Revisiting Covid-19: The Novel Disease That Shattered the World

  • Rohit Jain Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India
  • Dilip Agarwal Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India


COVID-19 is a highly contagious disease which is caused by SARS-CoV-2. The disease was initially originated from Wuhan in China. SARS-CoV-2 has a similarity with the SARS-CoV virus and MERS virus. However, the fatality rate in infection caused due to SARS-CoV-2 is less as compared to the infection caused by SARS-CoV and MERS virus. Initially, the WHO had declared the disease as Public Health Emergency of International Concern, and later the disease was categorized as pandemic disease. The disease had affected more than 200 countries. The USA tops the list with the highest number of infected patients. The ACE is the primary receptor of this virus, and the transmission is through both direct and indirect contact. The disease is diagnosed through the reverse-transcription polymerase chain reaction and complimented with a chest computed tomography scan. There is no specific treatment of COVID-19, and supportive management is recommended in severe cases.



Keywords: COVID-19, Transmission, MERS virus, SARS-CoV


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Author Biographies

Rohit Jain, Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

Dilip Agarwal, Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India

Arya college of Pharmacy, Kookas, Jaipur, Rajasthan, India


1. C. Huang, Y. Wang, X. Li, L. Ren, J. Zhao, Y. Hu, et al.Clinical features of patients infected with 2019 novel Corona virus in Wuhan, ChinaLancet, 2020; 395:497-506
2. Chan-Yeung M, Xu RH. SARS: epidemiology. Respirology. 2003; 8:S9–14.
3. Middle East Respiratory Syndrome Corona virus. Available at: Accessed 30 June 2020.
4. Richman DD, Whitley RJ, Hayden FG. Clinical Virology, 4th ed. Washington: ASM Press; 2016.
5. Fehr AR, Perlman S. Corona viruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015; 1282:1-23.
6. C. Burrell, C. Howard, F. MurphyFenner, and White's medical virology (5th ed.), Academic Press, United States (2016).
7. Y. Liu, A.A. Gayle, A. Wilder-Smith, J. Rocklov. The reproductive number of COVID-19 is higher compared to SARS Corona virus J Travel Med,2020; 27(2)
8. Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli R. Features, Evaluation, and Treatment Corona virus (COVID-19). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020.
9. Adhikari SP, Meng S, Wu Y-J, Mao Y-P, Ye R-X, Wang Q-Z, Sun C, Sylvia S, Rozelle S, Raat H, Zhou H. Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of Corona virus disease (COVID-19) during the early outbreak period: a scoping review. Infect Dis Poverty. 2020; 9(1):29.
10. Worldometer. COVID-19 Corona virus Pandemic. Accessed on 01st July 2020.
11. Du Y., Tu L., Zhu P., Mu M., Wang R., Yang P., Wang X., Hu C., Ping R., Hu P., Li T., Cao F., Chang C., Hu Q., Jin Y., Xu G. Clinical features of 85 fatal cases of COVID-19 from Wuhan: a retrospective observational study. Am J Respir Crit Care Med. 2020.
12. Lu R, Zhao X,Li J et al. Genomic characterization and epidemiology of 2019 novelCorona virus: implications for virus origins and receptorbinding. Lancet 2020; 395:565–574.
13. Wölfel, R., Corman, V.M., Guggemos, W. et al. Virological assessment of hospitalized patients with COVID-2019. Nature 2020; 581:465–469.
14. Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol. 2020; 215:108427.
15. E. de Wit, N. van Doremalen, D. Falzarano, et al.SARS and MERS: recent insights into emerging Corona virusesNat. Rev. Microbiol., 2016; 14:523-534.
16. E.J. Snijder, Y. van der Meer, J. Zevenhoven-Dobbe, et al.Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome Corona virusreplication complexJ. Virol., 2006; 80:5927-5940.
17. V.D. Menachery, A. Schafer, K.E. Burnum-Johnson, et al.MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape Proc. Natl. Acad. Sci. U.S.A.,2018; 115.
18. XiaoweiLi X, Geng M, Peng Y et al. Molecular immune pathogenesis and diagnosis of COVID-19. Journal of Pharmaceutical Analysis 2020; 10:102-108
