Antitumor Activity and Synthesis of 1, 2-Disubstituted Benzimidazoles in One-Pot Diverse Using Bismuth (III) Trifluoromethanesulfonate as Catalyst

Authors

  • A Venkateswarlu Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.
  • M Harikrishna Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.
  • P. Thriveni Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.

DOI:

https://doi.org/10.22270/ajprd.v12i1.1358

Abstract

Various 1,2-disubstituted benzimidazoles were synthesized in a facile method using Bismuth(III) trifluoromethanesulfonate. It is suggested that formation of an intermediate between the substrate, amine and solvent gives the N-arylation process. This developed protocol is demonstrated by the efficient reactions involving various substituents ranging from electron-withdrawing groups to electron-donating groups.

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Author Biographies

A Venkateswarlu, Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.

Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.

M Harikrishna, Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.

Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.

P. Thriveni, Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.

Department of Chemistry, Vikrama Simhapuri University, Nellore-524320, A.P., India.

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Published

2024-02-15 — Updated on 2024-02-15

Versions

How to Cite

Venkateswarlu, A., Harikrishna, M., & Thriveni, P. (2024). Antitumor Activity and Synthesis of 1, 2-Disubstituted Benzimidazoles in One-Pot Diverse Using Bismuth (III) Trifluoromethanesulfonate as Catalyst. Asian Journal of Pharmaceutical Research and Development, 12(1), 19–31. https://doi.org/10.22270/ajprd.v12i1.1358

Issue

Vol. 12 No. 1 (2024): Vol 12 No 1 (2024): Volume 12 Issue 1 Jan. - Feb. 2024

Section

Research Articles

Copyright (c) 2024 A Venkateswarlu, M Harikrishna, P. Thriveni

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