Current Trends in Alkaloid Research: From Natural Sources to Synthetic Pathways
DOI:
https://doi.org/10.22270/ajprd.v12i5.1469Abstract
Alkaloid is a large family of the diverse natural compounds that are provided with nitrogen atoms. Primarily derived from vegetation, these substances have a great many actions, opening up their applications in medicine, agriculture, and industry. This review is a complete description of alkaloids; starting from the sorting, the biosynthesis, and pharmacological activities, it covers all the aspects. The epitome of their therapeutic uses, such as pain relievers, heart rate stimulants, antimalarial drugs, anticancer drugs, and antibiotics, will be made. The authors present recent frontiers on Biotechnological approaches, the new discovery of alkaloids and the development of environmentally friendly production techniques. This publication is ended with the statement that in the places of personalized medicine, nanotechnology, and synthetic biology, especially alkaloids are key players in creating more effective drugs to different diseases.
Downloads
References
1. Dewick, P. M. (2009). Medicinal Natural Products: A Biosynthetic Approach. John Wiley & Sons.
Cordell, G. A. (2012). Introduction to Alkaloids: A Biogenetic Approach. John Wiley & Sons.
Wink, M. (2010). Biochemistry of Plant Secondary Metabolism. Wiley-Blackwell.
Pelletier, S. W. (2013). Alkaloids: Chemical and Biological Perspectives, Volume 13. Pergamon Press.
Raffauf, R. F. (2016). Alkaloids of Plants: A Review of Chemical Literature, 1930-1960. Springer Science & Business Media.
Padmini, E., & Rekha, K. Alkaloids as Potential Anticancer Agents: A Review. Pharmacognosy Reviews, 2018;12(23):145-158.
Pan, L., Chai, H., Kinghorn, A. D. (2010). The Continuing Search for Anticancer Agents from Higher Plants. CRC Press.
Facchini, P. J. Alkaloid Biosynthesis in Plants: Biochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications. Annual Review of Plant Physiology and Plant Molecular Biology, 2001; 52:29-66.
Hagel, J. M., & Facchini, P. J. Plant Alkaloid Biosynthesis: Development and Application of Transcriptomics Approaches. Phytochemistry Reviews, 2013; 12(3):473-491.
Talreja, S., & Tiwari, S. Supramolecular chemistry: unveiling the fascinating world of non-covalent interactions and complex assemblies. J. Pharm. Pharmacol. Res, 2023; 7:133-139
Ma, X., & Gang, D. R. The End of Opium Poppy Prohibition; China Plans for Exportation of Narcotic Alkaloids. Phytochemistry,2004; 65(24):3173-3185.
Oberlies, N. H., & Kroll, D. J. Camptothecin and Taxol: Historic Achievements in Natural Products Research. Journal of Natural Products, 2004; 67(2):129-135.
Lee, C. W., & Yang, J. W. Recent Advances in the Genetic Engineering of Plants to Enhance the Production of Alkaloids. Biotechnology Advances, 2014; 32(7):1178-1186.
Berkov, S., Zayed, R., & Doncheva, T. Alkaloids in Stem and Leaf of Hyoscyamus reticulatus. Zeitschrift für Naturforschung C, 2011; 66(11-12):481-486.
Talreja, S., & Tiwari, S. From One to Millions: The Revolution of Combinatorial Chemistry. Journal of Analytical Techniques and Research, 2024; 6(2):37-42
Böttger, A., Vothknecht, U. C., Bolle, C., & Wolf, A. Plant Secondary Metabolites and Their General Function in Plants. Lessons on Caffeine, Cocaine, and Morphine in Nature. Journal of Plant Physiology, 2018; 229:172-180.
Published
How to Cite
Issue
Section
Copyright (c) 2024 Shreya Talreja, Dr. Shashank Tiwari
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
. 