Formulation Development and Evaluation of Nanofibers Containing Antifungal Drug using Electrospining Technique for the Treatment of Oral Candidacies

Authors

  • Aboli A. Mirgane Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India
  • Smita P Borkar Assistant Professor, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India
  • Snehal M Shinde Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India
  • Priti U More Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

DOI:

https://doi.org/10.22270/ajprd.v11i3.1392

Abstract

Oral Candidiasis is common disease caused due to overgrowth of Candida albicans. To treat this type of infection different dosage forms are marketed. The purpose behind this research is to provide knowledge about nanofibers as a novel drug delivery for the treatment of oral candidiasis. For the formulation of nanofibers electrospinning technique was used. To determine the effectiveness of nanofiber drug delivery evaluation was done.

 

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Author Biographies

Aboli A. Mirgane, Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

Smita P Borkar, Assistant Professor, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

Assistant Professor, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

Snehal M Shinde, Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

Priti U More , Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

Research Scholar, Department of Pharmaceutics, Arvind Gavali College of Pharmacy, Jaitapur, Satara, Maharastra, India

References

Nagarani B, Ashwinkumar K, Parepalli S. A review on oral mucosal cavity and sublingual formulations. International Journal of Innovative Pharmaceutical Sciences and Research. 2014; 2(8): 1896–1918.

Aghera NJ, Shah SD, Vadalia KR. Formulation and evaluation of sublingual tablets of losartan potassium. Asian Pacific Journal of Tropical Disease. 2012; 2(1): S130–S135.

Patel NK, Pancholi S. An overview on: sublingual route for systemic drug delivery. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2012; 3(2): 913–923.

Anahita Rohani Shirvan et.al. Fabrication of multifunctional mucoadhesive buccal patch for drug delivery applications. Journal of Biomaterials. 2021; 1(3):1–17.

Tonglairoum et.al., Fast acting clotrimazole composited PVP/HPβCD nanofiber for oral candidiasis application. Springer Science.2014; 31(8):1-14.

Epstein J. Oral Candidiasis: Pathogenesis and Host Defense. The University of Chicago. 1984; 6(1):96-97.

Radha Madhavi B. et.al., Buccal Film Drug Delivery System-An Innovative and Emerging Technology. Journal of Molecular Pharmaceutics & Organic Process Research.2013;1(3):2-2

ames S., Encyclopedia of Pharmaceutical technology. 1: 2664-73.

Michael j. Rathbone, Ian W. Kellaway, Gilles Pochel, and D.Duchene, Modified released drug delivery, Copyright by Marcel Dekker. 350-60.

Miller NS, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery, Advanced Drug Delivery Reviews. 2005; 57(11): 1666–91.

Patel KV, Patel ND, Dodiya HD, Shelat PK. Buccal bioadhesive drug delivery system: An Overview. Int J Pharm Bio Arch 2011;2(2): 600-9.

Giselle C., cleydienne C., alberto J., maria do S., allan K. et.al., Candida infections and therapeutic strategies: mechanism of action for traditional and alternative agents. frotiers in microbiology. 2018; 9(1351):3.

Harris D, Robinson JR. Drug delivery via the mucous membranes of the oral cavity. Journal of Pharmaceutical Sciences. 1992; 81(1): 1–10.

Shojaei AH. Buccal mucosa as a route for systemic drug delivery: a review. Journal of Controlled Release. 2011; 151(1): 2–9.

Divya P, Nandakumar K. Local drug delivery---periocol in periodontics. Trends Biomater Artificial Organs. 2006; 19(2): 74–80.

Pankil A. Gandhi; (2011), A review article on muco-adhesive buccal drug delivery system. IJPRD, Vol. 3(5): 159 – 173.

Coutel A, Maitani Y, Veillard M, Machida Y, Nagai T. Combined effects of pH, cosolvent and penetration enhancers on the in vitro buccal absorption of propranolol through excised hamster cheek pouch. Int. J. Pharm. 1992; 84:117-28.

Zhang X, Lua Y. Centrifugal spinning: an alternative approach to fabricate nanofibers at high speed and low cost. Polym Rev. 2014; 54(4):677–701.

Kumar P. Effect of collector on electrospinning to fabricate aligned nanofiber. Department of Biotechnology & Medical Engineering National Institute of Technology, Rourkela. 2012.

Ramakrishna S, Fujihara K, Teo W-E, Lim T-C, Ma Z (eds). An introduction to electrospinning and nanofibers. World Scientific Publishing, Singapore. 2005.

Beachley V, Wen X. Polymer nanofibrous structures: fabrication, biofunctionalization and cell interactions. Prog Polym Sci J. 2010; 35(7):868–892.

Li W-J, Shanti M, Tuan S. Electrospinning technology for nanofibrous scaffolds in tissue engineering. Nanotechnologies Life Sci. 2006; 9:135–186.

Lu T., Li Y., Chen T. Techniques for fabrication and construction of three-dimensional scaffolds for tissue engineering. Int J Nanomedicine. 2013; 8: 337–350.

Stojanovska E, Canbay E, Pampal ES, Calisir MD, Agma O. et.al., A review on non-electro nanofibre spinning techniques. RSC Adv. 2016; 87:83783–83801

Abdel-Hady F., Alzahrany A., Hamed M. Experimental validation of upward electrospinning process. ISRN Nanotechnol 2011:851317.

Wyatt P., Chien A-T., Kumar S., Yao D. Development of a gel spinning process for highstrength poly (ethylene oxide). Polym Eng Sci.2014

Liu H., Ding X., Zhou G., Li P., Wei X, Fan Y. Electrospinning of nanofibers for tissue engineering applications. J Nanomater 2013:495708.

