Spectrophotometric Evaluation of Antiepileptic Activity of Ficusracemosa in Chemicals Induced Epilepsy in Mice
DOI:
https://doi.org/10.22270/ajprd.v9i5.997Keywords:
Pentelynetetrazole, Anticonvulsant activity, diazepam, Ficus racemosabark.Abstract
Objective: To Evaluvate of Antiepileptic Acivity of Ficus Racemosa Extract Against Chemicals Induced epilepsy in mice, ficusracemosa is also used as antihyperglycemic, antiinflammatery , hepatoprotective action. Method : Anticonvulsant activity of three distinct dose levels of ethanolic extract of Ficus racemosa (100, 200, and 400 mg/kg) was tested in Swiss albino mice in seizures induced by Pentylenetetrazol (PTZ). Statistical analysis was carried out by one-way analysis of variance followed by Dunnett's test. Results: The presence of , flavonoids, were detected in the bark of Ficus racemosa. The extract dose-dependent effect in the delay of the onset of seizures and reduction in the duration of seizure.Conclusion : The ethanolic extract of Ficus racemosa exhibited significant and dose-dependent antiepileptic activity, which may be due to the presence of antioxidant principles like flavanoidsand other phytoconstituent produce protective activity againstPTZ.
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