Unlocking the Potential of Niosomes: A Comprehensive Review
DOI:
https://doi.org/10.22270/ajprd.v11i3.1421Abstract
Niosomes are vesicular systems that are similar to liposomes and are obtained by hydrating synthetic nonionic surfactants, with or without incorporating cholesterol or their lipids. They can be used as carriers for amphiphilic and lipophilic drugs and are biodegradable, biocompatible, non-immunogenic, and flexible in their structural characterization. Niosomes have been widely evaluated for controlled release and targeted delivery for the treatment of cancer, viral infections, and other microbial diseases. They can entrap both hydrophilic and lipophilic drugs and prolong the circulation of the entrapped drug in the body. By encapsulating drugs in a vesicular system, the existence of the drug in the systemic circulation can be extended, and penetration into target tissue can be enhanced, reducing toxicity if selective uptake can be achieved. This review article focuses on the advantages, disadvantages, types, preparation methods, factors affecting, characterizations and applications of niosomes.
Downloads
References
Singh D, Upadhyay P. Niosomes: a novel vesicular approach. World J Pharmacy Pharm Sci. 2016; 5(12):1586-92.
Gadhiya P, Shukla S, Modi D, Bharadia P. Niosomes in targeted drug delivery – a review. Int J Pharm Res Scho. 2012; 1(2):59-72.
Gurjar P, Naik N, Chouksey S. Niosome: a promising pharmaceutical drug delivery. Int J Pharm Analysis. 2014; 2(5):425-31.
Verma KN, Rai AK, Gulzar A, Singh AP. Niosomes:An approach to current drug delivery-a review. Int J Adv Pharma. 2017; 06 (02):41-8.
Singh S. Niosomes: a role in targeted drug delivery system. Int J Pharm Sci Res. 2013; 4(2):550-57.
Gandhi A, Sen SO, Paul A. Current trends in niosome as vesicular drug delivery system. Asian J Pharm Life Sci. 2012; 2(2):339-53.
Kaur D, Kumar S. Niosomes: present scenario and future aspects. Journal of drug delivery and therapeutics. 2018 Sep 6;8(5):35-43.
Blazek–Welsh AI, Rhodes DG. SEM imaging predicts quality of niosomes from maltodextrin-based proniosomes. Pharmaceutical research. 2001 May;18:656-61.
Baillie AJ, Florence AT, Hume LR, Muirhead GT, Rogerson A. The preparation and properties of niosomes—non‐ionic surfactant vesicles. Journal of pharmacy and pharmacology. 1985 Dec;37(12):863-8.
Blazek-welsh ai, rhodes dg: maltodextrin-based proniosomes. Aaps pharmsci [electronic resource] 2001;3:e1
Arunothayanun p, turton ja, uchegbu if, florence at, preparation and in vitro in vivo evaluation of luteinizing hormone releasing hormone (lhrh)-loaded polyhedral and. Spherical tubular niosomes.journal of pharmaceutical sciences 1999;88:34-38.
Gadhiya p et al., niosomes in targeted drug delivery – a review, international journal for pharmaceutical research scholars (ijprs), v-1, i-2, 2012, 59-72
Sonule M, Gandhi M, Paralkar S, Dabhade D, Pagar S. Niosomes: novel drug delivery system. Int J Pure App Bio Sci. 2014; 2(2):267-74.
Parmar RP, Parmar RB. Conceptual aspects of vesicular drug delivery system with special reference to niosome. Asian J Pharm Tech. 2013; 3(2):52-59.
Chandu VP, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G. Niosomes: a novel drug delivery system. Int J novel trends Pharm Sci. 2012; 2(1):25-31.
Maurya R, Pathak K, Saxena P, Tiwari J. A review on novel drug delivery system – niosomes. Asian J Pharm Res Dev. 2013; 1(4):51-59.
Makeshwar K, Wasankar S. Niosomes: a novel drug delivery system. Asian J. Pharm. Res. 2013; 3: 16-20.
