Anti-Cancerous, Anti-Tumour, Anti- Carcinogenic agents - Herbal Medicinal Plants and their immense pharmacological, therapeutics medicinal potent values

Authors

  • Pawan Kumar Sagar Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India) , PCIM & H Campus,  Ghaziabad- 201002, Uttar Pradesh State, India., 
  • Harish Candra 2 Department of Botany and Microbiology, Gurukul Kangri University, Haridwar –Uttarakhand India.
  • Aditya Sagar Department of Botany and Microbiology, Gurukul Kangri University, Haridwar –Uttarakhand India. 
  • Sajwan S Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India) , PCIM & H Campus,  Ghaziabad- 201002, Uttar Pradesh State, India., 
  • R Murugeswaran  National Medicinal Plant Board, Indian Red Cross Society, Annexure Building, Ist & IInd Floor,1, Sansad Marg,  New Delhi-110001, (Ministry of AYUSH, Govt. of India)

DOI:

https://doi.org/10.22270/ajprd.v13i1.1521

Abstract

At present Cancer and Tumor is a common disease and very badly affected to a large number of world population masses. Various modern medical, scientific research and treatment are available to treat Human cancer and tumor now a days. Some of them are very useful and some show many toxic, hazardous and harmful effects upon treated Human cells. At present natural occurring resources substances like herbal, medicinal plant based drugs are trending, discovered of very effected novel drug development bioactive marker compounds for the treatment of every type of illness and diseases. These are non-toxic and give us maximum efficacy and safety. In this review paper, we can studies of Pharmacological, bioactive phytochemical constituents, therapeutic uses, medicinal potent values of herbal Anti-Cancerous, Anti-Tumour’s, Anti-Carcinogenic and  Anti-Cytotoxic 32 species single medicinal plants which are remains a significant challenging task on global levels, explored and available in Asian and southern, northern Himalayan region on the basis of Google search engine databases. These are some 32 species herbal medicinal plants used to treat and cure of various therapeutic illness of public mankind from since ancient time. This review study aims to evaluate, numerous remarkable potent anticancerou’s, antitumor’s, anticarnogenic activities commonly both  In-vitro and In-vivo, due to the presence of Alkaloids, flavonoids, steroidal, glycosides, terpenoids, tannin, phenolic, saponins, lignin’s, proteins and phenolic acids, Anti-cancer’s and Anti-tumor’s major bioactive compounds. However, more research is needed to explore the In-vivo clinical evaluation for their future’s uses, application in treating various ailments for beneficial to public, mankind. Keywords: Anticancer’s, Antitumor’s, Anti-Carcinogenic agent, bioactive phytochemical constituents, Pharmacological, and therapeutic medicinal potential values, electronic Google search engine databases.

 

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Author Biographies

Pawan Kumar Sagar, Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India) , PCIM & H Campus,  Ghaziabad- 201002, Uttar Pradesh State, India., 

Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India) , PCIM & H Campus,  Ghaziabad- 201002, Uttar Pradesh State, India.

Harish Candra, 2 Department of Botany and Microbiology, Gurukul Kangri University, Haridwar –Uttarakhand India.

Department of Botany and Microbiology, Gurukul Kangri University, Haridwar –Uttarakhand India. 

Aditya Sagar, Department of Botany and Microbiology, Gurukul Kangri University, Haridwar –Uttarakhand India. 

Department of Botany and Microbiology, Gurukul Kangri University, Haridwar –Uttarakhand India. 

Sajwan S, Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India) , PCIM & H Campus,  Ghaziabad- 201002, Uttar Pradesh State, India., 

Drug Standardization Research Institute, (Under CCRUM, Ministry of AYUSH., Govt. of India) , PCIM & H Campus,  Ghaziabad- 201002, Uttar Pradesh State, India.

