A Review on Medicinal Plants of Natural Origin for Treatment of Polycystic Ovarian Syndrome (PCOS)

  • Shivani Andhalkar Department of Pharmacology, YSPM’s Yashoda Technical Campus Wadhe, Satara, India.
  • Vitthal Chaware Head of Department (Pharmacology), YSPM’s Yashoda Technical Campus, Wadhe, Satara, India.
  • Vivek Redasani Principal, YSPM’s Yashoda Technical Campus, Wadhe, Satara, India.

Abstract

Polycystic ovarian syndrome (PCOS) related infertility is a global problem that is spreading at an alarming rate. Chronic anovulation, polycystic ovaries, and hyperandrogenism, as well as abnormal menstrual cycles, hirsutism, acne, and infertility, are all symptoms of this condition. PCOS is linked to insulin resistance and elevated levels of male hormones (androgens). Among other things, an inactive lifestyle, a lack of exercise, dietary changes, and stress are all contributing factors. Curcuma longa, Aloe barbadensis, Mentha piperita, Allium fistulosum Cinnamonum zeylanicum, and other plants have been shown to be effective in the treatment of PCOS. The aim of this review is to summarise the most effective medicinal plants that are used in the treatment or prevention of PCOS. Special emphasis is placed on the role of insulin resistance and the possible utility of insulin sensitizers in the treatment of PCOS.


 

Keywords: Polycystic ovarian syndrome (PCOS), Screening methods of pcos, Pathophysiology of pcos.

Downloads

Download data is not yet available.

Author Biographies

Shivani Andhalkar, Department of Pharmacology, YSPM’s Yashoda Technical Campus Wadhe, Satara, India.

Department of Pharmacology, YSPM’s Yashoda Technical Campus Wadhe, Satara, India.

Vitthal Chaware, Head of Department (Pharmacology), YSPM’s Yashoda Technical Campus, Wadhe, Satara, India.

Head of Department (Pharmacology), YSPM’s Yashoda Technical Campus, Wadhe, Satara, India.

Vivek Redasani, Principal, YSPM’s Yashoda Technical Campus, Wadhe, Satara, India.

Principal, YSPM’s Yashoda Technical Campus, Wadhe, Satara, India.

References

1. Trivax and Azziz. Diagnosis of Polycystic Ovary Syndrome. Clin Obstet Gynaecol. 2007; 50(1):168-177.
2. Patel, S. J Ster Biochem and Mol Biology (PCOS), an inflammatory, systemic lifestyle endocrinopathy. 2018(April),0-1.
3. Goodarzi M., A.R. Diagnosis, epidemiology and genetics of the polycystic ovary syndrome.Best Pract and Res Clin Endocrin and Met. 2006; 20(2):193-205.
4. Agarwal A, Gupta S, Sharma R.K. Role of oxidative stress in female reproduction. 2005; 21:1–21.
5. Richard S. Legro, Silva A. Arslanian. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab.2013
6. Begum GS, Shariff A, Ayman G, Mohammad B, Housam R, Khaled N. Assessment of Risk Factors for development of Polycystic Ovarian Syndrome. Int J Contemp Med Res. 2017; 4(1):2454–7379.
7. Balen A. The pathophysiology of polycystic ovary syndrome: Trying to understand PCOS and its endocrinology. Best Pract Res Clin Obstet Gynaecol. 2004; 18(5 SPEC. ISS.): 685–706.
8. Dumesic, D. A., Oberfield, S. E. Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. Endocrine Reviews, 2015; 36(5):487–525.
9. Shi D, Vine DF. Animal models of polycystic ovary syndrome: A focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk. Fertil Steril. 2012;98(1):185-193.
10. Osuka, S., Nakanishi, N. Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides. Reprod Med Biol. 2019; 18:151–160.
11. Reddy PS, Begum N, Mutha S, Bakshi V. Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome. Asian Pacific J Reprod. 2016;5(2):116–22.
12. Kafali, H., Iriadam, M. Letrozole-induced polycystic ovaries in the rat: A new model for cystic ovarian disease. Archives of Medical Research. 2004; 35(2):103–108.
13. Maharjan R, Nagar P, Nampoothiri L. Effect of Aloe barbadensis Mill. Formulation on Letrozole induced polycystic ovarian syndrome rat model. J Ayurveda Integr Med. 2010; 1(4):273–9.
14. Yang H, Kim HJ, Pyun B-J, Lee HW. Licorice ethanol extract improves symptoms of polycytic ovary syndrome in Letrozole-induced female rats. Integr Med Res. 2018; 7(3):264–70.
15. Abou-El-Naga, M., Habbak, Z. Potential effects of Mentha piperita (peppermint) on Letrozole-induced polycystic ovarian syndrome in female albino rat. International Journal of Advanced Research. 2015; 3(10), 211–226.
16. Lee, Y. H., Yang, H. Welsh onion root (Allium fistulosum) restores ovarian functions from letrozole induced-polycystic ovary syndrome. Nutrients, 2018; 10(10).
17. Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iran J Basic Med Sci. 2018; 21(6):645–50.
18. Choi, J. H. Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its anti-inflammatory and antioxidant activities. Journal of Ginseng Research, 2020; 44(6):790–798.
19. Saiyed A, Jahan N, Makbul SAA, Ansari M, Bano H, Habib SH. Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res. 2016; 5(4):293–300.
20. Sudhakar, P., Suganeswari, M. Regulation of Estrous cycle using Combination of Gymnema sylvestre and Pergularia daemia in Estradiol Valerate induced PCOS rats. Asian J. Res. Pharm. Sci. 2018; 8(1):04-08.
21. Hossein KJ, Leila K, Ebrahim TK, Nazanin SJ, Farzad P, Elham R, et al. The effect of pomegranate juice extract on hormonal changes of female Wistar rats caused by polycystic ovarian syndrome. Biomed Pharmacol J. 2015; 8(2):971–7.
22. Review P. Anti-androgenic effect of Symplocos racemosa Roxb. against letrozole induced polycystic ovary using rat model. J Coast Life Med. 2013;1(4):309–14.
23. Wang JG, Anderson RA, Graham GM, Chu MC, Sauer MV., Guarnaccia MM, et al. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 2007; 88(1):240-3.
24. Kakadia N, Patel, Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome. J of Trad and Comp Med. 2019; 9(4):336–345.
Statistics
137 Views | 117 Downloads
How to Cite
Andhalkar, S., Chaware, V., & Redasani, V. (2021). A Review on Medicinal Plants of Natural Origin for Treatment of Polycystic Ovarian Syndrome (PCOS). Asian Journal of Pharmaceutical Research and Development, 9(3), 76-81. https://doi.org/https://doi.org/10.22270/ajprd.v9i3.949