FISH MUCUS: A NEGLECTED RESERVOIR FOR ANTIMICROBIAL PEPTIDES
DOI:
https://doi.org/10.22270/ajprd.v6i4.389Keywords:
mucus, peptides, antimicrobial, fish, drugAbstract
Antimicrobial resistance has posed a great global burden, with the fear that by 2050 it would have killed more people than cancer if nothing much is done about it. Alongside several attempts in place, zoo-therapy is becoming one of important remedies in the modern society, with hope for solution believed to be hidden in nature. In this study, the authors present a review of journal articles and reports obtained through key word search of several literature databases on recent developments in the battle against the antimicrobial resistance using fish derived antimicrobial peptides. The findings indicate despite some limitations of these antimicrobial peptides, their very broad spectrum activity against pathogens keeps them among promising antibiotics as far as the battle against multidrug resistance is concerned. Much as various methods to study antimicrobial peptides do exist, fish mucus remains less explored. The study recommends aquatic habitat exploration in search for novel bacterial antimicrobial peptides.
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References
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28. Broekman DC, Zenz A, Gudmundsdottir BK, Lohner K, Maier VH, Gudmundsson GH. Peptides Functional characterization of codCath , the mature cathelicidin antimicrobial peptide from Atlantic cod ( Gadus morhua ). Peptides [Internet]. 2011;32(10):2044–51.
29. Ruangsri J, Kitani Y, Kiron V, Lokesh J, Brinchmann MF, Karlsen O, et al. A Novel Beta-Defensin Antimicrobial Peptide in Atlantic Cod with Stimulatory Effect on Phagocytic Activity. PLoS One. 2013;8(4).
30. Masso-silva JA, Diamond G. Antimicrobial Peptides from Fish. Pharmaceuticals. 2014;7:265–310.
31. Rogers LA. The inhibiting effect of streptococcus lactis on lactobacillus bulgaricus. J Bacteriol. 1928;16(5):321–5.
32. Bahar AA, Ren D. Antimicrobial Peptides. Pharmaceuticals. 2013;6:1543–75.
33. Ikai Y, Oka H, Hayakawa J, Matsumoto M. Total Structures and Antimicrobial Activity of Bacitracin Minor Components components instead of CCDand it was demonstrated suggesting that our previously proposed structures14 ) are and rapidly separate the BCcomponents , isocratic HPLC groups ; BC-Aand. J Antibiot (Tokyo). 1994;48(3):233–42.
34. Townsley LE, Tucker WA, Sham S, Hinton JF. Structures of Gramicidins A , B , and C Incorporated into Sodium Dodecyl Sulfate. Biochemistry. 2001;15:11676–86.
35. Bzmka T. Properties of synthetic analogs of gramicidin S containing L-serine or L-glutamic acid residue in place of L-ornithine residue. Int J Pept Protein Res. 1996;47:369–75.
36. Dubos JR. Studies on a Bactericidal Agent Extracted from a Soil Bacillus: I. Preparation of the Agent. Its Activity in Vitro. J Exp Med. 1939;70(1939):1–10.
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38. Sankar NR, Priyanka VD, Reddy PS, Rajanikanth P, Kumar VK, Indira M. Purification and Characterization of Bacteriocin Produced by Lactobacillus plantarum Isolated from Cow Milk. Int J Microbiol Res. 2012;3(2):133–7.
39. Adnan M, Patel M, Hadi S. Functional and health promoting inherent attributes of Enterococcus hirae F2 as a novel probiotic isolated from the digestive tract of the freshwater fish Catla catla. PeerJ 5:e3085. 2017;
40. Shiba PB, Krushna CD, Supratim C. Detection , partial purification and characterization of bacteriocin produced by Lactobacillus brevis FPTLB3 isolated from freshwater fish. J Food Sci Technol. 2013;50:17–25.
41. Atta HM, Refaat BM. Application of Biotechnology for Production , Purification and Characterization of Peptide Antibiotic Produced by Probiotic Lactobacillus plantarum , NRRL B-227. Glob J Biotechnol Biochem. 2009;4(2):115–25.
42. Elavarasi K, Ranjini S, Rajagopal T. Bactericidal proteins of skin mucus and skin extracts from fresh water fishes , Clarias batrachus and Tilapia mossambicus Abstract : Thai J Pharm Sci. 2013;37:194–200.
43. Koehbach J, Gruber CW, Becker C, Kreil DP, Jilek A. MALDI TOF/TOF-Based Approach for the Identi fi cation of. 2016;
44. Uthayakumar V, Ramasubramanian V, Senthilkumar D. Biochemical characterization , antimicrobial and hemolytic studies on skin mucus of fresh water spiny eel Mastacembelus armatus. Asian Pac J Trop Biomed [Internet]. 2012;2(2):S863–9. Subramanian S, Ross NW, Mackinnon SL. Myxinidin , A Novel Antimicrobial Peptide from the Epidermal Mucus of Hagfish , Myxine glutinosa L . Mar Biotechnol. 2009;11:748–57.