R Murugeswaran,  National Medicinal Plant Board, Indian Red Cross Society, Annexure Building, Ist & IInd Floor,1, Sansad Marg,  New Delhi-110001, (Ministry of AYUSH, Govt. of India)

 National Medicinal Plant Board, Indian Red Cross Society, Annexure Building, Ist & IInd Floor,1, Sansad Marg,  New Delhi-110001, (Ministry of AYUSH, Govt. of India)

References

Anmol, Aggarwal G, Sharma M, Singh R, Shivani, Sharma U. Ethnopharmacologically important highly subsidized Indian medicinal plants: Systematic review on their traditional uses, phytochemistry, pharmacology, quality control, conservation status and future prospective. Journal of Ethnopharmacology. 2024; 320: 117385. DOI:

https://doi.org/10.1016/j.jep.2023.117385

Gonde D P, Bhole B K, Kakad K S. Andrographolide, diterpenoid constituent of Andrographis paniculata: Review on botany, phytochemistry, molecular docking analysis, and pharmacologyAndrographolide, constituant diterpénoïde d’Andrographis paniculata : revue de botanique, de phytochimie, d’analyse d’amarrage moléculaire et de pharmacologie. Journal of Annales Pharmaceutiques Francaises. 2024 ;82(1): 15-43. DOI : https://doi.org/10.1016/j.pharma.2023.10.001

AWARI A, KUMAR M, KAUSHIK D, AMAROWICZ, PROESTOS C, WAHAB R, KHAN M R, TOMASEVIC I, OZ E, OZ F. PROXIMATE ANALYSIS AND TECHNO-FUNCTIONAL PROPERTIES OF BERBERIS ARISTATA ROOT POWDER: IMPLICATIONS FOR FOOD INDUSTRY APPLICATIONS. JOURNAL OF FOODS. 2024; 3(17):1-16; 2802. DOI: HTTPS://DOI.ORG/10.3390/FOODS13172802

Rajput D, Jain D, Kashaw S K, Patil U K. Molecular Docking Studies on Phytoconstituent Isolated from Nyctanthes arbortristis Linn. International Journal of Pharmaceutical Investigation 2024;14(2):399-408. Available DOI: https://doi.org/10.5530/ijpi.14.2.50

Swain N, Sahoo RK, Parameswaran C, Singh NR, Behera B, Samantaray S. Harnessing the Power of Nature: Nyctanthes arbortristis as an Alternative Medicine. The Journal of Phytopharmacology 2024; 13(4):328-333. DOI: https://doi.org/10.31254/phyto.2024.13409

Chabattula SC, Gupta PK, Govarthanan K, Varadaraj S, Rayala SK, Chakraborty D et al. Anti-cancer Activity of Biogenic Nat-ZnO Nanoparticles Synthesized Using Nyctanthes arbor-tristis (Nat) Flower Extract. Appl Biochem Biotechnol. 2024:196:382-399. Available from DOI: https://doi.org/10.1007/s12010-023-04555-1

Kaliyaperumal A K, Dharshini M S, Janani T,Sri V S, Subhasidha R C. Nyctanthes arbortristis Linn. (Night Jasmine): extraction techniques, phytochemical constituents, and biological impacts of extracts and essential oil 2024;10:117;822, Accesses Available from DOI: https://doi.org/10.1186/s43094-024-00694-2

Sagar P K, Sajwan S, et al. Scientific Standardization, Quality Control, Antimicrobial potential, toxicology studies having effective therapeutic uses of (Woodfordia Fruticosa (Linn.) kurz) flowers part. World Journal of Pharmacy and Pharmaceutical Science 2024a;13(6):1301-1323. Available from DOI : http://doi.org/10.20959/wjpps20246-27478

Sagar PK, Khan AS, Sajwan S, Ahmad R. Hindi Research Article-Scientific standardization, quality control screening study of effective therapeutic uses of Dhataki / Dhai Phool / Gul-e-Dhawa (Woodfordia fruticosa (Linn.) Kurz), International Journal of Applied Research 2024b; 10(5): 39-53. Available from DOI: https://doi.org/10.22271/allresearch.2024.v10.i5a.11729

Verma R, Dash S, Ankita, Thakur S, Kumar R, Singh G, Kaur C. Genus Bauhinia (Fabaceae): A review from phytochemistry to pharmacology- Exploring traditional uses and toxicological insights across Asia. Journal of Phytomedicine. 2024;vol-135,156246. DOI. https://doi.org/10.1016/j.phymed.2024.156246

Gupta N, Kondalkar S A, Arya M, Bharthi V,Paul B, Kondalkar A, Meena AK. pharmacognostical, phytochemical, HPTLC and ethano-botanical study of Bauhinia purpurea L. pod. International Journal Pharmaceutical Science and Research. 2024;15(3):889-899. DOI: https://doi.org/10.13040/IJPSR.0975-8232.15(3).889-99

