Ameliorative Effects of Indigenous Medicinal Plants against Hepatic Diseases in Southern Region of India- A Review
Purpose: Liver is an important part in human beings and plays a major role in metabolism and excretion of xenobiotics from the body.
Selection of Data: Further, hepatotoxicity is caused by different types of toxic chemicals, such as antibiotics, and chemotherapeutic agents like paracetamol (C8H9NO2), thioacetamide (C2H5NS), carbon tetrachloride (CCl4), silymarin (C25H22O10), ethanol (C2H5OH), and excessive alcohol in taking and microbes are well researched. The markedly available synthetic drugs to treat liver sickness in this condition also cause further damage to the liver. Hence herbal medicines have being become popularize and their utilized is wide-spread. In plant derived drugs have been utilized in the treatment of liver diseases for a long time and to protect a healthy liver. Liver injury induced by toxins is more common now-a-days. Herbal remedies are focused in the pharmaceutical industry to evolve a safe route for liver disorders and which is very low prize and also no side effects compared with synthetic drugs.
Conclusion: Hence an attempt has been made to reviewed and compiled the available data on photochemical from medicinal plants that have tested in hepatoprotective models using modern scientific system. For the present investigation the selected plants are Avicennia alba, Anisochilus carnosus Baliospermum montanum, Centella asiatica, Clitoria ternatea, Eclipta alba, Justicia adhatada, Phyllanthus emblica, Pisonia Grandis and Syzgium cumini .
2. Sanghvi MM, Hotez PJ, Fenwick A. Neglected tropical diseases as a cause of chronic liver disease: the case of Schistosomiasis and Hepatitis C Co-infections in Egypt. J Int Assoc Stud Live 2013; 33:165-8.
3. Saibal Das S, Sanji Bandyopadhyay, Anand Ramasamy, Somnath Mondal. Evaluation of hepatoprotective activity of aqueous extracts of leaves of Basella alba in albino rats. Natural Product Research: Nat Prod Lett 2014; DOI: 10.1080/ 14786419.2014.971795.
4. Michael PH, Cynthia J. Mechanism of drug induced liver injury. AAPS J 2006; 8:48- 52.
5. Domitrovic R, Potocnjak I. A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives. Arch Toxicol 2015; https://www.researchgate.net/publication/282044038.
6. Aktay G, Deliorman D, Ergun E, Ergun F, Yesilada E, Cevik C. Hepatoprotective effects of Turkish folk remedies on experimental liver injury. J Ethnopharmacol 2000; 73:121-9.
7. Dhiman Chawla D. Herbal Medicines for Liver Diseases Digestive. Dig Dis Sci 2005; 50:1807.
8. Muriel P, Rivera-Espinoza Y. Beneficial drugs for liver diseases. J Appl Toxicol 2008; 28:93-103.
9. Al-Attar AM, Al-Rethea HA. Chemoprotective effect of omega-3 fatty acids on thioacetamide-induced hepatic fibrosis in male rats. Saudi J Biol Sci 2017;24:956– 965.
10. Girish C, Koner BC, Jayanthi S, Ramachandra Rao K, Rajesh B, Pradhan SC. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol 2009;23:735- 45.
11. Ganesan K, Sukalingam K, Xu B. Solanum trilobatum L. ameliorate thioacetamide- induced oxidative stress and hepatic damage in albino rats. Antioxidant 2017;6:68.
12. Zahra AA, Mehmet B, Mohammed AA, Hapipah MA, Hamid AH, Mahmood AA. (2012). Protective Role of Phyllanthus niruri Extract against Thioacetamide-Induced Liver Cirrhosis in Rat Model. Evidence-Base Complem Altern Med 2012;241583: 1/9. doi:10.1155/2012/241583.
13. Kumeshini S, Kumar G, Baojun X. (2018). Protective Effect of Aqueous Extract from the Leaves of Justicia tranquebariesis against Thioacetamide- Induced Oxidative Stress and Hepatic Fibrosis in Rats. Antioxidant 2018; 7:1-10.
14. Vasanth PR, Raghu HC, Vijayan P, Dhanaraj SA, Mallikarjuna CR, Venkata JR, Nitesh K. In vitro and in vivo hepatoprotective effects of the total alkaloid fraction of Hygrophila auriculata leaves. Indian J Pharmacol 2010; 42:99-104.
15. Ai G, Liu Q, Hua W, Huang Z, Wang D. Hepatoprotective evaluation ofthe total flavonoids extracted from flowers of Abelmoschus manihot (L.) Medic: in vitro and in vivo studies. J Ethnophar-macol 2013; 146:794-802.
