ANTI-DIABETIC EFFECTS OF SOME MEDICINAL PLANTS IN EXPERIMENTAL ANIMALS: A REVIEW

Authors

  • Mudasir Maqbool University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India
  • Imran Gani University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India
  • Mohmad Amin Dar University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India

DOI:

https://doi.org/10.22270/ajprd.v7i1.469

Keywords:

Diabetes, experimental animals, Madhumeha

Abstract

Diabetes is a chronic endocrine disease with global prevalence and increasing incidence. Diabetes presents with a major health issue in all age groups in the present times owing to its multisystem involvement and serious complications. In spite of drug development and therapeutic interventions, successful treatment of diabetes still remains a challenge and worldwide research is focused on finding alternative modalities. By conducting sizable amount of analytical work, numerous traditional medicines have been found for diabetes. Substances and extracts isolated from completely different natural resources particularly plants have perpetually been a fashionable arsenal for dominant and treating polygenic disorders downside and complication arising because of it. Many medicinal plants have shown promising effects in experimental animals which can be extrapolated to humans also. In this paper, we will review various medicinal plants showing anti-diabetic activity in experimental animals.

Downloads

Download data is not yet available.

Author Biographies

Mudasir Maqbool, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India

Imran Gani, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India

Mohmad Amin Dar, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India

Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal Srinagar, Jammu and Kashmir, India