Gudavalli D, Pandey K, Gopal EDE V, Sable D, Ashwini S, Ghagare, Kate AS. Phytochemistry and pharmacological activities of five species of Bauhinia genus: A review. Journal of Fitoterapia. 2024; 105830. DOI: https://doi.org/10.1016/j.fitote.2024.105830

Sagar P K, Khan A S, Kashyap S.Useful medicinal plants having anti-cancerous and anti-tumorous medicinal potential of Withania Somnifera (L.) dunal, Andrographis paniculata (Burm.f.) wall and Glycyrrhiza glabra L. International Journal of Pharmaceutical Science and Research. 2023; 14(7): 3221-3230. DOI: https://doi.org/10.13040/IJPSR.0975-8232.14(7).3221-3230

Regassa H, Sourirajan A, Kumar V, Pandey S, Kumar D, Dev K. Review A Review of Medicinal Plants of the Himalayas with Anti-Proliferative Activity for the Treatment of Various Cancers. Journal of Cancers 2022;14:3898. DOI: https://doi.org/10.3390/cancers14163898

Alam S, Sarker M.M.R, Sultana T.N, Chowdhury M.N.R, Rashid M.A, Chaity N.I, Mohamed I.N. Antidiabetic Phytochemicals from Medicinal Plants: Prospective Candidates for New Drug Discovery and Development. Front. Endocrinol. 2022;13:800714. DOI: https://doi.org/10.3389/fendo.2022.800714

Dalli M, Bekkouch Q, Azizi S E, Azghar A, Gseyra N, Kim B. Nigella sativa L. Phytochemistry and Pharmacological Activities: A Review. Journal of Biomolecules. 2022;12,20: 1-37. DOI:. https://doi.org/10.3390/biom12010020

Khanam S, Prakash A. An overview of medicinal plants as anticancer agents. IP International Journal of Comprehensive and Advanced Pharmacology. 2021;6(2):53-62. DOI: https://doi.org/10.18231/j.ijcaap.2021.010

Choudhary S, Kaurav H, Madhusudan S, Chaudhary G. Daruharidra (Berberis aristata): Review Based upon Its Ayurvedic Properties. Int. J. Res. Appl. Sci. Biotechnol. 2021;8:98-106. DOI: https://doi.org/10.31033/ijrasb.8.2.12

Sagar P K, Sajwan S, Khan AS, Ahmed M W. Useful anti-cancerous & anti-tumorous, immuno-modubulator, medicinal potent asian medicinal plants (Curcuma domestica Valeton or Curcuma longa L., Tinospora cordifolia (Willd.) miers) & Ocimum tanuiflorum L.,Ocimum sanctum L.). International Journal of Multidisciplinary and Educational Research. 2021; 10,8(2): 69-79. DOI:

https://www.researchgate.net/publication/372631355_Useful_Anti-Cancerous_Anti-Tumorous_ Immuno-Modubulator_Medicinal_Potent_Asian_Medicinal_Plants_Curcuma_ Domestica_Valeton_Or_Curcuma_Longa_L_Tinospora_Cordifolia_Willd_Miers _Ocimum_Tanuiflorum_Locimum_

Achyutan, Chandra S, Saklan S. Potent Anti-cancer Medicinal Plants of Garhwal Himalaya. International Journal of Pharmaceutical Research and Applications. 2021;6(5): 683-692. DOI: http://doi.org/10.35629/7781-0605683692

Gnanga M N G, Assanhou A G, Ganfon H, Agbokponto E J, Gbaguidi F A, Virgile AHYI. Annona muricata L. and Annona squamosa L. (Annonaceae): A review of their traditional uses and anticancer activities. Journal of Pharmacognosy and Phytochemistry. 2021; 10(1): 40-51.DOI: https://doi.org/10.22271/phyto.2021.v10.i1a.13287

Chawla K, Mopuri R, Sharma AK, Kumar P. Arnebia euchroma; Chapter-3, Journal of Himalayan Medicinal Plants. 2021;27-41. DOI: https://doi.org/10.1016/B978-0-12-823151-7.00002-7

Jain H, Dhupper R. A Review on Healing Properties of Tinospora Cardifolia (Indian Giloy). Inter. Journal for Res. App. Sci. Eng. Tech. 2021; 9(5):1114-1118.