Sankhyan A, Pawar P. Recent Trends in Niosome as Vesicular Drug Delivery System. Journal of Applied Pharmaceutical Science. 2012; 2: 20-32.
Gurjar P. Niosome: A Promising Pharmaceutical Drug Delivery. Int. J. Pharm Anal. 2014; 2: 425-431
Gayatri Devi S., Venkatesh P. and Udupa N. Niosomal sumatriptan succinate for nasaladministration. Int. J.Pharm. Sci. 62(6), 2000; 479-481.
Jaydeep D Yadav et al, NIOSOMES: A REVIEW, Journal of Pharmacy Research 2011,4(3),632-636
Yoshioka T., Stermberg B., Florence A.T., Preparation and properties of vesicles (niosomes) of sorbitan monoesters (Span 20, 40, 60, and 80) and a sorbitan triester (Span 85). Int. J Pharm. 1994; 105: 1-6.
Dubey Subodh et al, Niosomes: The ultimate drug carrier Drug Invention Today 2010,2(1),72-77
Parthasarathi, G, Udupa, N., Umadevi P., Pillai G.K., Formulation and in vitro evaluation of vincristine encapsulated Niosomes. Journal of Drug Targeting. 1994; 2: 173–82.
Khandare J.N., Madhavi G. and Tamhankar B.M. Niosomesnovel drug delivery system. The Eastern Pharmacist. 37: 1994; 61-64.
Malhotra M. and Jain N.K. Niosomes as Drug Carriers. Indian Drugs, 31(3): 1994; 81-86.
Junyaprasert VB, Teeranachaideekul V, Supaperm T. Effect of Charged and Non-ionic Membrane Additives on Physicochemical Properties and Stability of Niosomes. AAPS PharmSciTech. 2008; 9(3): 851-859.
Arunothayanun P. et al. The effect of processing variables on the physical characteristics of nonionic surfactant vesicles (niosomes) formed from hexadecyl diglycerol ether. Int. J. Pharm., 2000, 201.
Uchegbu FI and Vyas PS. Non-ionic surfactant based vesicles (niosomes) in drug delivery. Int.J. Pharm.172, 1998, 33.
Yoshida H., Lehr, C.M., Kok W., Junginger H.E., Verhoef J.C., Bouwistra J.A,. Niosomes for oral delivery of peptide drugs. J.Control Rel.1992;21: 1458153.
Satturwar, P.M., Fulzele, S.V., Nande, V.S., Khandare, J.N., Formulation and evaluation of ketoconazole Niosomes. Indian J.Pharm, 2002; 64(2): 1558158.
Vyas S.P., Khar R, K., Niosomes Targeted and Controlled Drug delivery, 2008; 249 – 279.
M and Perrier D; Pharmacokinetics, second edition, New York, Marcel Dekker, Inc., 1982; 1278134.
Namdeo, A., Jain, N.K., Niosomal delivery of 58fluorouracil. J.Microencapsul. 1999; 16 (6): 731 – 740.
Bhaskaran S., Panigrahi L., Formulation and Evaluation of Niosomes using Different Nonionic Surfactant. Ind J Pharm Sci. 2002, 63: 186
Balasubramanian A., Formulation and In8Vivo Evaluation of Niosome Encapsulated Daunorubicin Hydrochloride. Drug Dev and Ind.Pharm.2002, 3(2): 1181884.
Mayer L.D., Bally M.B., Hope M.J., Cullis P.R., Biochem Biophys. Acta.1985, 816: 2948302.
Raja Naresh R.A., Chandrashekhar G., Pillai G.K., Udupa N., Antiinflammatory activity of Niosome encapsulated diclofenacsodium with Tween885 in Arthitic rats. Ind.J.Pharmacol. 1994, 26: 4648.
