THE EFFECT OF COMBINATION OF ANTACID AND CIPROFLOXACIN ON BIOAVAILAIBILITY OF CIPROFLOXACIN

the effect of the antacid administration time interval on the pharmacokinetic parameter values ​​of ciprofloxacin

Authors

  • Parhan idr North Sumatera University
  • Edy Suwarso Department of Pharmacology, Masters Pharmacy, Faculty Pharmacy, North Sumatra University

DOI:

https://doi.org/10.22270/ajprd.v7i2.495

Keywords:

ciprofloxacin, antacids, bioavailability, high performance liquid Chromatography

Abstract

Most people use drugs at the same time. This concomitant use is susceptible to interaction which results in reduced bioavailability of one of the drugs. Ciprofloxacin is often used to prevent gram-positive and negative bacterial infections. One of them is for gastrointestinal infections. This causes most of the use of ciprofloxacin often combined with antacids. Fluoroquinolone antibiotics, one of which is ciprofloxacin when given together with antacids, can cause chelate compound formation. This causes a reduced bioavailability of ciprofloxacin in the body. The purpose of this study was to see the differences in the bioavailability of single ciproloxacin with the bioavailability of ciprofloxacin in combination with antacids. Analysis of ciprofloxacin levels in the blood was analyzed using a High Performance Liquid Chromatography (HPLC) apparatus. The results showed a significant difference between the bioavailability parameters of a single ciprofloxacin against the bioavailability of a combination antacid Ciprofloxacin. ciprofloxacin in combination with antacids has different bioavailability with single ciprofloxacin

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Author Biography

Edy Suwarso, Department of Pharmacology, Masters Pharmacy, Faculty Pharmacy, North Sumatra University

Department of Pharmacology, Masters Pharmacy, Faculty Pharmacy, North Sumatra University