Aizad S, Zubairi S I, Yahaya B H, Lazim A M. Centella asiatica Extract Potentiates Anticancer Activity in an Improved 3-D PHBV-Composite-CMC A549 Lung Cancer Microenvironment Scaffold. Arab. Journal of Sci. Eng. 2021; 46:5313-5325. [CrossRef]

Wang Y, Liu Y, Du X, Ma H, Yao J. The Anti-Cancer Mechanisms of Berberine: A Review. Journal of Cancer Manag. Res. 2020;12:695-702. DOI: https://doi.org/10.2147/CMAR.S242329

Kumar A, Shashni S, Kumar P, Pant D, Singh A, Verma R.K. Phytochemical constituents, distributions and traditional usages of Arnebia euchroma: A review. J. Ethnopharmacol. 2021; 271: 113896. [CrossRef] [PubMed]

Parekh S, Soni A. Nyctanthes arbor-tristis: Comprehensive review on its pharmacological, antioxidant, and anticancer activities. Journal of Applied Biology & Biotechnology 2020; 8(01): 95-104. Available from DOI: https://doi.org/10.7324/JABB.2020.80116

Batiha G S. Alkazmi L M, Wasef L G, Beshbishy A M, Nadwa E H, Rashwan E K. Syzygium aromaticum L. (Myrtaceae): Traditional uses, bioactive chemical constituents, pharmacological and toxicological activities. Biomolecules 2020a; 10, 202. [CrossRef]

Batiha G E S, Beshbishy A M, Mleeh A E ,Daim M M A ,Prasad D. Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae). Journal of Biomolecules. 2020b;10,352: 1-19. DOI: http://doi.org/10.3390/biom10030352

Sagar P K, Meena R P, Ahmad W A, Sajwan K. 2020. Useful Anti-Cancerous & Anti-tumorous Asian medicinal Plants (Taxus baccata L. or Taxus baccata Thunb., Catharanthus roseus (L.) G. Don, Annona muricata (L.).International Journal of Traditional and Complementary Medicine. 2020; 5(22): 1-12.

Boulos J C, Rahama M, Hegazy M F, Efferth T. Shikonin derivatives for cancer prevention and therapy. Canc. Lett. 2019; 459 (10): 248e267.

Harmila K J, Monisha S M, Beevi AA, Deebarathi V. Antibacterial, antioxidant, anticancer effects and GCMS analysis of Berberis aristata. Biomedicine 2020; 40: 286-293.

Sood H, Kumar Y, Gupta VK, et al. Scientific validation of the antimicrobial and antiproliferative potential of Berberis aristata DC. root its phytoconstituents and their biosafety. Journal of AMB Expr. 2019;9:143. DOI: https://doi.org/10.1186/s13568-019-0868-4

Al-Ghazzawi AM. Anti-cancer activity of new benzyl isoquinoline alkaloid from Saudi plant Annona squamosa. Journal of BMC Chem. 2019; 13: 1-6. [CrossRef]

Kasai H, Yamane Y, Ikegami-kagami-kawai M, and Sudo H. Analysis of compounds of Curecuma Rhizome using mass spectrometery and investigation of the Antioxidant Activity of Rhizomes Extracts, Journal of Medicinal and Aromatic plants (Los Angeles) 2019;,8(4),336:1-7.

Akter J, Hossain M A, Takara K, Islam M Z, Hou D X. Antioxidant activity of different species and varieties of turmeric (Curcuma spp): Isolation of active compounds, Journal of Comp Biochem Physiol C Toxicol Pharmacol 2019;215: 9-17.

Jagetia G C, Magri H. Anticancer activity of Giloe, Tinospora Cardifolia (Willd.), Miers Ex Hook F and Thoms, International Journal of Complementary & Alternative medicine 2019; 12 (2) :79-85.

Wang Y, Zhu Y, Xiao L, Ge,L, Wu X, Wu W, Wan H, Zhang K, Li J, Zhou B, Tian J, Zeng X. Meroterpenoids isolated from Arnebia euchroma (Royle) Johnst. and their cytotoxic activity in human hepatocellular carcinoma cells. Journal of Fitoterapia. 2018; 131, 236e244. https://doi.org/10.1016/j.fitote.2018.11.005

Firdous Q,Bhat M F,Hussain M. Ethnopharmacology, phytochemistry and biological activity of Inula Racemosa Hook. f: a review. International Journal of Research Auyrveda Pharma. 2018;9(1):95-102. DOI: http://dx.doi.org/10.7897/2277-4343.09120