16. Shailajan S, Joshi M, Tiwari B. Hepatoprotective activity of Parmelia perlata (Huds.) Ach. against CCl4induced liver tox-icity in Albino Wistar rats. J Appl Pharm Sci 2014; 4:70-74.
17. Zhou G, Chen Y, Liu S, Yao X, & Wang Y. In vitro and in vivo hepato-protective and antioxidant activity of ethanolic extractfrom Meconopsis integrifolia (Maxim.) Franch. J Ethnophar-macol 2013; 148:664-670.
18. Robin S, Sunil K, Rana AC. Different models of hepato-toxicity abs related liver diseases: a review. Int Res J Pharm 2012;3:86-95.
19. Saraswat B, Visen PKS, Dayal R, Agarwal DP, Patnaik GK. Protective action of ursolic acid against chemical induced hepatotoxicity in rats. Ind J Pharmacol 1996; 28:232-39.
20. Huang B, Ban X, He J, Tong J, Tian J, Wang, Y. Hepatoprotective and antioxidant activity of ethanolic extracts of edible lotus (Nelumbo nucifera Gaertn.) leaves. Food Chem 2010; 120: 873-878.
21. McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H. The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Investig 2012; 122:1574-1583.
22. Al-Bader A, Omu AE, Dashti H. Chronic cadmium toxicity to sperm of heavy cigarette smokers: immunomodulation by zinc. Arch Androl 1999; 43(2):135-40.
23. Yeh CN, Maitra A, Lee KF, Jan YY, Chen MF. Thioaceatamide-induced intestinal- type Cholangio carcinoma in rat: an animal model recapitulating the multistage progression of human cholangiocarcinoma. Carcinogen 2004; 25(4):631–636, 2004.
24. Kaur V, Kumar M, Kaur P, Kaur S, Singh AP, Kaur S. Hepatoprotective activity of Butea monosperma bark against thioacetamide-induced liver injury in rats. Biomed. Pharmacother 2017:89; 332–341.
25. Bashandy SA, Alaamer A, Moussa SA, Omara E. Role of zinc oxide nanoparticles in alleviating hepatic fibrosis and nephrotoxicity induced by thioacetamide in rats. Can J Physiol Pharmacol 2017; 16;1-8.
26. Feng YM, Wang X, Wang L, Ma XW, Wu H, Bu HR, Xie XY, Qi JN, Zhu Q. Efficacy and safety of combination therapy of chemoembolization and radio frequency ablation with different time intervals for hepatocellular carcinoma patients. Surg Oncol 2017; 26:236–241.
27. Sunderman FW, Sunderman FW. Association of clinical scientists. laboratory diagnosis of liver diseases. St. Louis 1968; 542.
28. Njouendou AJ, Nkeng-Efouet AP, Assob Nguedia JC, Chouna JR, Veerapur V, Thippeswamy BS, Badami S, Wanji S. Protective effect of Autranella congolensis and Sapium ellipticum stem bark extracts against hepatotoxicity induced by thioacetamide. Pharmacol 2014; 2:38-47.
29. Rehman J, Akhtar N, Asif HM, Sultana S, Ahmad M. Hepatoprotective evaluation of aqueous-ethanolic extract of Capparis decidua (Stems) in paracetamol-induced hepatotoxicity in experimental rabbits. Pak J Pharm Sci 2017; 30:507–511.
30. Ahmad F, Tabassum N. Experimental models used for the study of antihepatotoxic agents. J Acute Dis 2012; 1:85-89.
31. Pushpangadan P. Role of Traditional Medicine in Primary Health Care. In: Iyengar PK, Damodaran VK, Pushpangadan P, Editors. Science for Health. Published By State Committee On Science, Technology And Environment, Govt. Of Kerala, 1995.
32. Hari Kumar C, Ramesh A, Suresh Kumar JN, Mohammed Ishaq B. A Review on hepatoprotective activity of medicinal plants. Int J Pharmaceu Scie Res 2011; 2:501- 515.
33. Radha KD, Yogesh KC. Herbal medicines for liver diseases. Diges Dis Sci 2005; 50:1807–1812.
34. Ball KR, Kowdley KV. A review of Silybum marianum (milk thistle) as a treatment for alcoholic liver disease. J Clin Gastroenterol 2005; 39(6):520-528.
35. Jayaraj R, Deb U, Bhaskar AS, Prasad GB, Rao PV. Hepatoprotective efficacy of certain flavonoids against microcystin induced toxicity in mice. Environ Toxicol 2007; 22:472-479.
36. Burkill IH. Ministry of Agriculture and Co-Operatives, Kuala Lumpur, Malaysia 1966; 274-279.
37. Kar DR, Farhad MS, Sahu PK. A review on pharmacological profiles of ethno- medicinal plant: Avicennia alba Blume. Int J Pharm Tech Res 2015; 7:370-373.