References

1. Cipolle, Strand, Morley. Pharmaceutical Practice. USA: The McGraw-Hill Companies, Inc 1998: 73.
2. Sulistiati TP. Potensial Interaksi Obat Pada Pasien Tifoid Di Instalasi Rawat Inap RSUD “X” Tahun ,Universitas Muhammadiyah Surakarta 2013:2
3. Allahverdivey AM, Kon KV, Abamor ES, Bagirova M, Rafailovich M. Coping With Antibiotic Resistance: Combining Nanoparticle With antibiotics And Other Antimicrobioal Agents. Expert Reviews of Anti-infective Therapy, 201; 9(11):1035-1052.
4. Izzah Z, Gratia V, Aryani T. Suharjono. Effect of Attapulgite on The Oral Bioavailability of Ciprofloxacin. Indonesian Journal of Clinical Pharmacy, 2013; 2(2):51-56
5. Radji, M. 2015. Buku Ajar Mikrobiologi Panduan Mahasiswa Farmasi dan Kedokteran. Jakarta: EGC.
6. Brown P, De Antonis. High-Performance Liquid Chromatography. In: F.A. Settle (eds). Handbook of Instrumental Techniques for Analytical Chemistry. New Jersey: Prentice-Hall, Inc: 1997; 149-154
7. Hemanth K, Chandra I, Geetha R, Chelvi KS, Lalitha V, Prema G, A validated high-performance liquid chromatography method for the determination of rifampicin and desacetyl rifampicin in plasma and urine. Indian J Pharmacol 2004; 36(4):231-233.
8. Uivarosi V. Metal Complexes of Quinolone Antibiotics and Their Application: An Update. Molecules 2013; 18(9):11153–11197.
9. Kalra SP, Naithani N, Mehta SR, and Swamy AJ. Current Trends in the Management of Typhoid Fever. MJAFI 2003; 59:130-135.
10. Menkes RI. Keputusan Menteri Kesehatan RI No. 364/Menkes/SK/V/2006 tentang Pedoman Pengendalian Demam Tifoid. Jakarta: Departemen Kesehatan Republik Indonesia 2006.
11. Nelwan R. Tata Laksana Terkini Demam Tifoid 2012; 39 (4): 247-250.
12. Sarwade SS, Jadhav WN, Khade WN. Characteriztion of Novel Complex Ciprofloxacin Ag(I). Scholar Research Library 2015: 36-41.
13. Singh R, Debnath A, Masram DT, Rathore D. Synthesis and Biological Activities of Slected Quinolone Metal Complexes. Research Journal Of Chemical Sciences 2013; 3(6):83-94
14. Harmita A, Hayun, Harahap Y. Kimia Medisinal. Jakarta: Penerbit Buku Kedokteran EGC 2008.
15. Kazakevich Y, and L LoBrutto. Introduction. In: Kazakevich and L. LoBrutto (eds). HPLC for Pharmaceutical Scientists. New Jersey: John Wiley & Sons, Inc 2007:18-19.
16. Khopkar SM. Konsep Dasar Kimia Analitik. Jakarta: UI Press 2008.
17. Lacy CF, Armstrong LL, Goldman MP, and Lance LL. Drug Information Handbook. 13¬th edition, Lexi-Comp for the American Pharmacists Association 2005.
18. McMaster MC. HPLC A Practical User’s Guide, 2nd Edition. New Jersey: John Wiley & Sons, Inc 2007:106.
19. Ornaf RM, and MW Dong. Key Concepts of HPLC in Pharmaceutical Analysis. In: S. Ahuja and M.W. Dong (eds). Handbook of Pharmaceutical Analysis by HPLC. San Diego: Elsevier 2005: 22-29.
20. Rohman A. Kimia Farmasi Analisis. Yogyakarta. Pustaka Pelajar 2007; (1): 465-469.
21. Setiabudy R. Pengantar Anti mikroba dalam: Gunawan S.G., editor. Farmakologi dan Terapi. Edisi V. Jakarta: Departemen Farmakologi dan Terapeutik Fakultas Kedokteran Universitas Indonesia 2007: 453-454
22. Setiadarma K. Asas Pengembangan Prosedur Analisis. Surabaya; Airlangga University Press 2004: 63
23. Shargel L, Andrew BC. Biofarmasetika Dan Farmakokinetika Terapan. Alih Bahasa Fasich, Siti Sjamsiah. Surabaya: Airlangga University Press 1988; 103-115
24. Sukandar EY, Andrajati R, Sigit JL, Andyana IK, Setiadi AAP, dan Kusnandar. ISO Farmakoterapi. Jakarta: Penerbit PT. ISFI Penerbitan 2008; (1): 97
25. Sweetman SC. Martindale The Complete Drug Reference 36th Edition. Grayslake: Pharmaceutical Press 2009; 552
26. Snyder LR, and Kirkland JJ. Introduction to Modern Liquid Chromatography, 2nd Edition. New York: John Wiley & Sons, Inc 1979; 52, 250.
27. Tan HT, Rahardja K. Obat-obat Penting, Khasiat, Penggunaan, dan Efek Samping. Jakarta: PT. Elex Media Komputindo 2010; (6):253.
28. Watson DG. Analis Farmasi. dalam: Buku Ajar Untuk Mahasiswa Farmasi Dan Praktisi Kimia Farmasi. Jakarta: EGC 2010;105

Published

2019-04-15

How to Cite

idr, P., & Suwarso, E. (2019). THE EFFECT OF COMBINATION OF ANTACID AND CIPROFLOXACIN ON BIOAVAILAIBILITY OF CIPROFLOXACIN: the effect of the antacid administration time interval on the pharmacokinetic parameter values ​​of ciprofloxacin. Asian Journal of Pharmaceutical Research and Development, 7(2), 11–14. https://doi.org/10.22270/ajprd.v7i2.495

Issue

Vol. 7 No. 2 (2019): Volume 7 Issue 2 March - April 2019

Section

Research Articles

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