Impact of Antidepressant Treatment on Stress Responsivity and Behaviour In Rats Previously Subjected To A Physiological Adversity
Keywords:
Astressin, elevated plus maze, Epinephrine, Hypernatremia, hypothalamo-pituitary-adrenal axis, Norepinephrine, ParoxetineAbstract
Most of today’s medications are based on the tricyclic antidepressants, which are believed to act by inhibiting the plasma membrane transporters for serotonin and/or noradrenalin. In our study we selected Paroxetine and Astressin, a novel corticotropin releasing factor antagonist, has been found to be particularly potent at inhibiting the hypothalamo-pituitaryadrenal axis. The obsevation of the study was based on impact of antidepressant on the behavioral frame observed in rats. We have chosen hypernatremia for physiological adversity and EPM for psychological stress. We have determined plasma glucose and epinephrine, and brain norepinephrine in our study. Glucose represents a good marker of homeostasis whereas epinephrine and norepinephrine are mediators of allostasis. Both astressin and paroxetine perse showed similar effects on behaviour and stress mediator in our experiments. This indirectly suggests that at least in parts they share common physiology in stress integration. Also, the combination of paroxetine and astressin showed a dichotomy in terms that it has improved the behaviour on EPM
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