45. Subramanian S, Ross NW, Mackinnon SL. Comparison of antimicrobial activity in the epidermal mucus extracts of fish. Comp Biochem Physiol. 2008;150:85–92.
46. Syed AM, Sifa A. Production and characterization of a new antibacterial peptide obtained from Aeribacillus pallidus SAT4. Biotechnol Reports. 2015;8:72–80.
47. Bergsson G, Agerberth B, Jo H. Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod ( Gadus morhua ). FEBBS J. 2005;272:4960–9.
48. Bragadeeswaran S, Priyadharshini S, Prabhu K, Raj S, Rani S. Antimicrobial and hemolytic activity of fish epidermal mucus Cynoglossus arel and Arius caelatus. Asian Pac J Trop Med 2011;4(4):305–9.
49. Mendoza VL, Vachet RW. Probing Protein Structure by Amino Acid-Specific Covalent Labeling and Mass Spectrometry. Mass spectrom. 2010;28(5):785–815.
50. Cherkasov A, Hilpert K, Fjell CD, Waldbrook M, Mullaly SC, Volkmer R, et al. Use of Artificial Intelligence in the Design ofSmall Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs. ACS Chem Biol. 2009;4(1):65–74.
51. Czyzewski AM, Jenssen H, Fjell CD, Waldbrook M, Barron E. In Vivo , In Vitro , and In Silico Characterization of Peptoids as Antimicrobial Agents. PLoS One. 2016;1–17.
52. Mahlapuu M, Håkansson J, Ringstad L, Björn C. Antimicrobial Peptides : An Emerging Category of Therapeutic Agents. Front Cell Infect Microbiol. 2016;6:1–12.
53. Lai Y, Villaruz AE, Li M, Cha DJ, Sturdevant DE, Otto M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol. 2006;63:497–506.
54. Wilcox S. The New Antimicrobials : Cationic Peptides. BioTech J. 2004;2:88–91.
55. Wade D, Bomant A, Wxhlint B, Drain CM, Andreut D, Bomant HG, et al. All-D amino acid-containing channel-forming antibiotic peptides. Biochemistry. 1990;87:4761–5.
56. Wu X, Li Z, Li X, Tian Y, Fan Y, Yu C, et al. Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug- resistant bacteria. Drug Des Devel Ther. 2017;11:939–46.
2. Xin H, Ji S, Peng J, Han P, An X, Wang S, et al. Isolation and characterisation of a novel antibacterial peptide from a native swine intestinal tract-derived bacterium. Int J Antimicrob Agents, 2016
3. Tillotson GS, Zinner SH. Burden of antimicrobial resistance in an era of decreasing susceptibility. Expert Rev Anti Infect Ther 2017;15(7):663–76.
4. WHO. Drug-resistant bacteria ranked. Nature. 2017 ;15.
5. O’Neill J. Antimicrobial Resistance : Tackling a crisis for the health and wealth of nations. London; 2014.
6. WHO. World malaria report .Geneva; 2017.
7. WHO. WHO Global Health Observatory data.Geneva; 2017.
8. WHO. World Cancer Report 2016. Geneva; 2016.
9. WHO. Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline, including tuberculosis. Geneva; 2017.
10. TheScientist. Overcoming Resistance. LabX Media Group 2014 Apr;1–10.
11. IDSA. The 10 × â€TM 20 Initiative : Pursuing a Global Commitment to Develop 10 New Antibacterial Drugs by 2010;50(8):1081–3.
12. Huttner A, Harbarth S, Carlet J, Cosgrove S, Goossens H, Holmes A. Antimicrobial resistance : a global view from the 2013 World Healthcare-Associated Infections Forum. Antimicrob Resist Infect Control. 2013;2(31):1–13.
13. Vennila R, Kumar KR, Kanchana S, Arumugam M, Vijayalakshmi S. Preliminary investigation on antimicrobial and proteolytic property of the epidermal mucus secretion of marine stingrays. Asian Pac J Trop Biomed 2011;1(2):239–43.
14. Tyor AK, Kumari S. Biochemical characterization and antibacterial properties of fish skin mucus of fresh water fish, hypophthalmichthys nobilis. Int J Pharm Pharm Sci. 2016;8(6):6–10.
15. Chinwuba T, Okafor SN, Okechukwu DC. Catfish ( Clarias gariepinus ) Slime Coat Possesses Antimicrobial and Wound Healing Activities UK Journal of Pharmaceutical and Biosciences Available at www.ukjpb.com Catfish ( Clarias gariepinus ) Slime Coat Possesses Antimicrobial and Wound Healing Acti. UK J Pharm Biosci. 2016;4(3):84–7.