Shourie A, Chandwani A, Singh S, Rawal A, Vijayalakshmi U. Anti-cancerous potential of Medicinal Plants- A review. World Journal of Pharmaceutical Research. 2017; 6(6): 462-483. DOI : https://doi.org/10.20959/wjpr20176-8624

Moga M, Balan A, Anastasiu C, Dimienescu O, Neculoiu C, Gavris ˘ , C, et al. An Overview on the Anticancer Activity of Azadirachta indica (Neem) in Gynecological Cancers. Int. Journal of Mol. Sci. 2018;19(12):3898. DOI: http://doi.org/10.3390/ijms19123898

Siegel R L, Miler K D. Jemal, A. Cancer Statistics, CA Cancer Journal of Clinic, 2018; 68(1) :7-30.

Onloma C, Yangb Y , Aisab HA, Woranuchc N, Phrompittayaratd W, Putalune W, Ingkaninana K. Preparative and Rapid Purification of Saponins from Asparagus racemosus Root by High Performance Centrifugal Partition Chromatography. Journal of Natural Products Communication. 2017;12(2):241-244. DOI:

https://journals.sagepub.com/doi/epdf/10.1177/1934578X1701200225

Chander V, Aswal JS, Dobhal R,Uniyal DP. A review on Pharmacological potential of Berberine; an active component of Himalayan Berberis aristata. The Journal of Phytopharmacology. 2017;6(1):53-58. DOI:

https://www.phytopharmajournal.com/Vol6_Issue1_08.pdf

Promila, Singh S,Devi P. Pharmacological potential of Tinospora cordifolia (Willd.) Miers ex hook. & Thoms. (Giloy): A review. Journal of Pharmacognosy and Phytochemistry. 2017; 6(6): 1644-1647. DOI: https://www.phytojournal.com/archives/2017/vol6issue6/PartW/6-6-239-262.pdf

Amin F. Majdalawieh* , Muneera W. Fayyad. Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive. Journal of Ayurveda and Integrative Medicine. 2016; 7:173-180. DOI: https://doi.org/10.1016/j.jaim.2016.07.004

Jain S, Dwivedi J, Jain P K ,Satpathy S, Patra A. Medicinal Plants for Treatment of Cancer: A Brief Review. Journal of Pharmacognosy. 2016; 8(2): 87-108.

Shakya AK. Medical plants: Future source of new drugs. International Journal of Herbal Medicine. 2016; 4(4): 59-64.

Sukhdev S, Sharma B, Kanwar S S, Kumar A. Lead phytochemical for anticancer Drug Development. International Journal of Frontiers in plant. 2016; Science,7, Article-1667:1-13. DOI: https://doi.org/10:3389/fpls.2016.01667

Alzohairy M A. Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment. Journal of Evidence-Based Complementary and Alternative Medicine. 2016; 2016:1-11;7382506. DOI: http://dx.doi.org/10.1155/2016/7382506

Ayeka PA, Bian Y, Mwitari PG, Chu X, Zhang Y,Uzayisenga R, Otachi EO. Immunomodulatory and anticancer potential of Gancao (Glycyrrhiza uralensis Fisch.) polysaccharides by CT-26 colon carcinoma cell growth inhibition and cytokine IL-7 upregulation In-vitro, Journal of Medicine. 2016; 16: 206-216.

Pandian N and Chidambaram S: Antimicrobial, Cytoxicity and Cancer activity of Silver nanoparticles from Glycyrrhiza glabra, International Journal of Pharmaceutical Science and Research. 2016; 16: 1633-1641.

Iwan Sahrial Hamid, Ngakan Made Rai Widjaja, Ratna Damayanti. Anticancer Activity of Centella asiatica Leaves Extract in Benzo(a) pyrene-Induced Mice. International Journal of Pharmacognosy and Phytochemical Research. 2016; 8(1):80-84.

Ahmad R, Fatima N, Srivastava AN, Khan MA. Anticancer Potential of Medicinal Plants Withania Somnifera, Tinospora Cordifolia and Curcuma Longa: A Review. World Res Journal of Med. Aromatic Plants. 2015;3(1):47-56.

