Comparative Study of Natural and Synthetic Superdisintegrants in Orodispersible Metformin Tablet
DOI:
https://doi.org/10.22270/ajprd.v7i3.509Keywords:
Metformin Hcl, Orodispersible tablets, Superdisintegrants, Direct Compression, and Wet granulationAbstract
Objective: The main objective of this study is comparative study of natural and synthetic superdisintegrants in orodispersible Metformin tablet by using direct compression method and wet granulation method.
Method: Orodispersible Metformin tablet were prepared by wet granulation method and direct compression method by using different synthetic and natural superdisintegrants. Orodispersible tablets (ODTs) have received more interest in the pharmaceutical industry for their easy to use and self medication. ODTs overcome the problem of dysphagia (difficulty in swallowing) in the all group age of patients and advantage particularly for the paediatric and geriatric patients. Metformin hydrochloride (Hcl) is an orally administered antihyperglycemic agent, used in the management of non-insulin dependent (type-2) diabetes mellitus. Metformin orodispersible tablet is prepared by using two methods i.e. direct compression method and wet granulation method. Both methods are applied to prepare Orodispersible Metformin tablet. Orodispersible tablet of Metformin was prepared by using superdisintegrants from both natural and synthetic origin. In natural superdisintegrants we used the mucilage of Fenugreek and Lepidium sativum. In synthetic superdisintegrants we used crospovidone and sodium starch glycolate.
Conclusion: In direct compression and wet granulation method final blend and granules were evaluated the flow properties like bulk density, tapped density, compressibility index, hausner’s ratio and angle of repose. The values of precompression parameter evaluated were found to be within the prescribed limit and indicated good flow properties. The data obtained from the post compression methods was studied. Other parameters such as wetting time, water absorption ratio were also evaluated. The formulation (F5) containing 10% crospovidone prepared by wet granulation method was found the optimize formulation.
Keywords: Metformin Hcl, Orodispersible tablets, Superdisintegrants, Direct Compression, and Wet granulation
Objective: The main objective of this study is comparative study of natural and synthetic superdisintegrants in orodispersible Metformin tablet by using direct compression method and wet granulation method.
Method: Orodispersible Metformin tablet were prepared by wet granulation method and direct compression method by using different synthetic and natural superdisintegrants. Orodispersible tablets (ODTs) have received more interest in the pharmaceutical industry for their easy to use and self medication. ODTs overcome the problem of dysphagia (difficulty in swallowing) in the all group age of patients and advantage particularly for the paediatric and geriatric patients. Metformin hydrochloride (Hcl) is an orally administered antihyperglycemic agent, used in the management of non-insulin dependent (type-2) diabetes mellitus. Metformin orodispersible tablet is prepared by using two methods i.e. direct compression method and wet granulation method. Both methods are applied to prepare Orodispersible Metformin tablet. Orodispersible tablet of Metformin was prepared by using superdisintegrants from both natural and synthetic origin. In natural superdisintegrants we used the mucilage of Fenugreek and Lepidium sativum. In synthetic superdisintegrants we used crospovidone and sodium starch glycolate.
Conclusion: In direct compression and wet granulation method final blend and granules were evaluated the flow properties like bulk density, tapped density, compressibility index, hausner’s ratio and angle of repose. The values of precompression parameter evaluated were found to be within the prescribed limit and indicated good flow properties. The data obtained from the post compression methods was studied. Other parameters such as wetting time, water absorption ratio were also evaluated. The formulation (F5) containing 10% crospovidone prepared by wet granulation method was found the optimize formulation.
Keywords:
Downloads
References
2. Kumar R, Garg S, Chandra A, Sharma VK. Orodispersible Tablets: A splendid Form of Oral Delivery System-An Update Review. IJPBA. 2016; 7(4):1-12.
