Formulation and Characterization Transdermal Patches of Meloxicam
Objective: Meloxicam is a non-steroidal anti-inflammatory drug (NSAID), an enolic acid derivative that inhibits the cyclooxygenase-2 (COX-2) enzyme.and is usually used by the oral route in the treatment of a wide variety of rheumatic diseases, including rheumatoid arthritis (RA), osteoarthritis, low back pain and various other joint diseases. However, when given, meloxicam is given orally, causing gastrointestinal side effects such as bleeding, gastric ulcers, nausea and vomiting, which can occur at any time when given orally.
Methods: Transdermal patches of meloxicam were made with a mixture of hydroxypropyl methylcellulose and polyvinylpyrrolidone with various concentrations of enhancers (propylene glycol), that were (F1 10%), (F2 20%), and (F3 30%). Transdermal patches of meloxicam are prepared using the solvent evaporation method. The making of transdermal patches meloxicam was evaluated for various parameters, was evaluated physchochemical, organoleptic, thickness, weight uniformity, folding resistance, moisture content, and swelling properties.
Results: Transdermal patches of meloxicam from three formulas were yellow patches, odorless, slightly wet and flat surface, thickness between 0.0225±0.0005 to 0.0249±0.0001 cm, weight uniformity between 322.56±2.22 to 368.98±1.42 mg, folding resistance between 355.00±3.00 to 386.33±1.53, moisture content between 2.889±0.003 to 3.654±0.009% and swelling between 2.86 up to 3.24%.
Conclusion: The results of the study concluded that the meloxicam transdermal patch preparation had good characteristics, the results obtained met the requirements of a transdermal patch, namely having a flat and slightly wet shape and surface, having uniform weight, thickness, folding resistance and having good patch development power.
2. Lakhani P., Bahl R., dan Bafna P. Transdermal Patches: Physiochemical and In-Vitro Evaluation Methods.
3. International Journal of Pharmaceutical Science and Research. (2015); 6 (5):36-1826.
4. Munoz M.D., Castan H., Ruiz M.A., and Morales M.E. Design, development and characterization of transdermal patch of methadone. Journal of Drug Delivery Science and Technology. (2017); 132-145.
5. Shabbir, M., Fazli, A. R., Ali, S., Raza, M., Sharif, A., Akhtar, M. F., at al. Effect of Hydrophilic and Hydrophobic Polymer on In Vitro Dissolution and Permeation of Bisoprolol Fumarate. Acta Poloniae Pharmaceutica. (2017);74(1), 187-197.
6. Sharma M. Transdermal and Intravenous Nano Drug Delivery Systems: Present and Future. Applications of Targeted Nano Drugs and Delivery Systems. (2019);499 – 550.
7. Shet, N.S.and Mistry, R.B. Formulation and evaluation of transdermal patches and to study permeation enhancement effect of eugenol. Journal of Applied Pharmaceutical Science. (2011);1(03):96-101
8. Shivaraj, A., Selvam, R. P., Mani, T. T., dan Sivakumar, T. Design And Evaluation of Transdermal Drug Delivery of Ketotifen Fumarate. Int J Pharm Biomed Research. (2010); (2):42-47.
9. Rajabalaya R., Khanam J., and Nanda A. Design of a matrix patch formulation for long-acting permeation of diclofenac potassium. Asian Journal of Pharmaceutical Sciences. (2008); 3(1):30-39.
10. Rowe, R.C., Sheskey, P.J., dan Quinn, M.E. Handbook of PharmaceuticalExipients. Edisi keenam. London: Pharmaceutical Press and AmericanPharmacists Assosiation. (2009). Halaman: 257, 273, and 413.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).