Upadhyay A K , Chacko A R, Gandhimathi A. Genome sequencing of herb Tulsi (Ocimum tenuiflorum) unravels key genes behind its strong medicinal properties. Journal of BMC Plant Biology. 2015;15; 212: 01-20. DOI: https://doi.org/10.1186/s12870-015-0562-x

He Q, Liu X C, Sun R Q, Deng Z W, Du S S, Liu Z L. Mosquito larvicidal constituents from the ethanolextract of Inula racemosa Hook. f. Roots against Aedesalbopictus. Journal of Chemistry 2014,2014.45.

Rahmani A. H., Alzohairy M. A., Khan M. A., Aly S. M. Therapeutic implications of black seed and its constituent thymoquinone in the prevention of cancer through inactivation and activation of molecular pathways. Evidence-Based Complementary and Alternative Medicine. 2014;2014:13. DOI: http://doi.org/10.1155/2014/724658.724658

Juyal D, Thawani V, Thaledi S, Joshi M. Ethnomedical properties of Taxus wallichiana zucc. (Himalayan yew). Journal of Tradit. Compl. Med. 2014; 4:159-161. [CrossRef]

Jung I L. Soluble extract from Moringa oleifera leaves with a new anticancer activity. Journal of PLoS ONE. 2014, 9, e95492. [CrossRef]

Gurav S, Gurav N. A Comprehensive review: Bergenia ligulata Wall- A controversial clinical candidate. Int. Journal of Pharm. Sci. Rev. Res. 2014; 5:1630-1642.

Alam S, Katiyar D, Goel R, Vats A, Mittal A. Role of herbals in cancer management. The Journal of Phytopharmacology. 2013; 2(6): 46-51.

Ma Y-Y, Zhao D-G, Gao K. Structural investigationand biological activity of sesquiterpene lactones from thetraditional Chinese herb Inula racemosa. Journal of naturalproducts 2013,76 (4), 564-570.43.

Rasul A, Khan M, Ali M, Li J,Li X X. Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone. The Scientific World Journal. 2013; 248532:1-9. DOI:

http://dx.doi.org/10.1155/2013/248532

Prakash O. Anticancer Potential of Plants and Natural Products: A Review. American Journal of Pharmaceutical Science 2013;1(6):104-15.

Sadooghi SD, Nezhad-Shahrokh-Abadi K, Balanezhad S Z, Baharara J. Investigating the cytotoxic effects of ethanolic extract of Ferula asafoetida resin on HepG2 cell line. Journal of Feyz. 2013;17:323-330.

Singh P, Andola C, Harish, Rawat MSM, Joshi G and Zafer HS. Himalayan Plants as a source of Anti-Cancer Agents: A Review. Journal of The Natural Products. 2013; 3(4): 296-308.

Umadevi M , Kumar K P S ,Bhowmik D, Duraivel S. Traditionally Used Anticancer Herbs In India. Journal of Medicinal Plants Studies. 2013;1(1): 56-74.

Gnanasekaran D, Reddy C, Jaiprakash B, Narayanan N, Kiran Y, Elizabeth H Ad. aptogenic activity of siddha medicinal plant Inula racemosa. Int. Journal Biol. Pharm. Allied Sci. 2012,1 (6), 870-880

Mitra S K, Prakash N S, Sundaram, R. Shatavarins (containing Shatavarin IV) with anticancer activity from the roots of Asparagus racemosus. Indian Journal of Pharmacol. 2012, 44, 732. [PubMed]

Potdar D, Hirwani R R, Dhulap S. Phyto-chemical and pharmacological applications of Berberis aristata. Journal of Fitoterapia. 2012;83(5): 817-830. DOI:

https://doi.org/10.1016/j.fitote.2012.04.012

Agarwal N, Majee C, Chakraborthy G. Natural herbs as anticancer drugs. International Journal of Pharm. Tech. Res. 2012;4:1142-53.

Widowati W, Mozef T; Risdian C; Ratnawati, H, Tjahjani S, Sandra F. The comparison of antioxidative and proliferation inhibitor properties of Piper betle L., Catharanthus roseus [L.] G. Don, Dendrophtoe petandra L., Curcuma mangga Val. extracts on T47D cancer cell line. Int. Res. Journal of Biochem. Bioinform. 2011; 1: 22-28.