3. Pagar R, Ahir SR, Yallatikar T, Wagh M. Review on Orodispersible Tablets. IJPRS.2015; 1(4):302-3.
4. Chandrasekhar R, Hassan Z, Alhusban F, Smith MA, Mohammad RA. The role of Formulation Excipients in the Development of Lyophilised Fast-disintegrating Tablets. European Journal of Pharmaceutics and Biopharmaceutics.2009; 72:119-29.
5. Kilor V, Bramhe NN. Development of Effective Extraction Method for Lepidium SativumSeed Mucilage with Higher Yield. JAPER. 2014; 4(3):354-60.
6. Shirsand SB, Suresh S, Para MS, Swamy PV, Kumar DN. Plantago Ovate Mucilage in the Design of Fast Disintegrating Tablets. IJPS. 2009; 71(1):41-6.
7. Gandhi PP, Vaidya KA, Shelak GT, Yadav JD, Kulkarni PR. Formulation and Evaluation of Metformin Hydrochloride Fast Disintegrating Tablets by using Polacriline Potassium NF from Different Source as Superdisintegrants. IJPPS.2010; 2(2):55-7.
8. Elkhodiary KA, Hassan MA, Afifi SA. Formulation and Optimization of Orodispersible Tablets of Flutamide. Saudi Pharmaceutical Journal.2014; 22:53-61.
9. Mohapatra A, Parikh RK, Gohrl MC. Formulation Development and Evaluation of Patient Friendly Dosage Form of Metformin, part-1: Orally Disintegrating Tablets.AJP, 2008; 167-71.
10. Rani PA, Archana N, Teja SP, Vikas MP, Kumar SM, Sekaran BC. Formulation and Evaluation of Orodispersible Metformin Tablets: A Comparative Study on Isphagula Husk and Crospovidone as Superdisintegrants. IJAP. 2010; 2(3):15-21.
11. Sachan AK, Gupta A. Formulation and Evaluation of Bilayer Tablets of Nitazoxanide. Der pharmacialettre. 2017; 9(7):1-9.
12. Pavia DL, Lampman GM, Kriz GS. Introduction to spectroscopy. 3rd ed. United states of America: Thomas Learning; 2001. p. 25-33.
13. Indian Pharmacopeia. 3rd ed. Government of India, Controller ofPublications: New Delhi; 2007. p. 740-42.
14. Jaya S, Amala V. Formulation and In-vitroEvaluation of Oral Disintegrating Tablets of Amlodipine Besylate. IJAP. 2019; 11(1): 49-54.
15. Ansel HC, Popovich NG, Allen LV. Pharmaceutical dosage forms anddrug delivery systems. 4th ed. Wolter Kluwer:LippioncottWillians and Wilkins; 1995. p. 340-89.
16. Aulton ME. Aulton’s pharmaceutics. The design and manufacture of medicines.3rd ed. Churchill Livingstone: Elsiever Publication; 2007. p. 254-96.
17. Dave V, Yadav RB, Ahuja R, Yadav S. Formulation Design and Optimization of Novel Fast Dissolving Tablet of Chlorphemiramine Maleate by using Lyophilzation Techniques. Bulletin of Faculty of Pharmacy, Cairo University.2017; 55:31-9.
18. Indian Pharmacopeia. 3rd ed. Government of India, Controller of Publications; New Delhi: 2007. p. 354-5
19. Senthil A, Sivakumar T, Narayanaswamy VB, Ashish SP, Viral GP. Formulation and Evaluation of Metoprolol Tartarate by Direct Compression using Super Disintegrants.IJRAP. 2011; 2(1):224-9.
20. ICH Harmonised Tripartite Guideline. Stability testing of new drug substances and products Q1A (R2); Current Step 4 version: 2003. p. 3-6.
21. Sachan AK, Tripathi K, Vishnoi G, Rasheed A, Sharma R, Gangwar SS. Formulation Development and Characterization of Piroxicam Fast Dissolving Tablets Approved for the Treatment of Arthritis. IJDR. 2015; 5(2): 3440-46.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.