16. Rahman S, Choudhury JK, Dutta A, Kalita MC. Eel Ichthyofauna of Assam in Folklore Therapeutic Practices. Int J Interdiscip Multidiscip Stud. 2014;1(5):273–6.
17. Blakeslee S. Catfish Slime â€TM s Healing Agents. The New York Times. 1988 26;C00003.
18. Deslouches B, Di YP. Antimicrobial peptides with selective antitumor mechanisms : prospect for anticancer applications. Oncotarget. 2017;8(28):46635–51.
19. Nwabueze AA, Campus A, Campus A. Antimicrobial Action of Epidermal Mucus Extract of Clarias gariepinus ( Burchell , 1822 ) Juveniles-Fed Ginger Inclusion in Diet. Int J Biol. 2014;6(2):42–8.
20. Loganathan K, Muniyan M, Prakash AA, Raja PS, Prakash M. Studies on the role of mucus from clarias batrachus ( Linn ) against studies on the role of mucus from clarias batrachus ( Linn ) against selected microbes. Int J Pharm Appl ISSN. 2014;2(3):202–6.
21. Wei ONGY, Xavier R, Marimuthu K. Screening of antibacterial activity of mucus extract of Snakehead fish , Channa striatus ( Bloch ). Eur Rev Med Pharmacol Sci. 2010;675–81.
22. Epand RM, Vogel HJ. Diversity of antimicrobial peptides and their mechanisms of action. Biochem Biophys Acta. 1999;1462:11–28.
23. Hancock RE. Review Cationic peptides : effectors in innate immunity and novel antimicrobials. Infect Dis (Auckl). 2001;1:156–64.
24. Ageitos JM, Villa TG. Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria. Biochem Pharmacol 2016
25. Jackson GS, Beck JA, Sutton PM, Contreras M, Collinge J. Peptide antibiotics in mast cells of fish. Nature,. 2001 :268–70.
26. Cole AM, Weis P, Diamond G. Isolation and Characterization of Pleurocidin , an Antimicrobial Peptide in the Skin Secretions of Winter Flounder *. J Biol Chem. 1997;272(18):12008–13.
27. Chang C, Zhang Y, Zou J, Nie P, Secombes CJ. Two Cathelicidin Genes Are Present in both Rainbow Trout ( Oncorhynchus mykiss ) and Atlantic Salmon ( Salmo salar ). Antimicrob Agents Chemother. 2006;50:185–95.
28. Broekman DC, Zenz A, Gudmundsdottir BK, Lohner K, Maier VH, Gudmundsson GH. Peptides Functional characterization of codCath , the mature cathelicidin antimicrobial peptide from Atlantic cod ( Gadus morhua ). Peptides [Internet]. 2011;32(10):2044–51.
29. Ruangsri J, Kitani Y, Kiron V, Lokesh J, Brinchmann MF, Karlsen O, et al. A Novel Beta-Defensin Antimicrobial Peptide in Atlantic Cod with Stimulatory Effect on Phagocytic Activity. PLoS One. 2013;8(4).
30. Masso-silva JA, Diamond G. Antimicrobial Peptides from Fish. Pharmaceuticals. 2014;7:265–310.
31. Rogers LA. The inhibiting effect of streptococcus lactis on lactobacillus bulgaricus. J Bacteriol. 1928;16(5):321–5.
32. Bahar AA, Ren D. Antimicrobial Peptides. Pharmaceuticals. 2013;6:1543–75.
33. Ikai Y, Oka H, Hayakawa J, Matsumoto M. Total Structures and Antimicrobial Activity of Bacitracin Minor Components components instead of CCDand it was demonstrated suggesting that our previously proposed structures14 ) are and rapidly separate the BCcomponents , isocratic HPLC groups ; BC-Aand. J Antibiot (Tokyo). 1994;48(3):233–42.
34. Townsley LE, Tucker WA, Sham S, Hinton JF. Structures of Gramicidins A , B , and C Incorporated into Sodium Dodecyl Sulfate. Biochemistry. 2001;15:11676–86.
35. Bzmka T. Properties of synthetic analogs of gramicidin S containing L-serine or L-glutamic acid residue in place of L-ornithine residue. Int J Pept Protein Res. 1996;47:369–75.
36. Dubos JR. Studies on a Bactericidal Agent Extracted from a Soil Bacillus: I. Preparation of the Agent. Its Activity in Vitro. J Exp Med. 1939;70(1939):1–10.
37. Eid R, J EJ, Rashidy A, Asfour H, Omara S, Mm K, et al. Probiotics & Health Potential Antimicrobial Activities of Probiotic Lactobacillus Strains Isolated from Raw Milk. J Probiotics Heal. 2016;4(2):2–9.