Chauhan S., Luorence M.J., The preparation of polyoxyethylene containing non8ionic surfactant. Vesicles. J. Pharm. Pharmacol. 1989,41: 1-6.
Sonule M, Gandhi M, Paralkar S, Dabhade D, Pagar S. Niosomes: novel drug delivery system. Int J Pure App Bio Sci. 2014; 2(2):267-74.
Chandu VP, Arunachalam A, Jeganath S, Yamini K, Tharangini K, Chaitanya G. Niosomes: a novel drug delivery system. Int J novel trends Pharm Sci. 2012; 2(1):25-31.
Vadlamudi C H, Sevukarajan M. Niosomal drug delivery system-a review. Indo Am J Pharm Res. 2012; 2(9).
Kumar Abhinav, Pal Jagendar Lal, Jaiswal Amit, Singh Vishwanabhan. Review of niosomes as novel drug delivery system. Int Res J Pharm. 2011; 2(5): 61-65.
Prabagar Balakrishnan, Srinivasan Shanmugam, Won Seok Lee, Won Mo Lee, Jong Oh Kim, Dong Hoon Oh, Dae-Duk Kim, Jung Sun Kimc, Bong Kyu Yoo, Han-Gon Choi, Jong SooWoo, Chul Soon Yong.
Formulation and in vitro assessment of minoxidil niosomes for enhanced skin delivery. Int J Pharm. 2009; 377: 1–8.
Manosroi A. Characterization of Vesicles Prepared with Various Nonionic Surfactants mixed with Cholesterol. Colloids surf. Biointerfaces. 2003; 30: 129-138
Kreuter J. Colloidal Drug Delivery System of Niosome, Dekker series, Dekker publication.66:73.
Muzzalupo R, Trombino S, Iemma F, Puoci F, Mesa CL, Picci N. Preparation and characterization of bolaform surfactant vesicles. Colloids Surf B. Biointerfaces. 2005; 46(2): 78–83.
Muller RH, Radtke M, Wissing SA. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv Drug Deliv. 2002; 54: 131-155.
Arunothayanun P, Bernard MS, Craig DM, Uchegbu IF, Florence AT. The effect of processing variables on the physical characteristics of non-ionic surfactant vesicles (niosomes) formed from a hexadecyl diglycerol ether. Int J Pharm. 2000; 201: 7–14.
Makeshwar K, Wasankar S. Niosomes: a novel drug delivery system. Asian J. Pharm. Res. 2013; 3: 16-20.
Tangriet P. Niosomes: Formulation and Evaluation. International Journal of Biopharmaceutics. 2011; 2: 47-53.
Jindal K. Niosomes as a Potntial Carrier System: A Review. IJPCBS. 2015; 5: 947-959.
Kaur H, Dhiman S, Arora S. Niosomes: A novel drug delivery system. Int. J. Pharm. Sci. Rev. Res. 2012; 15: 113-120.
Gandhi A, Sen S, Paul A. Current Trends in Niosomes As vesicular drug delivery system. Asian Journal of Pharmacy and Life Science. 2012; 2: 339- 353.
Suzuki K, Sokan K. The Application of Liposomes to Cosmetics. Cosmetic and Toiletries. 1990; 105: 65-78.
Tabbakhian M, Tavakoli N, Jaafari M, Daneshamouz S. Enhancement of follicular delivery of finasteride by liposomes and niosomes. Int. J. Pharm. 2006; 323: 1-10.
Sita VG, Jadhav D, Vavia P. Niosomes for nose-to-brain delivery of bromocriptine: Formulation development, efficacy evaluation and toxicity profiling. Journal of Drug Delivery Science and Technology. 2020 Aug 1;58:101791
Published
How to Cite
Issue
Section
Copyright (c) 2024 Punam V. Ritthe, Dr. Ajay Fugate, Dr. Sameer Shafi, Muktai N. Rudrurkar, Anis J. Kazi, Sneha R. Patil, Rohini U. Sante, Imran Shaikh.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.