Hamzeh S, Miraftab M, Yoosefinedaj A study of electrospun nanofiber formation process and their electrostatic analysis. J Ind Text. 2014; 44(1):147–158.

Angammana J., Jayaram H. A theoretical understanding of the physical mechanisms of electrospinning. In: Proceedings of ESA annual meeting on electrostatics, 2011; 1–9.

Ma F., Zhang N., Wei X., Yang J., Wang Y., Zhou Z. Blend-electrospun poly(vinylidene fluoride)/polydopamine membranes: Self-polymerization of dopamine and the excellent adsorption/separation abilities. J. Mater. Chem. A 2017; 5: 14430–14443.

Bhattarai S., Bachu D., Boddu S., Bhaduri S. Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery. Pharmaceutics 2018; 11(1): 5.

Muerza-Cascante L., Haylock D., Hutmacher W., Dalton D. Melt Electrospinning and Its Technologization in Tissue Engineering. Tissue Eng. Part B Rev. 2015; 21(2): 187–202.

Steyaert I., Van Der Schueren L., Rahier, H., De Clerck K. An alternative solvent system for blend electrospinning of polycaprolactone/chitosan nanofibres. Macromol. Symp. 2012; 321–322: 71–75.

Schoolaert E., Steyaert I., Vancoillie G., Geltmeyer J., Lava K., Hoogenboom R., De Clerck K. Blend electrospinning of dye-functionalized chitosan and poly(ε-caprolactone): Towards bio compatible pH-sensors. J. Mater. Chem. B 2016; 4: 4507–4516. Nanomaterials 2019; 9: 532 27 of 32

Nikmaram N., Roohinejad S., Hashemi S., Koubaa M., Barba F.J., et.al. Emulsion-based systems for fabrication of electrospun nanofibers: Food, pharmaceutical and biomedical applications. RSC Adv. 2017; 7: 28951–28964.

Kai D., Liow S., Loh, J. Biodegradable polymers for electrospinning: Towards biomedical applications. Mater. Sci. Eng. C 2014; 45: 659–670.

Liao C., Chew Y., Leong W. Aligned core–shell nanofibers delivering bioactive proteins. Nanomedicine 2006; 1: 465–471.

Yu G., Chian W., Wang X., Li Y., Li Y., Liao Z. Linear drug release membrane prepared by a modified coaxial electrospinning process. J. Membr. Sci. 2013; 428: 150–156.

Merkle V.M. Zeng L., Slepian J., Wu X. Core-shell nanofibers: Integrating the bioactivity of gelatin and the mechanical property of polyvinyl alcohol. Biopolymers 2014; 101: 336–346.

Vaidya P., Grove T., Edgar J., Goldstein S. Surface grafting of chitosan shell, polycaprolactone core fiber meshes to confer bioactivity. J. Bioact. Compat. Polym. 2015; 30: 258–274.

McClellan, P., Landis J. Recent Applications of Coaxial and Emulsion Electrospinning Methods in the Field of Tissue Engineering. BioRes. Open Access 2016; 5: 212–227.

Luo X., Xie C., Wang H., Liu C., Yan S., Li X. Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation. Int. J. Pharm. 2012; 425: 19–28.

Zhang, X.; Wang, M. Effects of Emulsion Electrospinning Parameters on the Morphology and Structure of Core-Shell Structured PLLA Fibers. Adv. Mater. Res. 2011; 410: 386–389

. Wang, C.; Tong, S.N.; Tse, Y.H.; Wang, M. Conventional Electrospinning vs. Emulsion Electrospinning: A Comparative Study on the Development of Nanofibrous Drug/Biomolecule Delivery Vehicles. Adv. Mater. Res. 2011; 410: 118–121.

Yoon, Y.I.; Park, K.E.; Lee, S.J.; Park, W.H. Fabrication of microfibrous and nano-/microfibrous scaffolds: Melt and hybrid electrospinning and surface modification of poly(L-lactic acid) with plasticizer. BioMed Res. Int. 2013: 309048.

Dalton, P.D.; Klinkhammer, K.; Salber, J.; Klee, D.; Möller, M. Direct in Vitro Electrospinning with Polymer Melts. Biomacromolecules 2006; 7(3): 686–690.

Hutmacher, D.W.; Dalton, P.D. Melt Electrospinning. Chem. Asian J. 2011; 6: 44–56.

Kim, S.J.; Jeong, L.; Lee, S.J.; Cho, D.; Park, W.H. Fabrication and surface modification of melt-electrospun poly(D,L-lactic-co-glycolic acid) microfibers. Fibers Polym. 2013; 14: 1491–1496

Zhmayev, E.; Cho, D.; Joo, Y.L. Nanofibers from gas-assisted polymer melt electrospinning. Polymer 2010; 51(18): 4140–4144.

Esfahani, H.; Jose, R.; Ramakrishna, S. Electrospun ceramic nanofiber mats today: Synthesis, properties, and applications. Materials 2017; 10(11): 1238

Jiajia Xue et.al., Electrospinning and electrospun nanofibers method, materials & applications.PubMed Central.2019; 119(8) :5298–5415

Published

2024-06-15

How to Cite

Mirgane, A. A., Borkar, S. P., Shinde, S. M., & More , P. U. (2024). Formulation Development and Evaluation of Nanofibers Containing Antifungal Drug using Electrospining Technique for the Treatment of Oral Candidacies. Asian Journal of Pharmaceutical Research and Development, 12(3), 35–42. https://doi.org/10.22270/ajprd.v11i3.1392