Characterization and Tablet Property Evaluation of Pregelatinized Starch of Teff (Eragrostis tef )
Starch is a multifunctional pharmaceutical excipient in solid dosage formulations and obtained from different sources. Teff (Eragrostis tef) grain is a source of major staple food in Ethiopia and contains starch. Teff starch was extracted from milled teff flour using 0.075% sodium metabisulphite. The starch was pregelatinized at 60 oC, 70 oC and 80 oC temperatures. When characterized, the pregelatinized teff starches had enhanced physical attributes such swelling capacity, water absorption capacity, granule density, Carr’s index, Hausener’s ratio, flow rate and angle of repose. When incorporated as disintegrant in chloroquine phosphate tablet formulation at 5% and 10% concentrations, tablets containing pregelatinized teff starches showed faster disintegration time and better compressibility compared to the native starch. Tablets containing pregelatinized teff starch at 70 oC and 10% concentration had the fastest disintegration time with 7.55 min. Pregelatinization, a non-expensive type of physical starch modification can be used to enhance excipient attributes of teff starch for its use as disintegrant in tablet formulations.
2. Copeland L, Blazek J, Salman H, Tang MC. Form and functionality of starch. Food Hydrocolloids. 2009; 23(6):1527-34.
3. Central Statistical Agency, The Federal Democratic Republic of Ethiopia. Agricultural Sample Survey 2016/2017: Report on Area and Production of Major Crops (Private Peasant Holdings, Meher Season). 2017; Vol.I, pp: 1-118.
4. Bultosa G, Hall AN, Taylor JRN. Physico-chemical Characterization of Grain Tef [Eragrostis tef (Zucc.) Trotter] Starch. Starch/Stärke. 2002; 54(10):461–8.
5. Zhu F. Chemical composition and food uses of teff (Eragrostis tef). Food Chemistry. 2018; 239:402–15.
6. Gebremariam MM, Zarnkow M, Becker T. Teff (Eragrostis tef) as a raw material for malting, brewing and manufacturing of gluten-free foods and beverages: A review. Journal of Food Science and Technology. 2014; 51(11):2881–95.
7. Chiu C, Solarek D. Modification of starches. In: BeMiller J and Whistler R (eds) Starch: Chemistry and Technology 3rd edn., Academic Press, New York. 2009; pp. 629-55.
8. Nakorn KN, Tongdang T, Sirivongpaisal P. Crystallinity and rheological properties of pregelatinized rice starches differing in amylose content. Starch/Stärke. 2009; 61(2):101-8.
9. Gebremariam T, Schmidt PC. Isolation and physicochemical properties of Enset starch. Starch/Starke. 1996; 48 (6): 208-14.
10. Adedokun MO, Itiola OA. Material properties and compaction characteristics of natural and pregelatinized forms of four starches. Carbohydrate Polymer.2010; 79(4): 818–24.
11. Baks T, Ngene IS, van Soest JJG, Janssen AEM, Boom RM. Comparison of methods to determine the degree of gelatinization for both high and low starch concentrations. Carbohydrate Polymer. 2007; 67(4):481–90.
12. Juliano BO. A simplified assay for milled-rice amylose. Cereal Science Today. 1971; 16: 334–40.
13. Bowen FE, Vadino WA. A Simple Method for Differentiating Starches. Drug Development and Industrial Pharmacy. 1984; 10(3):505–11.
14. Solsulski FW. The Centrifuge Method for Determining Flour Absorptivity in Hard Red Spring Wheats. Cereal Chemistry. 1962; 39:344-50.
15. USP XXII/NF XVII. United states Pharmacopeial Convention, Inc., Rockville, Maryland.
16. Abdallah DB, Charoo NA, Suliman A. Assessment of Pregelatinized Sorghum and Maize Starches as Superior Multi-functional Excipients. Journal of Pharmaceutical Innovation. 2016; 11(2):143-155.
17. Adedokun MO, Itiola OA. Disintegrant activities of natural and pregelatinized trifoliate yams, rice and corn starches in paracetamol tablets. Journal of Applied Pharmaceutical Science. 2011; 01(10):200-6.
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