FORMULATION DESIGN AND OPTIMIZATION OF ORAL FLOATING MATRIX TABLETS OF CIPROFLOXACIN HCL BY USING HPMC AND XANTHAN GUM WITH EXPERIMENTAL DESIGN
DOI:
https://doi.org/10.22270/ajprd.v6i6.430Keywords:
Oral floating matrix tablets; Experimental design; HPMC K100M; Xanthan gum; Ciprofloxacin Hydrochloride.Abstract
The oral floating matrix tablets of Ciprofloxacin Hydrochloride were formulated by Experimental design by using HPMC K100M and Xanthan gum as the retardant polymers each with three different levels with an approach to increase gastric residence and thereby improve drug bioavailability. From FTIR results confirm the absence of chemical interaction between the drug with the excipients used in tablet formulations. Also, there was no shift in the endotherm of in the drug- excipients mixtures indicating compatibility of drug with all the excipients. All the tablets were prepared by effervescent approach in which Sodium bicarbonate was added as a gas generating agent. Floating Matrix tablets were prepared by direct compression method and prepared tablets were evaluated for weight variation, percentage friability, hardness and drug content studies. All the formulations showed compliance with pharmacopeia standards. Floating lag times of all the formulations were within 1 minute and Total floating time of all the formulations were more than 12 hours. In vitro release studies revealed that the release rate decreased with increase polymer proportion of retarding polymers. The formulation CHX8 sustained release of drug for 12 hrs with 20% release of drug after 1hr and more than 97% at the end of 12 hrs. From the Kinetic model it was found that the optimized formulation CHX8 showed linearity in case of Zero order (R2: 0.952) and Higuchi model (R2: 0.948). By fitting data to Korsmeyer-Peppas model and ‘n’ value lying above 0.5 indicating non Fickian release.
Downloads
References
2. Kataria S, Middha A, Bhardwaj S, Sandhu P. Floating drug delivery system a review. Int Res J of pharmacy 2011; 2(9): 18-24.
3. Venketasurlu K, Jami KP, Badithala SSK. Floating drug delivery system of ciprofloxacin HCl. Asian J Pharma 2016; 10(4): 271-278.
4. Abbas N, Ahsan M, Hussain A, Saeed H, Shah PA, Mohammad S, Arshad MS. Formulation Optimization and In-vitro Evaluation of Oral Floating Captopril Matrix Tablets using Factorial Design. Tropical J Pharma Res 2015; 14(10): 1737-1748.
5. Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eu J Pharma Sci 2001; 13: 123–133.
6. Varshosaz J, Tavakoli N, Kheirolahi F. Use of hydrophilic natural gums in formulation of sustained-release matrix tablets of tramadol hydrochloride. AAPS Pharm Sci Tech. 2006; 7(1): E1-E7.
7. Shoaib MH, Tazeen J, Merchant HA, Yousuf RI. Evaluation of drug release kinetics from Ibuprofen matrix tablets using HPMC. Pak J Pharm Sci 2006; 19(2): 119-124.
8. Devarajan K, Rangasamy M, Selvaraj J and Natesan SK. Development and evaluation of floating tablets of ciprofloxacin Hcl. Int. journal of pharm and allied sciences archive 2012 april-june; 1(1):17-25.
9. Reddy KR, Mutalik S, Reddy S. Once-daily sustained-release matrix tablets of Nicorandil: Formulation and in vitro evaluation. AAPS Pharm Sci Tech 2003; 4 (4): 1-9.
10. Khemariya P, Jain AK, Bhargava M, Singhai SK, Goswami S, Goswami R. Preparation and in-vitro evaluation of sustained-release matrix tablets of Diltiazem. Int J Adv Pharm Sci 2010; 1: 267-273
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).