Spectrophotometric Evaluation of Antiepileptic Activity of Ficusracemosa in Chemicals Induced Epilepsy in Mice

  • Prajakta J. Chavan Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.
  • Atish B. Velhal. Vithal J Chawre Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.
  • Vivek K. Redasani Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.

Abstract

Objective: To Evaluvate of Antiepileptic Acivity of Ficus Racemosa Extract Against Chemicals Induced epilepsy in mice, ficusracemosa is also used as antihyperglycemic, antiinflammatery , hepatoprotective action. Method : Anticonvulsant activity of three distinct dose levels of ethanolic extract of Ficus racemosa (100, 200, and 400 mg/kg) was tested in Swiss albino mice in seizures induced by Pentylenetetrazol (PTZ). Statistical analysis was carried out by one-way analysis of variance followed by Dunnett's test. Results: The presence of , flavonoids, were detected in the bark of Ficus racemosa. The extract dose-dependent effect in the delay of the onset of seizures and reduction in the duration of seizure.Conclusion : The ethanolic extract of Ficus racemosa exhibited significant and dose-dependent antiepileptic activity, which may be due to the presence of antioxidant principles like flavanoidsand other phytoconstituent produce protective activity againstPTZ.


 


 

Keywords: Pentelynetetrazole, Anticonvulsant activity, diazepam, Ficus racemosabark.

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Author Biographies

Prajakta J. Chavan, Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.

Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.

Atish B. Velhal. Vithal J Chawre, Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.

Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.

Vivek K. Redasani, Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.

Department of Pharmacology ,YSPM’s Yashoda Technical Campus Wadhe ,Satara , India.

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How to Cite
Chavan, P., Vithal J Chawre, A. B., & Redasani, V. ( ). Spectrophotometric Evaluation of Antiepileptic Activity of Ficusracemosa in Chemicals Induced Epilepsy in Mice. Asian Journal of Pharmaceutical Research and Development, 9(5), 62-66. https://doi.org/https://doi.org/10.22270/ajprd.v9i5.997