@article{Fauziah_Kardela_Tinsia_2022, title={¬Antidiabetic Activity of Ethanol Extract of Tetracera scandens (L.) Merr. Stems}, volume={10}, url={https://ajprd.com/index.php/journal/article/view/1176}, DOI={10.22270/ajprd.v10i5.1176}, abstractNote={<p>Diabetes mellitus is a metabolic disorder which had a  high prevalence in Indonesia. Traditional medicinal plants have been developed to treat diabetes mellitus. One of them is <em>Tetracera scandens </em>(L.) Merr.This study aimed to determine the antidiabetic activity of the ethanol extract of <em>T.scandens </em>stems on blood glucose levels, insulin levels, and homeostatic model assessment for insulin resistance (HOMA-IR) in mice induced by alloxan. Animals were grouped into five groups: normal group, negative control, and extract doses of 175, 350, and 700 mg/kg BW. Animals were induced with an alloxandose of 175 mg/kg BW. The extract was given orally for 21 days.The results showed that the administration of ethanol extract of<em>T.scandens </em>stemscould significantly reduce blood glucose levels, increase insulin levels and reduce insulin resistance (p<0.05).It can be concluded that the ethanol extract of <em>T.scandens </em>potential to develop as herbal medicine in diabetes mellitus therapy. Further study is needed toconfirmthe antidiabetic activity of<em> T.scandens.</em></p> <p> </p>}, number={5}, journal={Asian Journal of Pharmaceutical Research and Development}, author={Fauziah, Fitra and Kardela, Widya and Tinsia, Dwi Julda}, year={2022}, month={Oct.}, pages={23–27} }