FORMULATION AND EVALUATION OF FAST DISSOLVING ORAL FILM OF ANTI-ALLERGIC DRUG
DOI:
https://doi.org/10.22270/ajprd.v6i3.374Keywords:
Fast dissolving oral film; Loratadine; Plasticizer; Solvent castingAbstract
The aim of present work was the development of fast dissolving oral film of Loratadine to overcome the limitations of current routes of administration, to provide immediate action and increase the patient compliance. To improve the bioavailability of the drug, fast dissolving oral film were formulated using different grades of Hydroxy Propyl Methyl Cellulose(HPMC) and various plasticizers like Polyethylene Glycol(PEG) 400, glycerol, Propylene glycol(PG) by solvent casting method. The formulated films were evaluated for film thickness, surface pH, folding endurance, weight variation, % moisture loss, exvivo permeation study, tensile strength, % elongation, drug content uniformity, in vitro dissolution studies,in vitro disintegration test and in vivo study. The optimized formulation (F9) containing HPMC E5 and glycerol showed minimum disintegration time (10.5 s), highest in vitrodissolution (92.5%) and satisfactory stability. Ex vivo permeation study of optimized formulation showed a drug release of 80.6% within 10 min. The milk induced leucocytosis inrat proved that fast dissolving oral films of Loratadine produced a faster onset of action compared to the conventional tablets. These findings suggest that fast dissolving oral film of Loratadine could be potentially useful for treatment of allergy where quick onset of action is required.
Downloads
References
2. Arya A, Chandra A, Sharma V, Pathak K; Fast dissolving oral films:An innovative drug delivery system and dosage form.Int. J. Chemtech Res. 2010;2(1):576-83.
3. Patil SL, Mahaparale PR, Shivnikar MA, Tiwari SS, Pawar KV, Sane PN. Fast dissolving oral films: An innovative drug delivery system. Int J Res Rev Pharm Appl Sci.2(3):482-96.
4. Tripathi KD. Essentials of Medical Pharmacology. 6th ed. New Delhi: Jaypee; 2008. p.158.
5. Solanki MJ, Subrahmanyam EVS, Shabaraya AR.Development of new analytical Method and its validation for the determination of Loratadine in bulk and marketed formulation .Res J Pharma Biol Chem Sci. 2013;4(4):235-44.
6. USP 34-NF 29. United States: United States Pharmacopeial Convention; 2011. P.122,123, 3333.
7. Jain HK, Patel KH. Development and Validation of UV Spectrophotometric Area Under Curve Method for Estimation of Loratadine in Bulk and Tablet Dosage Form. Am. J. PharmTech Res. 2013;3(4): 492-99.
8. Bayas MSM, Kadam RS, Nalbalwar NN, Jain VKP. UV spectrophotometric estimation of Loratadine in bulk and tablet dosage form using area under curve method. World J. Pharm. Pharm. Sci.2015; 4(5);1822-28.
9. Kumar S, Garg SK, Aseri A. Design, Optimization and in vitro evaluation of Atorvastatin calcium fast dissolving tablet by using solid dispersion technique. World J. Pharm. Pharm. Sci. 2015; 4(3):1217-39.
10. Poluri K, Mulpur E, Puttugunta S.B, Govada K.B.Formulation development and evaluation of novel oral soluble films of Ziprasidone hydrochloride in the treatment of schizophrenia. Int. J. Pharm. Pharm. Sci. 2013;5(2):619-27.
11. Krishna MV, Babitha TE, Farooq U, Krishna VR, Kumar DS.Development of fast dissolving films of Timolol maleate: Role of hydrophillic polymer.Int J Pharma Res Scholars.2014;3(2):830-39.
12. Swami S, Nagendrakumar D, Keshavshetti GG, Mogale P, Swami H. Formulation and evaluation of fast dissolving oral films of Metoprolol succinate. Int J Eng Appl Sci. 2015;6(4):28-38.
13. Sreeja CN, Anoop KR. Design and in vitro evaluation of controlled release Satranidazole subgingival films for periodontitis therapy. Int. J. Pharm. Sci. Rev. Res. 2014; 24(1): 8-14.
14. Karthikeyan D, Sri S, Kumar CS. Development of fast dissolving oral film containing of Rizatriptan benzoate as an anti-migraine medication. Indo Am J Pharma Res.2013; 3(3): 2642 -53.
15. Sri KV, Rohini P, Reddy GK. Montelukast sodium oral thin films: formulation and in vitro evaluation. Asian J. Pharm. Clin. Res. 2012; 5(4):266-70.
16. Bhagat BV, Hapse SA, Darkunde SL, Autade YP.Formulation, development and evaluation of fast dissolving film of an Anti-hypertensive drug. Asian J. Pharm. Technol. Innovation. 2016; 4 (16): 23-30.
17. Pandey GS, Kumar R, Sharma R, Singh Y, Teotia UVS. Development and optimization of oral fast dissolving film of Salbutamol sulphate by design of experiment. Am. J. PharmTech Res. 2013; 3(4): 407- 23.
18. Basu B, Desai P. Design and evaluation of fast dissolving film of Domperidone. Int. Res. J. Pharm. 2012; 3(9): 134- 45.
19. Pandit P, Singh A, Bafna AR, Kadam PV, Patil MJ. Evaluation of anti-asthamatic activity of Curculigo orchioides Gaertn rhizomes. Indian J Pharm Sci 2008;70:330-44.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.