Formulation and Evaluation of Transdermal Patches of Ketoprofin by Using Different Polymers

Abstract

The purpose of this research work was to develop and evaluate matrix-type transdermal patches of Ketoprofen. Employing different ratios of hydrophilic and hydrophobic polymers by solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Seven formulations (consisting of Hydroxypropyl methylcellulose E5 and Ethylcellulose in the ratios of10:0, 0:10, 1:9, 2:8, 3:7, 4:6, 5:5 (F1, F2, F3, F4, F5, F6, F7) were prepared. All formulations carried dimethyl sulfoxide as penetration enhancer and dibutyl phthalate as plasticizer in chloroform and methanol (1:1) as solvent system. The prepared TDDS were evaluated for in vitro release, moisture absorption, moisture loss and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. Patch coded as F1 (HPMC alone) showed maximum release of 95.526 ± 0.982 % in 8 h, where as F2 (EC alone) showed maximum release of 67.078 ± 1.875 % in 24 h and in combination of polymers F7 (5:5) showed maximum release of 86.812 ± 0.262 % in 24 h, emerging to be ideal formulation for Fenoprofen. The results followed Higuchi kinetics (r2), and the mechanism of release was diffusion mediated.