DESIGN AND CHARACTERISATION OF TRANSDERMAL FILM OF GLICLAZIDE FOR THE TYPE-II DIABETES
DOI:
https://doi.org/10.22270/ajprd.v6i2.357Keywords:
Gliclazide, Transdermal film, Eudragit-S100, HPMCk4M and HPMCk15MAbstract
Oral drug delivery system has various drawbacks like poor bioavailability due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and/or frequent dosing, which can be both cost prohibitive and inconvenient. In present study transdermal drug delivery of Gliclazide was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. Matrix type of transdermal films were developed by using polymers Eudragit-S100, HPMCk4M and HPMCk15M.Transdermal films were prepared by employing solvent casting method. Propylene glycol was selected as permeation enhancer and plasticizer. Formulations were prepared with the varying concentrations polymers ranging from F1-F12, and all the formulations were evaluated for various physical parameters, invitro drug release studies by using dialysis membrane. Among all the formulations F5 formulation was found to be best and shown 94.7% drug release in 12 hours. For F5 formulation release kinetics were applied and it was observed that the formulation was following peppas mechanism of drug release. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that they were no interactions.
Downloads
References
2. Arora P, Design, development, physicochemical and in vitro and in vivo evaluation of 14. Transdermal patches containing diclofenacdiethylammonium salt. J Pharm Sci 2002; 91: 2076-2089.
3. Calpena A C, A comparative in vitro study of Transdermal absorption of antiemetics, J Pharm Sci, 1994; 83(1): 29-33.
4. Gwak H S et.al., In-vitro percutaneous absorption of ondansetron hydrochloride from pressure-sensitive adhesive matrices through hairless mouse skin, Arch Pharm Res, 2003; 26 (8): 644-8.
5. Heather A.E. Benson Transdermal Drug Delivery: Penetration Enhancement Techniques Current Drug Delivery, 2005; 2: 23-33.
6. Kunal N Patel, Formulation And Characterization Of Drug In Adhesive Transdermal Patches OfDiclofenac acid. International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491, Vol 4, Issue 1, 2012.
7. MohitSoni, Transdermal Drug Delivery: A Novel Approach to Skin Permeation Journal of Pharmacy Research 2009, 2(8),1184-1190.
8. Prashant M, Evaluation of polymerized rosin for the formulation and development Transdermal drug delivery systems.AAPSPharmscitech. 2005; 6(4):48-53.
9. S. Gao, J. Singh, In vitro Percutaneous Absorption Enhancement of Lipophilic Drug Tamoxifen by Terpenes, J.control. Release 1998; 51:193-199.
10. SahooSunit Kumar et.al., Formulation and Evaluation of Transdermal Patch of Stavudine Dhaka Univ. J. Pharm. Sci. 12(1): 63-69.
Published
How to Cite
Issue
Section
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.