FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS OF IBUPROFEN

Authors

  • M Ramanathan Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam-626130, Sivakasi, Tamil Nadu, India.
  • L Subramanian Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam-626130, Sivakasi, Tamil Nadu, India.
  • Bency Susan varghese Department of Pharmaceutics, Sankaralingam Bhuvaneswari College of Pharmacy, Anaikuttam-626130, Sivakasi, Tamil Nadu, India.

DOI:

https://doi.org/10.22270/ajprd.v6i2.366

Keywords:

Colon targeted, Enteric polymer, FT-IR, Ibuprofen, Matrix and Ulcerative colitis.

Abstract

Ulcerative colitis is a chronic condition of inflammation and ulcers in colon and rectum, the present study aim was to developed Ibuprofen colon targeted matrix tablet for the effective treatment of Ulcerative colitis. Formulation of Ibuprofen matrix tablets was prepare by using different polymers such as Eudragit S 100 and Ethyl cellulose (as carriers) in different ratios. Ibuprofen tablet were prepared by direct compression method. Based on FT-IR study drug and excipient compatibility was checked and confirmed the nil interactions.  The prepared tablets were coated with an enteric polymer and were evaluated for the physicochemical parameters such as hardness, thickness, content uniformity, drug content and in vitro-drug release studies. Among the six formulation F6 showed better drug release 98.51% of Ibuprofen. The stability study was also conducted, the results showed there is no significant changes of drug content and other parameter, which make a clearance of Ibuprofen matrix tablet formulation.

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References

1. Akala E.O, Elekwachi O, Chase V, Johnson H, Lazarre M, Scott K. Organic Redox-initiate, Polymerization Process for the Fabrication of Hydrogels for Colon-specific Drug Delivery. Ind Pharm. 2003; 29(4): p.g 375-386.
2. Akala E.O, Elekwachi O, Chase V, Johnson H, Lazarre M, Scott K. Organic Redox-initiate, Polymerization Process for the Fabrication of Hydrogels for Colon-specific Drug Delivery. Ind Pharm. 2003; 29(4): p.g 375-386.
3. Wood E, Wilson C.G, Hardy J.G. The spreading of foam and solution enemas. International Journal of Pharmacy 1985; 25:p.g 191-197.
4. Singh N, Khanna R.C. Colon targeted drug delivery systems – A Potential Approach. The Pharma journal. Vol. 1 No. 1 2012.
5. QureshAltamash M, MominMunira, RathodSudha, DevAsish, KuteChaitrali. Colon targeted drug delivery system: A review on current approaches. Indian Journal of Pharmaceutical and Biological Research. 2013; 1(4):p.g 130-147.
6. Baumgart DC, Carding SR (2007). "Inflammatory bowel disease: cause and immunobiology." The Lancet. 369 (9573):p.g 1627–40.
7. Shanahan F. Ulcerative colitis. In: Hawkey C.J, Bosch J, Richter J.E, Garcia- Tsao G, Chan F.K.L,Textbook of Clinical Gastroenterology and Hepatology. 2nd edition. Oxford: Wiley- Blackwell; 2012:p.g 355–371.
8. Steele G. Preformulation as an aid to product design in early drug development. In Gibson M, editor. Pharmaceutical Preformulation and Formulation: A Practical guide from Candidate Drug Selection to Commercial Dosage Form.: p.g. 175.
9. Carr.R.L, Evaluation of flow properties of granules, Chem.Eng. 1965, p.g: 72,163- 168.
10. Bulk Density and Tapped Density. In USP 30 NF 25.; 2007. p.g. 643.
11. Powder Flow. In USP 30 NF 25.; 2007. p.g. 688-690.
12. Staniforth J. Powder Flow. In Aulton ME, editor. Pharmaceutics: The Science of Dosage Form Design. 2nd ed.: Churchill Livingstone. p.g. 207.
13. Powder Flow. In USP 30 NF 25.; 2007. p. 688-690. Banker GS, Anderson NR. Tablets. In Lachman L, Lieberman HS, Kanig JL, editors. The Theory and Practice of Industrial Pharmacy. Varghese Publishing House. p.g. 296-301.
14. Friability Test. In Indian Pharmacopoeia.: Government of India; 2010.
15. Weight Variation Test. In USP 30 NF 25; 2007.p.g.731.
16. Stability testing of active substance and pharmaceutical products. WHO Organization, 2006; p.g: 1211, 27:12-30.
17. Hadkar, U.B. Physical Pharmacy. NiraliPrakashan. Pune, 8th edition, 2008, p.g: 20.
18. ICH guideline, European Medicines Agency, 2003: CPMP/ICH/2736/99.

Published

2018-05-28

How to Cite

Ramanathan, M., Subramanian, L., & varghese, B. S. (2018). FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS OF IBUPROFEN. Asian Journal of Pharmaceutical Research and Development, 6(2), 9–19. https://doi.org/10.22270/ajprd.v6i2.366

Issue

VOLUME 6 ISSUE 2 MARCH - APRIL 2018

Section

Research Articles

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