Impact of Antidepressant Treatment on Stress Responsivity and Behaviour In Rats Previously Subjected To A Physiological Adversity

Authors

  • Sahil Abbas Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110062, India
  • Fatima Ambrin Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110062, India

Keywords:

Astressin, elevated plus maze, Epinephrine, Hypernatremia, hypothalamo-pituitary-adrenal axis, Norepinephrine, Paroxetine

Abstract

Most of today’s medications are based on the tricyclic antidepressants, which are believed to act by inhibiting the plasma membrane transporters for serotonin and/or noradrenalin. In our study we selected Paroxetine and Astressin, a novel corticotropin releasing factor antagonist, has been found to be particularly potent at inhibiting the hypothalamo-pituitaryadrenal axis. The obsevation of the study was based on impact of antidepressant on the behavioral frame observed in rats. We have chosen hypernatremia for physiological adversity and EPM for psychological stress. We have determined plasma glucose and epinephrine, and brain norepinephrine in our study. Glucose represents a good marker of homeostasis whereas epinephrine and norepinephrine are mediators of allostasis. Both astressin and paroxetine perse showed similar effects on behaviour and stress mediator in our experiments. This indirectly suggests that at least in parts they share common physiology in stress integration. Also, the combination of paroxetine and astressin showed a dichotomy in terms that it has improved the behaviour on EPM

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Published

2015-01-01

How to Cite

Abbas, S., & Ambrin, F. (2015). Impact of Antidepressant Treatment on Stress Responsivity and Behaviour In Rats Previously Subjected To A Physiological Adversity. Asian Journal of Pharmaceutical Research and Development, 3(1), 25–36. Retrieved from https://ajprd.com/index.php/journal/article/view/228

Issue

Section

Research Articles