38. Bandaranayake WM. Survey of mangrove plants from Northern Australia for phytochemical constituents and uvabsorbing compounds. Curr Topic Phytochem 1995; 14:69-78.
39. Chihiro I, Shinya K, Yuichi K, Hugh TW and Hiroshi F. Chemical Constituents of Avicennia alba. Isolation and structural elucidation of new naphthoquinones and their analogues. Chem Pharmaceu Bullet 2000; 48:339-343.
40. Kamble S, More T, Patil S, Pawar S, Bindurani R, Bodhankar S. Plants used by the tribes of Northwest Maharashtra for the treatment of gastrointestinal disorders. Indian J Trad Knowl 2008; 7:321-325.
41. Subramanian S, Nair A. Flavonoids of the leaves of Mentha spicata and Anisochilus carnosus. Phytochem 1972; 11:452-453.
42. Senatore F, Francesca L, Venza F, Bruno M, Napolitano F. Composition and antibacterial activity of the essential oil of Anisochilus carnosus- a Tamil plant acclimatized in Sicily. Flav Frag J 2003; 18:202-204.
43. Grover J, Adiga G, Vata V, Rathi S. Extracts of Anisochilus carnosus prevent development of experimental inflammation. J Ethanopharm 2001; 7:159-164.
44. Mohammed A, Kumar R, Santosh HY, Nagashruthi M. Antiulcer activity of Anisochilus carnosus leaf extracts in pylorus ligation rats. Indian Drug 2008; 45:979- 983.
45. Malathi R, Kaviyarasan D, Chandrasekar S. Preliminary Phytochemical Analysis of Justicia adhatoda leaves Extract Using Different Solvents. Int J Pharmaceu Drug Anal 2018; 6: 186 – 190.
46. Muthuraman M, Santharam L, Ariraman S, Pemaiah B. Studies on anticancer and antimicrobial efficacy of Anisochilus carnosus extracts. Int J Pharm Pharmaceu Sci 2012; 4:132-135.
47. Shetty V, Lobo R, Kumar N, Lingadakai R, PAI GC, Balaraju G, Balla M. Antimicrobial activity of Anisochilus carnosus (L.F.) Wall against the Human gastric pathogen Helicobacter pylori. Asian J Pharm Clin Res 2017; 10:292-295.
48. Reshi NA, Shankarasingh SM and Hodiyala GV. Evaluation of hepatoprotective potential of leaf and leaf callus extracts of Anisochilus carnosus (L) wall. Int J Phytomed 2018; 10:156-161.
49. Gupta A, Gupta V, Goyal A, Kak A, Pandey C. Standardization of the tetrazolium test in Baliospermum montanum (Willd.) Muell.-Arg. Seed Scie Technol 2010; 38:513- 516.
50. Tripathi YC, Prabhu VV, Pal RS, Mishra RN. Medicinal plants of Rajasthan in Indian system of medicine. Ancien Scie Life 1996; 15:190-212.
51. Singh PB, Aswal BS. Medicinal plants of Himachal Pradesh used in Indian pharmaceutical industry. BMEBR 1992; 13:172-208.
52. Gopakumar K, Yoganarasimhan SN, Nair KV, Murthy KR, Shantha TR, Vijayalakshmi B. Plants used in Ayurveda from Chikmagalur district, Karnataka. J Econ Taxon Bot 1989; 13:367-375.
53. Rout SP, Dash S, & Acharya, R. Danti (Baliospermum montanum Willd.) and its external applications reported in various Ayurvedic pharmacopoeia: An evidence based Review. Int J Res Ayurveda Pharm 2017; 8:52-59.
54. Sushen U and Chouhan A. Chemical Composition of Essential Oil of Centella Asiatica L. By Gc-Ms Analysis. European J Pharmaceu Med Res 2018; 5:544-548.
55. Sivakumar V, Mohamed Sadiq A, Divya Bharathi S. Hepatoprotective activity of Centella asiatica linn. against paracetamol induced liver damage in experimental animals. Emer Life Sci Res 2018; 4(1):19-26.
56. Mukherjee PK, Kumar V, Kumar NS, Heinrich M. The Ayurvedic medicine Clitoria ternatea from traditional use to scientific assessment. J Ethnopharmacol 2008; 120:291-301.
57. Mukherjee PK, Kumar V, Houghton PJ. Screening of Indian medicinal plants for acetyl cholinesterase inhibitory activity. Phytother Res 2007; 21:1142-1145.
58. Thakur AV, Ambwani S, Ambwani TK, Ahmad AH and Rawat DS. Evaluation of phytochemicals in the leaf extract of Clitoria ternatea Willd. through GC-MS analysis. Trop Plant Res 2018; 5:200-206.
