocream (BB nanocream) containing avobenzone, octyl methoxycinnamate and vitamin C.</p><p><strong>Method:</strong> The formulation of blemish balm nanocreams using a combination of a variety of concentrations of vitamin C (5, 7.5, and 9%), 3% avobenzone, and 7.5% octyl methoxycinnamate. The safety of the BB nanocream containing the highest concentration of vitamin C was examined using skin and eye irritation tests on the rabbit. SPF value of BB nanocreams determined by using UV-Vis Spectrophotometry method and compared with BB cream.</p><p><strong>Results:</strong> All BB nanocream containing vitamin C, avobenzone, and octyl methoxycinnamate did not irritate the eyes and skin of rabbits. The SPF value of BB nanocream containing a combination of 3% avobenzone, 7.5% octyl methoxycinnamate and vitamin C of 5, 7 and 9% were 18.0497, 21,0857, and 21.5883 respectively. The SPF value of BB nanocream without avobenzone, octyl methoxycinnamate and vitamin C was 10.4798 and bb krim was 15,8515.</p><p><strong>Conclusions:</strong> All BB nanocream formula containing 3% avobenzone, 7.5% octyl methoxycinnamate and Vitamin C (5%, 7%, and 9%) were not irritating the eyes and rabbit skin. The BB nanocream containing 3% avobenzone, 7.5% octyl <strong>methoxycinnamate and 9% vitamin C has the highest SPF value</strong><strong>. </strong></p><p>&nbsp;</p> ER -