Formulation, Characterization and In-vitro Evaluation of Cetrizine HCL Oral Disintegrating Tablets

Authors

  • HARITHA PASUPULATI Bharat Institute of Technology, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India
  • Y PHALGUNA Bharat Institute of Technology, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India
  • SANDHYA RUDRA Bharat school of Pharmacy, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India

DOI:

https://doi.org/10.22270/ajprd.v7i5.563

Keywords:

Super disintegrates, Cetrizine hydrochloride, Sodium starch Glycolate, Crosscarmellose.

Abstract

The main objective of this work is to formulate and evaluate Cetirizine HCl MFDT’s using different concentrations of superdisintegrants like croscarmellose sodium (CCS), sodium starch glycolate (SSG) and their combinations in different ratios. The in vitro disintegration time of Cetrizine Hcl prepared by direct compression method by super disintegrates were found to be in the range of 18 to 11sec fulfilling the official requirements. The bulk density and tapped bulk density for the entire formulation blend varied from 0.508 gm/cc to 0.5438 gm/cc and 0.5941 to 0.6408 respectively. The friability was found in all designed formulations in the range 0.42 to 0.74% to be well within the approved range (<1%). The weight variation was found in all designed formulation in the range 97 to 102 mg. The wetting time were found to be in the range of 11 to 18sec. Water absorption ratio for all the formulations found in the range 11 to 16%.combination of sodium starch glycolate and cross carmellose sodium (6% of 25%-ssg&75%ccs)) promotes dissolution rate of drug release when compared to formulation of SSG & CCS alone. It may be due to capillary and wicking mechanism of SSG & CCS.

 

Keywords: 

 

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Author Biographies

HARITHA PASUPULATI, Bharat Institute of Technology, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India

Bharat Institute of Technology, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India

Y PHALGUNA, Bharat Institute of Technology, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India

Bharat Institute of Technology, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India

SANDHYA RUDRA, Bharat school of Pharmacy, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India

Bharat school of Pharmacy, Mangalpally(V), Ibrahimpatnam(M), Ranga Ready, Hyderabad, Telangana, India

 

References

1. Sreenivas SA. Orodispersible tablets: New‐ fangled drug delivery system‐ A Review. IndianJ.Pharm.Educ.Res 2005; 39(4):177‐81.
2. Chein YW. Oral Drug Delivery and Delivery systems, 2nd ed., New York: Marcel Dekker, 1992.
3. Rakesh RK. Orally Disintegrating Tablets novel tablets novel approach to drug delivery. Pharma Review 2004; 2(12):34‐ 36.
4. Kuchekar BS, Badhan AC, Mahajan HS. Mouth dissolving tablets: a novel drug delivery system. Pharma Times 2003; 35:1‐8
5. Brown D. Orally disintegrating tablets-taste over speed. Drug Delivery Technology 2003; 3(6):58-61.
6. Klauke J. Dissolution testing of orally disintegrating tablets. Dissolution Technologies| 2003; (1):6-8.
7. Harmon TM. Beyond the First Generation of Orally Disintegrating Tablets. Emerging Technology. Tablets and Capsules.2006; 9(3).
8. Jashanjit Singh,1 Anil K. Philip,1 and Kamla Pathak Optimization Studies on Design and Evaluation of Orodispersible Pediatric Formulation of Indomethacin AAPS Pharm Sci Tech.2008; 9(1).
9. Gohel M. Tablet Disintegrants. Pharmainfo. 2013.
10. R. F. Shangraw, Vol. 4, 2nd Ed., Marcel Dekker, Newyork USA, p. 85, 1988.
11. M. Jivraj, L. G. Martini and C. M. Thomson, PSTT.2008; 3-58.
12. Gohel MC, Jogani PD, A review of co-processed directly compressible excipients. J Pharm Sci. 2005; 8(1):76-93.
13. Leon Lachman, Herbert Liberman, Joseph L. Kanig, in: Theory and Practice of Industrial Pharmacy, 2nd Edn. Varghese Publication, 1985.
14. Herbert A. Lieberman, Leon lachman and Joseph B. Schwartz; Pharmaceutical Dosage forms; Tablet, Vol. – I 2nd.
15. Raymond C Rowe, Paul J Sheskey and Marian E Quinn; Handbook of Pharmaceutical excipients. 6 edition.
16. Battu SK, Repka MA, Majumdar S, Rao MY. Formulation and evaluation of rapidly disintegrating tablet Fenoverine tablets: Effect of superdisintegrants. Drug Dev Ind Pharm. 2007; 33:1225–32.
17. Gohel M, Patel M, Amin A, Agrawal R, Dave R, Bariya N. Formulation design and optimization of mouth dissolve tablets of nimesulide using vacuum drying technique. AAPS Pharm Sci Tech. 2004; 5:e36.
18. Bi Y, Sunada H, Yonezawa Y, Danjo K, Otsuka A, Iida K. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharmaceut Bull (Tokyo). 1996; 44:2121–7.
19. El-Arini SK, Clas SD. Evaluation of disintegration testing of different fast dissolving tablets using texture analyzer. Pharm Dev Technol, 2002; 7(3):361-371.
20. Klancke J. Dissolution testing of orally disintegrating tablets. Dissolution Technol, 2003; 10(2):6-8.

Published

2019-10-15

How to Cite

PASUPULATI, H., PHALGUNA, Y., & RUDRA, S. (2019). Formulation, Characterization and In-vitro Evaluation of Cetrizine HCL Oral Disintegrating Tablets. Asian Journal of Pharmaceutical Research and Development, 7(5), 19–24. https://doi.org/10.22270/ajprd.v7i5.563

Issue

Vol. 7 No. 5 (2019): Vol 7 No 5 (2019): Volume 7 Issue 5 Sept - Oct. 2019

Section

Research Articles

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