A Review on Medicinal Plants of Natural Origin for Treatment of Polycystic Ovarian Syndrome (PCOS)
Polycystic ovarian syndrome (PCOS) related infertility is a global problem that is spreading at an alarming rate. Chronic anovulation, polycystic ovaries, and hyperandrogenism, as well as abnormal menstrual cycles, hirsutism, acne, and infertility, are all symptoms of this condition. PCOS is linked to insulin resistance and elevated levels of male hormones (androgens). Among other things, an inactive lifestyle, a lack of exercise, dietary changes, and stress are all contributing factors. Curcuma longa, Aloe barbadensis, Mentha piperita, Allium fistulosum Cinnamonum zeylanicum, and other plants have been shown to be effective in the treatment of PCOS. The aim of this review is to summarise the most effective medicinal plants that are used in the treatment or prevention of PCOS. Special emphasis is placed on the role of insulin resistance and the possible utility of insulin sensitizers in the treatment of PCOS.
2. Patel, S. J Ster Biochem and Mol Biology (PCOS), an inflammatory, systemic lifestyle endocrinopathy. 2018(April),0-1.
3. Goodarzi M., A.R. Diagnosis, epidemiology and genetics of the polycystic ovary syndrome.Best Pract and Res Clin Endocrin and Met. 2006; 20(2):193-205.
4. Agarwal A, Gupta S, Sharma R.K. Role of oxidative stress in female reproduction. 2005; 21:1–21.
5. Richard S. Legro, Silva A. Arslanian. Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab.2013
6. Begum GS, Shariff A, Ayman G, Mohammad B, Housam R, Khaled N. Assessment of Risk Factors for development of Polycystic Ovarian Syndrome. Int J Contemp Med Res. 2017; 4(1):2454–7379.
7. Balen A. The pathophysiology of polycystic ovary syndrome: Trying to understand PCOS and its endocrinology. Best Pract Res Clin Obstet Gynaecol. 2004; 18(5 SPEC. ISS.): 685–706.
8. Dumesic, D. A., Oberfield, S. E. Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome. Endocrine Reviews, 2015; 36(5):487–525.
9. Shi D, Vine DF. Animal models of polycystic ovary syndrome: A focused review of rodent models in relationship to clinical phenotypes and cardiometabolic risk. Fertil Steril. 2012;98(1):185-193.
10. Osuka, S., Nakanishi, N. Animal models of polycystic ovary syndrome: A review of hormone-induced rodent models focused on hypothalamus-pituitary-ovary axis and neuropeptides. Reprod Med Biol. 2019; 18:151–160.
11. Reddy PS, Begum N, Mutha S, Bakshi V. Beneficial effect of Curcumin in Letrozole induced polycystic ovary syndrome. Asian Pacific J Reprod. 2016;5(2):116–22.
12. Kafali, H., Iriadam, M. Letrozole-induced polycystic ovaries in the rat: A new model for cystic ovarian disease. Archives of Medical Research. 2004; 35(2):103–108.
13. Maharjan R, Nagar P, Nampoothiri L. Effect of Aloe barbadensis Mill. Formulation on Letrozole induced polycystic ovarian syndrome rat model. J Ayurveda Integr Med. 2010; 1(4):273–9.
14. Yang H, Kim HJ, Pyun B-J, Lee HW. Licorice ethanol extract improves symptoms of polycytic ovary syndrome in Letrozole-induced female rats. Integr Med Res. 2018; 7(3):264–70.
15. Abou-El-Naga, M., Habbak, Z. Potential effects of Mentha piperita (peppermint) on Letrozole-induced polycystic ovarian syndrome in female albino rat. International Journal of Advanced Research. 2015; 3(10), 211–226.
16. Lee, Y. H., Yang, H. Welsh onion root (Allium fistulosum) restores ovarian functions from letrozole induced-polycystic ovary syndrome. Nutrients, 2018; 10(10).
17. Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iran J Basic Med Sci. 2018; 21(6):645–50.
18. Choi, J. H. Korean Red Ginseng alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via its anti-inflammatory and antioxidant activities. Journal of Ginseng Research, 2020; 44(6):790–798.
19. Saiyed A, Jahan N, Makbul SAA, Ansari M, Bano H, Habib SH. Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res. 2016; 5(4):293–300.
20. Sudhakar, P., Suganeswari, M. Regulation of Estrous cycle using Combination of Gymnema sylvestre and Pergularia daemia in Estradiol Valerate induced PCOS rats. Asian J. Res. Pharm. Sci. 2018; 8(1):04-08.
21. Hossein KJ, Leila K, Ebrahim TK, Nazanin SJ, Farzad P, Elham R, et al. The effect of pomegranate juice extract on hormonal changes of female Wistar rats caused by polycystic ovarian syndrome. Biomed Pharmacol J. 2015; 8(2):971–7.
22. Review P. Anti-androgenic effect of Symplocos racemosa Roxb. against letrozole induced polycystic ovary using rat model. J Coast Life Med. 2013;1(4):309–14.
23. Wang JG, Anderson RA, Graham GM, Chu MC, Sauer MV., Guarnaccia MM, et al. The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study. Fertil Steril. 2007; 88(1):240-3.
24. Kakadia N, Patel, Effect of Vitex negundo L. seeds in letrozole induced polycystic ovarian syndrome. J of Trad and Comp Med. 2019; 9(4):336–345.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).