19. Liu Y, Ning Z, Chen Y, Guo M, Liu Y, Gali NK, et al. Aerodynamic characteristics and RNA concentration of SARS-CoV-2 aerosol in Wuhan hospitals during COVID-19 outbreak. bioRxiv. 2020.
20. Van Doremalen N., Bushmaker T., Morris D.H., Holbrook M.G., Gamble A., Williamson B.N. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N. Engl. J. Med. 2020
21. McIntosh K, Hirsch MS, Bloom A. Corona virus disease 2019 (COVID-19). UpToDate Hirsch MS, Bloom A (Eds) Accessed Mar. 2020; 5.
22. Asadi S, et al. Aerosol emission and superemission during human speech increase with voice loudness. Scientific Reports. 2019; 9:2348.
23. Kwan, S. E., Shaughnessy, R., Haverinen-Shaughnessy, U., Kwan, T. A. &Peccia, J. The impact of ventilation rate on the fungal and bacterial ecology of home indoor air. Building and Environment, 106800, doi:10.1016/j.buildenv.2020.106800 (2020).
24. Hospodsky D, et al. Characterizing airborne fungal and bacterial concentrations and emission rates in six occupied children's classrooms. Indoor Air. 2015; 25:641–652. doi: 10.1111/ina.12172.
25. Rothe C, Schunk M, Sothmann P, et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. N Engl J Med. 2020; 382(10):970-971.
26. Yu P, Zhu J, Zhang Z, Han Y. A Familial Cluster of Infection Associated With the 2019 Novel Corona virus Indicating Possible Person-to-Person Transmission During the Incubation Period. J Infect Dis. 2020; 221(11):1757-1761.
27. Bai Y, Yao L, Wei T, et al. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020; 323(14):1406-1407.
28. Macrophage Activation-Like Syndrome: A Distinct Entity Leading to Early Death in Sepsis.Karakike E, Giamarellos-Bourboulis EJFront Immunol. 2019; 10(5):55.
29. Sharma R, Agarwal M, Gupta M, Somendra S, Saxena SK. Clinical Characteristics and Differential Clinical Diagnosis of Novel Corona virus Disease 2019 (COVID-19). Corona virus Disease 2019 (COVID-19). 2020; 55-70. doi:10.1007/978-981-15-4814-7_6
30. Wu Z, McGoogan JM. Characteristics of and Important Lessons from the Corona virus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases from the Chinese Center for Disease Control and Prevention [published online ahead of print, 2020 Feb 24]. JAMA.
31. Su L, Ma X, Yu H, et al. The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19. Emerg Microbes Infect. 2020; 9(1):707-713. doi:10.1080/22221751.2020.1744483
32. Tang YW, Schmitz JE, Persing DH, Stratton CW. Laboratory Diagnosis of COVID-19: Current Issues and Challenges. J Clin Microbiol. 2020; 58(6):e00512-20. Published 2020 May 26. doi:10.1128/JCM.00512-20
33. Bhadra S., Jiang Y.S., Kumar M.R., Johnson R.F., Hensley L.E., Ellington A.D. Real-time sequence-validated loop-mediated isothermal amplification assays for detection of Middle East respiratory syndrome Corona virus (MERS-CoV) PLoS One. 2015;10
34. Chan J.F., Choi G.K., Tsang A.K., Tee K.M., Lam H.Y., Yip C.C. Development and evaluation of novel real-time reverse transcription-PCR Assays with locked nucleic acid probes targeting leader sequences of human-pathogenic Corona viruses. J Clin Microbiol. 2015; 53:2722–2726.
35. Xie X., Zhong Z., Zhao W., Zheng C., Wang F., Liu J. Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing. Radiology. 2020
36. Lu H. Drug treatment options for the 2019-new Corona virus (2019-nCoV) Biosci. Trends. 2020; 14:69–71.
37. Morse J.S., Lalonde T., Xu S., Liu W.R. Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV. Chembiochem. 2020; 21:730–738.
38. Ali I, Alharbi OML. COVID-19: Disease, management, treatment, and social impact. Sci Total Environ. 2020; 728:138861. doi:10.1016/j.scitotenv.2020.138861
39. World Federation of societies of anaesthesiologists - Corona virus. virus [Internet] Accessed on July 1, 2020.
40. Letter regarding the use of continuous positive airway pressure (CPAP) for COVID-19 positive patients | The Faculty of Intensive Care Medicine [Internet].
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How to Cite
Jain, R., & Agarwal, D. (2020). Revisiting Covid-19: The Novel Disease That Shattered the World. Asian Journal of Pharmaceutical Research and Development, 8(4), 213-217.