Ghosh T, Maity T K, Singh J. Evaluation of antitumor activity of stigmasterol, a constituent isolated from Bacopa monnieri Linn aerial parts against Ehrlich Ascites Carcinoma in mice. Orient. Pharm. Exp. Med. 2011; 11:41-49. [CrossRef]

Bisht V K, Negi J S, Bhandari A K, Sundriyal R C. Anti cancerous Plants of Uttarakhand Himalaya: A Review. International Journal of Cancer Research. 2011; 7(3): 192- 208. DOI: http://doi.org/10,3923/ijcr2011.192.208

Zhang T, Xiao W, Gong T, Yang Y, Chen R Y, Yu D Q. Two new eudesmanolides from Inula racemosa.Journal of Asian natural products research 2010,12 (9),788-792.44.

Patel P R; Raval BP, Karanth HA, Patel VR. Potent antitumor activity of Rubia cordifolia. Int. Journal of Phytomedicine 2010; 2: 44-46.

Khan M A , Chen H C, Tania M, Zhang D Z. Anticancer activities of Nigella Sativa (Black cumin). African Journal of Traditional Complementary and Alternative Medicine. 2011;8(S): 226-232. DOI: https://doi.org/10.4314/ajtcam.v8i5S.10

GOHIL K J, PATEL JA, GAHHAR AK. PHARMACOLOGICAL REVIEW ON CENTELLA ASIATICA: A POTENTIAL HERBAL CURE-ALL. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2010;72(5): 546-556. DOI: HTTP://DX.DOI.ORG/10.4103/0250-474X.78519

Gadgoli C, Shelke S. Crocetin from the tubular calyx of Nyctanthes arboe-tristis. Journal of Natural Product Research. 2010;24(17):1610-1615. DOI:

https://doi.org/10.1080/14786411003754363

Xiong W, Luo G, Zhou L, Zeng Y, Yang W. In vitro and in vivo antitumor effects of acetyl shikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures. Chin.2019; Journal of Med. 2009; 4, 14.

Aggarwal B B, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P. Potential of spice-derived phytochemicals for cancer prevention. Journal of Planta Med. 2008;74: 1560-1569.

Al-Ali A, Alkhawajah A A, Randhawa M A, Shaikh, N A. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. Journal of Ayub. Med. Coll. Abbottabad. 2008;20: 252-257.

Das P K, Goswami S, Chinniah A,Panda N, Banerjee S, Sahu N P, Achari B. Woodfordia fruticosa: Traditional uses and recent findings. Journal of Ethnopharmacol. 2007; 110: 189-199. [CrossRef] [PubMed]

Madhusudan S, Middleton MR. The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer. Cancer Treat Rev. 2005;31(8):603–17. DOI: https://doi.org/10.1016/j.ctrv.2005.09.006

Balunas MJ, Kinghorn AD. Drug discovery from medicinal plants. Journal of Life Science.2005 ;78 (5):431-441. DOI: https://doi.org/10.1016/j.lfs.2005.09.012

Singh S S, Pandey SC, Srivastava S, Gupta VS, Patro B, Ghosh AC, et al. Chemistry and medicinal properties of Tinospora cordifolia (Guduchi). Industrial Journal of Pharmacol. 2003;35:83-91.

Abdullaev FI. Plant-derived agents against cancer. In: Gupta S, editor. Pharmacology and therapeutics in the new millennium. New Delhi, India: Narosa publishing house; 2001: 345-54.

Sumner J. The natural history of medicinal plants. Timber Press; 2000.

Babu T D, Kuttan G, Padikkala J. Cytotoxic and anti-tumor properties of certain taxa of Umbelliferae with special reference to Centella asiatica (L.) Urban. J Ethnopharmacol. 1995;48:50-57. DOI: http://dx.doi.org/10.1016/0378-8741(95)01284-k

Kumar E P, Elshurafa AA, Elango K, Subburaju T, Suresh B. Anti–Tumour Effect of Berberis Asiatica Roxb. Ex. Dc. On Dalton’s Lymphoma Ascite. Anc. Sci. Life 1998; 17:290

Kuttan R, Bhanumathy P, Nirmala K, George M C. Potential anticancer activity of turmeric (Curcuma longa). Journal of Cancer Lett. 1985; 29: 197-202. [CrossRef]

Published

2025-02-15

How to Cite

Sagar, P. K., Candra, H., Sagar, A., S, S., & Murugeswaran, R. (2025). Anti-Cancerous, Anti-Tumour, Anti- Carcinogenic agents - Herbal Medicinal Plants and their immense pharmacological, therapeutics medicinal potent values. Asian Journal of Pharmaceutical Research and Development, 13(1), 238–258. https://doi.org/10.22270/ajprd.v13i1.1521