DEVELOPMENT, EVALUATION AND CHARACTERIZATION OF SURFACE SOLID DISPERSION FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF DICLOFENAC

Authors

  • Lende K. Lalita Department of Pharmaceutics, Vjsm’s Vishal Institutes of Pharmaceutical Education and Research, Ale. Pune, Maharashtra, India.
  • DR. S. K. Banerjee Department of Pharmaceutics, Vjsm’s Vishal Institutes of Pharmaceutical Education and Research, Ale. Pune, Maharashtra, India
  • Gadhave M. V. Department of Pharmaceutics, Vjsm’s Vishal Institutes of Pharmaceutical Education and Research, Ale. Pune, Maharashtra, India

Keywords:

Diclofenac, Surface solid dispersion, Solvent evaporation, In vitro dissolution

Abstract

The main objective of the study was to enhance the dissolution of diclofenac, a poorly water soluble drug by surface solid dispersion technique using different carriers and to study the effect of each carrier on the in vitro dissolution profile. The formulations were optimized in the preliminary trials by using various ratios of different carriers like croscarmellose sodium (CCN), crospovidone (CP) and sodium starch glycolate (SSG). Resultant formulations were evaluated using FTIR, X‐ray diffraction, DSC, SEM and in vitro dissolution.

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Published

2013-05-01

How to Cite

Lalita, L. K., Banerjee, D. S. K., & V., G. M. (2013). DEVELOPMENT, EVALUATION AND CHARACTERIZATION OF SURFACE SOLID DISPERSION FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF DICLOFENAC. Asian Journal of Pharmaceutical Research and Development, 1(2), 48–55. Retrieved from https://ajprd.com/index.php/journal/article/view/25

Issue

Volume 1st Issue 3rd May-June 2013

Section

Research Articles

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