59. Nithianantham K, Shyamala M, Chen Y, Latha LY, Jothy SL and Sasidharan S. Hepatoprotective Potential of Clitoria ternatea Leaf Extract Against. Paracetamol Induced Damage in Mice. Molecule 2011; 16:10134-10145.
60. Jadhav VM, Thorat RM, Kadam VJ, Sathe NS. Eclipta alba Linn- ‘‘Kesharaja’’: A Review. J Pharm Res 2009; 2:1236-1241.
61. Mukhopadhyay G, Kundu S, Sarkar A, Sarkar P, Sengupta R, and Kumar C. A review on physicochemical & pharmacological activity of Eclipta alba. Pharma Innovat J 2018; 7(9):78-83.
62. Satheesh Naik K, Gurushanthaiah M, Nagesh Raju G, Johnson WMS, and Mahesh GM. Extraction of Bio-active compounds of Eclipta Alba through GC-MS Analysis. J Pharmaceu Biol Chem Sci 2018; 9:297-302.
63. Tabassum N, Agrawal S, Hepatoprotective activity of Eclipta alba Hassk. Against paracetamol induced hepatocellular damage in mice. JK – Practitioner 2004;11:278- 280.
64. Anjara J, Bhatt G. A glossary of selected indigenous medicinal plant of Inida, Nature Heals, (SRISTI, Ahmedabad) 1995; 11.
65. Chowdhury BK, Bhattacharya AU. A further Quinazoline alkaloid from Adhatoda Vasika, Phytochem 1985; 24:3080-3082.
66. Amin AH, Mehta DR. A bronchodilator alkaloid (vasicinone) from Adhatoda vasica Nees, Nat 1959; 184:1317.
67. Soni S, Anandjiwala S, Patel G & Rajani M. Validation of different methods of preparation of Adhatoda vasica leaf juice by quantification of total alkaloids and vasicine. Indian J Pharm Sci 2008; 70:36.
68. Bhattacharyya D, Pandit S, Jana U, Sur TK. Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on D-galactosamine induced liver damage in rats. Fitoterapia 2005; 76:223-225.
69. Majeed M, Bhat B, Jadhav AN, Srivastava JS, and Nagabhushanam K. Ascorbic acid and tannins from Emblica ofcinalis Gaertn. Fruits—a revisit. J Agricul Food Chem 2009; 57:220-225.
70. Srirama R, Deepak HB, Senthilkumar U, Ravikanth G, Gurumurthy BR, Shivanna MB, Shaanker RU. Hepatoprotective activity of Indian Phyllanthus. Pharmaceu Biol 2012; 50:948-953.
71. Elumalai A, Chinna Eswaraiah M, and Habibur Rahman. Pisonia grandis R.Br – A Medicinal Plant: A Review. Int J Pharma and Biosci 2012; 3:76-80.
72. Sudharameshwari K, Suganya M and Salini R. Studies on Phytochemical and Antimicrobial Activity in Pisonia Grandis R. Br. Int J Pharma Bio Sci 2018; 9(4):213-220.
73. Thenmozhi S, Kameshwaran S, Subasini U, Sathyamurthy D and Dhanalakshmi M. Hepatoprotective Constituents from the Leaves of Pisonia grandis R.Br. Pharmacologia 2013; 4:383-390.
74. Islam M, Hussain K, Latif, Hashmi FK, Saeed H, Bukhari NI, Hassan SS, Danish MZ, Ahmad B. Evaluation of Extracts of Seeds of Syzygium cumini L. for Hepatoprotective Activity Using CCl4-Induced Stressed Rats. Pak Vet J 2015; 35:197- 200.
75. Arunpandiyan J, Roselin RB, Chitra RS and Kaniga P. Review on Syzygium cumini(L.). World J Pharm Pharmaceu Scie 2018; 7:499-507.
76. Ajeet S and Navneet V. Ethnobotanical uses, Antimicrobial potential, Pharmacological properties and Phytochemistry of Syzygium cumini Linn (syn. Eugenia Jambolana (Jamun) – A Review. Int J Innov Pharmaceu Scie Res 2018; 6:32- 47.
77. Borges RM, Bitencourt PE, Stein CS, Bochi GV, Boligon A, Moresco RN, Moretto MB. Leaves and seeds of Syzygium cumini extracts produce significant attenuation of 2, 2 azobis-2-amidinopropane dihydrochloride-induced toxicity via modulation of ectoenzymes and antioxidant activities. J Appl Pharmaceu Scie 2017; 7:037-048.
78. Ward FM, Daly MJ. Hepatic Disease. In: Walker R, Edwards C, editors. Clinical Pharmacy and Therapeutics. Churchill Livingstone New York 1999; 195-212.
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