ANTIINFLAMMATION ACTIVITY ETHANOL EXTRACT OF MARBOSI-BOSI LEAVES (Tarenna polycarpa (Miq.) Koord.Ex Valeton) ON WHITE RAT IN CARRAGEENAN INDUCED PAW INFLAMMATION
DOI:
https://doi.org/10.22270/ajprd.v6i3.376Keywords:
Antiinflammation, Marbosi-Bosi, Rat Paw, Edema, CarrageenanAbstract
Traditionally, (Tarenna polycarpa (Miq.) Koord Ex Valeton as known as marbosi-bosi which commonly found in Sibolga, North Sumatera, Indonesia has been used as antidiabetes, cholesterol, anti-inflammatory and antibacterial. Tarenna species has been found its activities as antimicrobial, anti-oxidant and anti-inflammatory activity. The aim of this study was to investigate the anti inflammatory effect ethanol extract of marbosi-bosi leaves (Tarenna polycarpa (Miq.) Koord Ex Valeton in terms of decreased edema volume of male white rat in 1% carrageenan-induced and also to determine the effective dose of extract to decrease the volume of rat paw edema Ethanol extract of marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton was obtained by maceration. The antiinflammatory activity test was divided into 5 groups. The Group I (negative control) was given CMC 0.5%, Group II (positive control) was given diclofenac sodium 2,25 mg / kg BW, while Group III, IV and V were given marbosi-bosi leaf extract at a dose of 50, 100 and 200 mg/kgBW respectively. Each rat was induced by 1% carrageenan subplantar injection. Examination of antiinflammatory effect was measured by using digital plethysmometer at minute of 30 to minute of 360. The data were analyzed statistically using ANOVA (analysis of variance).The results showed that negative control did not show anti-inflammatory effect had significant differences with other treatment groups. In conclusion, ethanol extract marbosi-bosi (Tarenna polycarpa (Miq.) Koord Ex Valeton has an effective anti-inflammatory activity at a dose of 100 mg / kgBW.
Downloads
References
2. Kuntze ES. Anjanadevi N, Abirami P., and Sharmila S. Antibacterial Activity of Leaf Extract of Tarenna Asiatica (L.). Indian Journal Microbiology Sciences. 2014; 3 (10). 48-51.
3. Ramabharathi V. Phytochemical investigation of gum-resin of Tarenna asiatica and evaluation of its biological activities. M. Pharm (Doctoral dissertation, Dissertation. Sri Padmavati Mahila Visvavidyalayam (Women’s University), Tirupati). 2011; 3-9.
4. Amutha D, Shanthi S, Mariappan V. Antiinflammatory effect of Tarenna asiatica in carrageenan induced lung inflammation. Int J Pharm Pharmaceut Sci. 2012;4:344-47.
5. Sari RP. Antioxidant And Antidiabetes Activity of Ethanol Extract And Morbesi-besi Leaf Fraction (tarenna polycarpa) (miq.) Choir. ex valenton) In Streptozotocin Induction, Against Mice. Theses: Universitas Sumatera Utara.2017; 21, 25.
6. Nijveldt RJ, Van Nood EL, Van Hoorn DE, Boelens PG, Van Norren K, Van Leeuwen PA. Flavonoids: a review of probable mechanisms of action and potential applications–. The American journal of clinical nutrition. 2001 Oct 1;74(4):418-25.
7. Oršolić N, Bašić I. Propolis and plant flavonoids in human allergies and inflammations. Scientific evidence of the use of propolis in ethnomedicine. Ethnopharmacology-Review Book, Transworld Research Network, India. 2008 Jan 1:337-76.
8. Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview. The Scientific World Journal. 2013;2013.
9. Leyva-López N, Gutierrez-Grijalva EP, Ambriz-Perez DL, Heredia JB. Flavonoids as cytokine modulators: a possible therapy for inflammation-related diseases. International journal of molecular sciences. 2016 Jun 9;17(6):921
10. Balloy V, Huerre M, Latgé JP, Chignard M. Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis. Infection and immunity. 2005 Jan 1;73(1):494-503.
11. Vogel HG, editor. Drug discovery and evaluation: pharmacological assays. Springer Science & Business Media; 2002 Jun 13; 759-760, 767-768.
12. Yu D, Yuan Y, Jiang L, Tai Y, Yang X, Hu F, Xie Z. Anti-inflammatory effects of essential oil in Echinacea purpurea L. Pak. J. Pharm. Sci. 2013 Mar 1;26(2):403-8.
13. Fitriyani A, Winarti L, Muslichah S, Nuri N. Anti-inflammatory Activityy of Piper crocatum Ruiz & Pav. Leaves metanolic extract in rats. Majalah Obat Tradisional (Traditional Medicine Journal). 2011;16(1):34-42.
14. Lewis DA, Tharib SM, Veitch GB. The anti-inflammatory activity of celery Apium graveolens L.(Fam. Umbelliferae). International Journal of Crude Drug Research. 1985 Jan 1;23(1):27-32.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.