Preparation and Characterization of Different Types of Extruders and Its Techniques

Authors

  • Nikita Ogale Junior Research & Development Executive, Umang Pharmatech Pvt. Ltd. Thane, Maharashtra 401 208. India.
  • Komal Kamble Hod Research & Development Department, Umang Pharmatech Pvt. Ltd. Thane, Maharashtra 401 208. India.

DOI:

https://doi.org/10.22270/ajprd.v9i3.929

Keywords:

Excipient, Enzyme, silica, Extruder Techniques,Extrusion, Rapid mixer granulator, Quality Parameters, Physical Characterization

Abstract

The study on characterization of different types of extruder such as single screw cone type, axial type extruder, radial type extruder, die roller type extruder from excipient, enzyme and silica has been performed. The primary goal of the project focuses on making pellets from MCC+LACTOSE, MCC+STARCH, Enzyme and Silica. The process is extremely encouraged in several pharmaceutical industries. The below article will help us understand various aspects of techniques used in the extrusion of pellets. The extruder process of pellets are mainly mixing and extrusion. We will also discuss about the several factors that might influence the pellet quality which includes formulation - granulating liquid, excipients; Equipment (Rapid mixer granulator, various type of extruder, and size of extrusion screen) and process (Extrusion speed, extrusion time). The characterization of the pellets includes estimation of various parameters such as  moisture content ,appearance, shape , bulk density, disintegration of the pellets are explained.

 

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Author Biographies

Nikita Ogale, Junior Research & Development Executive, Umang Pharmatech Pvt. Ltd. Thane, Maharashtra 401 208. India.

Junior Research & Development Executive, Umang Pharmatech Pvt. Ltd. Thane, Maharashtra 401 208. India.

Komal Kamble, Hod Research & Development Department, Umang Pharmatech Pvt. Ltd. Thane, Maharashtra 401 208. India.

Hod Research & Development Department, Umang Pharmatech Pvt. Ltd. Thane, Maharashtra 401 208. India.

References

1. Kumar V, Banker GS. Target oriented drug delivery systems. In; Modern Pharmaceutics. Banker GS, Rhodes CT. Eds. 4th edition, Marcel Dekker, New York, 2005: pp. 529-586.
2. Khar RK, Vyas SP, Ahmad FJ, Jain GK. Lachman/Lieberman’s The Theory and Practice of Industrial Pharmacy, 4th edn. CBS publishers & distributers 2013; pp. 888
3. Vyas SP. Khar RK. Targetted and controlled drug delivery novel carrier systems. Ist edn. CBS publishers and distributers 2002,
4. Kataria S. Middha A. Sandhu P. Bilandi A. Kapoor B. Microsphere: a review, IJRPC 2011; 1(4):1184-1198.
5. Venkatesan K, Manavalan R, Valliapan K. Microencapsulation: a vital technique in novel drug delivery system. J Pharm Sci Res. 2009; 1(4):26-35.
6. Jain NK, Controlled and Novel drug delivery, 04: 236- 237
7. Vyas SP, Khar RK, Targeted and Controlled drug delivery, 07: 418.
8. Ghulam M, Mahmood A, Naveed A, Fatima R.Comparative study of various microencapsulation techniques. Effect of polymer viscosity on microcapsule characteristics, Pak.J.Sci. 2009; 22 (3):291-300
9. Mathew T, Devi S, Prasanth V, Vinod B. Suitability of factorial design in determining the processing factors affecting entrapment efficiency of albumin microspheres. J Pharm Res. 2010; 3(5):1172- 1177
10. Mathew T, Devi S, Prasanth V, Vinod B. NSAIDs as microspheres. The Internet Journal of Pharmacology. 2008; 6(1)
11. Karmakar U, Faysal M. Diclofenac as microspheres. The Internet Journal of Third World Medicine. 2009; 8(1)
12. Jamil. S. Kohli. K. Khar. R.K. Talegaonkar. S. Sustained release sodium alginate microspheres formulation of aceclofenac and paracetamol as potential combination therapy in arthritis. J Pharm Pharmacol.2007; 59(1):117.
13. Aslani P, Kennedy RA. Effect of gelation conditions and dissolution media on the release of paracetamol from alginate gel beads, J Microencapsul1996; 13(5):601- 14.
14. Semalty M. Verma D. Semalty A. Development and evaluation of microcapsules of verapamil hydrochloride Indian Drugs 2011; 48 (08):34-38.
15. Soni ML. Kumar M. Namdeo KP. Sodium alginate microspheres for extending drug
1. release: formulation and in vitro evaluation. Int J Drug deliv 2010; 2:64-68.
16. Mukhopadhyay D. Reid M. Saville D. Tucker IG. Cross-linking of dried paracetamol alginate granules Part 1. The effect of the cross-linking process variables. Int J Pharm. 2005; 299(1- 2):134-45.
17. Deasy PB. Microencapsulation and related drug processes. Marcel Dekker Inc., New York, 1984. Pp9-10.
18. Varde NK, Pack DW. Microspheres for controlled release drug delivery. Expert 2004; 4(1):35-51.
19. Dhakar RC, Maurya SD, Sagar PS, Bhagat S, Prajapati SK, Jain CP. Variables influencing the drug entrapment efficiency of microspheres: A pharmaceutical Review. Der Pharmacia Lett. 2010; 2(5):102-116
20. Dash S. Murthy P.N. Nath L. Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta poloniae pharmaceutical drug research. 2010; 67(3):217-223.

Published

2021-06-15

How to Cite

Ogale, N., & Kamble, K. (2021). Preparation and Characterization of Different Types of Extruders and Its Techniques. Asian Journal of Pharmaceutical Research and Development, 9(3), 48–51. https://doi.org/10.22270/ajprd.v9i3.929

Issue

Vol. 9 No. 3 (2021): Vol 9 No 3 (2021): Vol 9 No 3 (202): Volume 9 Issue 3 May - June. 2021

Section

Research Articles

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