References

1. Modak D; A Review: Anti-Diabetic Activity of Herbal Drugs; PharmaTutor; 2015; 3(9); 36-42.
2. Yatoo MI, Saxena A, Gopalakrishnan A, Alagawany M, Dhama K, Promising Antidiabetic Drugs, Medicinal Plants and Herbs: An
Update. Intern J Pharmacol, 2017; 13: 732-745.
3. Modak M, Dixit P, Londhe J, et al. Indians herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007; 40:163-73.
4. Park H, Hwang KY, Kim YH, Oh KH, Lee JY, Kim K, “Discovery and Biological Evaluation of Novel α-Glucosidase Inhibitors with in Vivo Antidiabetic Effect,” Bioorganic & Medicinal Chemistry Letters, 2008; 18: 3711-3715. doi:10.1016/j.bmcl.2008.05.056.
5. Seema PV, Sudha B, Pius SP, Asha A, Raghu KG, Paulose CS, Kinetic study of purified malate dehydrogenase in liver STZ-diabetic rats and the effect of leaf extract of Aegle marmelose (L) correa ex Roxb. Ind. J Expt. Biol, 1996; 34: 600-2.
6. Sabu M.C., Kuttan Ramadasan,. Antidiabetic activity of Aegle marmelos and its relationship with antioxidant properties. Ind. J. Pharmacol. 2004;48(1): 81-88.
7. Augusti KT, Ind. J Exp Biol. 1976; 14(2): 110-12.
8. Gupta RK, Gupta S, Samuel KC, Indian J Exp Biol. 1977; 15(4):313-14.
9. Bopanna KN, Kannan J, Sushma G, Balaraman R, Rathod SP,. Antidiabetic and antihyperlipaedemic effects of neem kernel powder on alloxan diabetic rabbits. Ind J Pharmacol. 1997;29: 162-7.
10. Chattopadhyay RR, Possible mechanism of antihyperglycemic effect of Azadiracht 167 extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats.J. Ethnopharmacol., 1996;76: 269-277.
11. Sharma SR, Dwivedi SK, Swarup D, Hypoglycemic, antihyperglycemic and hypolipidemic activity of Caesalpinia bouducella seeds in rats. J Ethnopharmacol. 1997; 58: 39-44.
12. Poonam Y, Sarkar S, Bhatnagar D,. Lipid peroxidation and antioxidant enzymes in erythrocytes tissue in aged diabetic rats. Ind J Exp Biol. 1997; 35: 389-92.
13. Som Nath Singh, Praveen Vats, Shobha Suri, Radhey Shayam, Kumari M.M.L., Ranganathan R., Sridharan K.,. Effect of an antidiabetic 167 extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats.J. Ethnopharmacol., 2001;76: 269-277.
14. Brahmachari HD, Augasti KT,. J Pharm Lond. 1963; 15(6): 411-12.
15. Azad Khan AK, Akhtar S, Mahtab H, Coccina indica in the treatment of patients with DM. Bangladesh Med. Res Counc Bull. 1979; 5(2): 60.
16. Cherian S, Augasti KT, Antidiabetic effects of a glycoside of leucopelargonidin isolated from Ficus bengalonsis Lin. Ind J Exp Biol. 1993;31(1): 26.
17. Jain SR, Sharma SN, Planta Med 1967; 15(4): 439-42.
18. Guruswami MN, Lalitha K, Gopal S, Curr Med Prac 1959; 3(5): 227-32.
19. Shanmugasundaram KR, Panneerselvam C, Samudram P, et al., The isulinotropic activity of Gymnema slyvestra RBr. And Indian medicinal Herbs in controlling Diabetes. Pharmacol Res Commun 1981,13: 475.
20. Prakash AO, Mathur S, Mathur R,effect of feeding Gymnema slyvestra leaves on blood glucose in beryllium nitrate trated rats. J Ethnopharmacol. 1986; 18: 143.
21. Shanmugasundaram ER, Rajeshwari G, Baskaran K, et al,. Gymnema slyvestra leaf extract in control of glucose in IDDM. J Ethnopharmacol. 1990; 30: 281.
22. Shanmugasundaram KR, Panneerselvam C, Samudram P, et al., Enzyme change and glucose utilization in diabetic rabbits: the effect of Gymnema slyvestra R. Br. J Ethnopharmacol. 1983; 7: 205.
23. Chatterjee KP,. Ind J Phy Pharmacol. 1963; 7(4): 240-44.
24. Higashino H, Suzuki A, Tanaka Y, et al., Hypoglycemic effects of Siamese Momordica charantia and Phyllanthus urinary extracts in STZdiebetic rats (the 1 st report). Nippon Yakurigaru Zasshi 1992;100: 415.
25. Ahmed I, Adeghate E, Sharma AK, et al., Effect of Momordica charantia fruit juice on islet morphology in the pancreas of the STZ-diabetic rats. Diabetes Res Clin. Pract, 40: 145.
26. Sitasawad SL, Shewade Y, Bhonde R, 2000. Role of bittergourd fruit juice in stz-induced diabetic state in vivo and in vitro. J Ethnopharmacol. 73: 71.
27. Matsuda H Li Y, Yamahara J, et al., Inhibition of gastric empting by triterpine saponin, momordin Ic, in mice: role of blood glucose, capsicin- 168 sensitivity sensory nerve, and central nervous system. J Pharmacol Exp Ther. 1999;289: 729.
28. Pandey MC, Sharma PV, 1975. Med & Surg. 15(11): 21-24.
29. Manickam M, Ramnathan M, Jahromi MA, et. al.,. Antihyperglycemic activity of phenols from Pterocarpus marsupium. J Nat Prod. 1997;60: 609-10.
30. Rizvi SI, Zaid MA, Insulin mimetic effect of epicatechin on osmotic fragility of human erythrocytes. Ind J Exp Biol. 1995; 35: 791-2.
31. Prince PS Mainzen, Kamalakkannan N, Menon VP, Antidiabetic and antihyperlipidademic effect of alcoholic Syzigium cumini seeds in alloxan diabetic albino rats. J Ethnopharmacol. 2004; 91: 209-213.
32. Khosla P, Gupta DD, Nagpal RK,. Effect of Trigonella foenum graecum on blood glucose in normal and diabetic rats. Indian J Physiol Pharmacol. 1995; 39: 173-4.
33. Akhani SP, Vishwakarma SL, Goyal RK, Anti-diabetic activity of Zingiber officinale in stz-induced type I diabetic rats. J Pharm Pharmacol. 2004; 56: 101-105.
34. Ignacimuthu S, Amalraj T, Effect of leaf extract of Zizyphus jujube on diabetic rats. Indian J Pharmacol. 1998; 30: 107-8.
35. Dubey GP, Dixit SP, Alok S, Alloxan induced diabetes in rabbits and effect of a herbal formula D-400. Indian J Pharmacol. 1994; 26: 225-6.
36. Dhawan D, Bandhu HK, Sing B, Ajaib S, Nagpal JB, Effects of D400 on the regulation of glucose metabolism in diabetic rats. Indian J Pharmacol. 1996; 28: 224-6.
37. Pandey VN, Rajagopalan SS, Chawdhary DP, An effective Ayurvedic hypoglycemic formula. J Res Ayurveda Siddha. 1995; 16: 1.
38. Sircar AR, Ahuja RC, Natu SM, et. al., Hypoglycemic, hypolipidemic and general beneficial effects of an herbal mixture MA-471. Altern Ther Clin Pract. 1996; 3: 26.

Published

2019-02-15

How to Cite

Maqbool, M., Gani, I., & Dar, M. A. (2019). ANTI-DIABETIC EFFECTS OF SOME MEDICINAL PLANTS IN EXPERIMENTAL ANIMALS: A REVIEW. Asian Journal of Pharmaceutical Research and Development, 7(1), 66–69. https://doi.org/10.22270/ajprd.v7i1.469