Antitumor Activity and Synthesis of 1, 2-Disubstituted Benzimidazoles in One-Pot Diverse Using Bismuth (III) Trifluoromethanesulfonate as Catalyst
DOI:
https://doi.org/10.22270/ajprd.v12i1.1358Abstract
Various 1,2-disubstituted benzimidazoles were synthesized in a facile method using Bismuth(III) trifluoromethanesulfonate. It is suggested that formation of an intermediate between the substrate, amine and solvent gives the N-arylation process. This developed protocol is demonstrated by the efficient reactions involving various substituents ranging from electron-withdrawing groups to electron-donating groups.
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