38. Sankar NR, Priyanka VD, Reddy PS, Rajanikanth P, Kumar VK, Indira M. Purification and Characterization of Bacteriocin Produced by Lactobacillus plantarum Isolated from Cow Milk. Int J Microbiol Res. 2012;3(2):133–7.
39. Adnan M, Patel M, Hadi S. Functional and health promoting inherent attributes of Enterococcus hirae F2 as a novel probiotic isolated from the digestive tract of the freshwater fish Catla catla. PeerJ 5:e3085. 2017;
40. Shiba PB, Krushna CD, Supratim C. Detection , partial purification and characterization of bacteriocin produced by Lactobacillus brevis FPTLB3 isolated from freshwater fish. J Food Sci Technol. 2013;50:17–25.
41. Atta HM, Refaat BM. Application of Biotechnology for Production , Purification and Characterization of Peptide Antibiotic Produced by Probiotic Lactobacillus plantarum , NRRL B-227. Glob J Biotechnol Biochem. 2009;4(2):115–25.
42. Elavarasi K, Ranjini S, Rajagopal T. Bactericidal proteins of skin mucus and skin extracts from fresh water fishes , Clarias batrachus and Tilapia mossambicus Abstract : Thai J Pharm Sci. 2013;37:194–200.
43. Koehbach J, Gruber CW, Becker C, Kreil DP, Jilek A. MALDI TOF/TOF-Based Approach for the Identi fi cation of. 2016;
44. Uthayakumar V, Ramasubramanian V, Senthilkumar D. Biochemical characterization , antimicrobial and hemolytic studies on skin mucus of fresh water spiny eel Mastacembelus armatus. Asian Pac J Trop Biomed [Internet]. 2012;2(2):S863–9. Subramanian S, Ross NW, Mackinnon SL. Myxinidin , A Novel Antimicrobial Peptide from the Epidermal Mucus of Hagfish , Myxine glutinosa L . Mar Biotechnol. 2009;11:748–57.
45. Subramanian S, Ross NW, Mackinnon SL. Comparison of antimicrobial activity in the epidermal mucus extracts of fish. Comp Biochem Physiol. 2008;150:85–92.
46. Syed AM, Sifa A. Production and characterization of a new antibacterial peptide obtained from Aeribacillus pallidus SAT4. Biotechnol Reports. 2015;8:72–80.
47. Bergsson G, Agerberth B, Jo H. Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod ( Gadus morhua ). FEBBS J. 2005;272:4960–9.
48. Bragadeeswaran S, Priyadharshini S, Prabhu K, Raj S, Rani S. Antimicrobial and hemolytic activity of fish epidermal mucus Cynoglossus arel and Arius caelatus. Asian Pac J Trop Med 2011;4(4):305–9.
49. Mendoza VL, Vachet RW. Probing Protein Structure by Amino Acid-Specific Covalent Labeling and Mass Spectrometry. Mass spectrom. 2010;28(5):785–815.
50. Cherkasov A, Hilpert K, Fjell CD, Waldbrook M, Mullaly SC, Volkmer R, et al. Use of Artificial Intelligence in the Design ofSmall Peptide Antibiotics Effective against a Broad Spectrum of Highly Antibiotic-Resistant Superbugs. ACS Chem Biol. 2009;4(1):65–74.
51. Czyzewski AM, Jenssen H, Fjell CD, Waldbrook M, Barron E. In Vivo , In Vitro , and In Silico Characterization of Peptoids as Antimicrobial Agents. PLoS One. 2016;1–17.
52. Mahlapuu M, Håkansson J, Ringstad L, Björn C. Antimicrobial Peptides : An Emerging Category of Therapeutic Agents. Front Cell Infect Microbiol. 2016;6:1–12.
53. Lai Y, Villaruz AE, Li M, Cha DJ, Sturdevant DE, Otto M. The human anionic antimicrobial peptide dermcidin induces proteolytic defence mechanisms in staphylococci. Mol Microbiol. 2006;63:497–506.
54. Wilcox S. The New Antimicrobials : Cationic Peptides. BioTech J. 2004;2:88–91.
55. Wade D, Bomant A, Wxhlint B, Drain CM, Andreut D, Bomant HG, et al. All-D amino acid-containing channel-forming antibiotic peptides. Biochemistry. 1990;87:4761–5.
56. Wu X, Li Z, Li X, Tian Y, Fan Y, Yu C, et al. Synergistic effects of antimicrobial peptide DP7 combined with antibiotics against multidrug- resistant bacteria. Drug Des Devel Ther. 2017;11:939–46.
Published
2018-08-23
How to Cite
Hedmon, O. (2018). FISH MUCUS: A NEGLECTED RESERVOIR FOR ANTIMICROBIAL PEPTIDES. Asian Journal of Pharmaceutical Research and Development, 6(4), 6–11. https://doi.org/10.22270/ajprd.v6i4.389
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Review Articles
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