Ginsenoside RH1 Improves Neurological Function By Inhibiting Oxidative Stress and Promoting the Expression of Neurotrophic Factors in Cerebral Ischemia-Reperfusion Rats

Authors

  • Wang tian Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India
  • Zhang Guirong Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India
  • Wang Sensen Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India
  • Li Mingyue Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India
  • Zheng Qinpin Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India
  • Jia Xue Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

DOI:

https://doi.org/10.22270/ajprd.v11i6.1324

Keywords:

Ginsenoside Rh1,Ischemic stroke,Neurological function,Oxidative stress

Abstract

Ginseng, a valued herb in China, showed efficacies for treatment or prevention of a series of conditions in patients. Ginsenoside Rh1 is the major active component of ginseng. The aim of this study was to investigate the neuroprotective effects of ginsenoside Rh1 on injury of cerebral ischemia-reperfusion in rats. Middle cerebral artery occlusion and reperfusion were performed in male Sprague-Dawley rats. The ischemic stroke rats were treated with ginsenoside Rh1 at dose of 5 mg/kg and 10 mg/kg by gavage. After 7-day treatment, neurological functions of animals were evaluated by adhesive removal tape and beam walking tests. Neuron injury was assessed by immunohistochemical staining. The levels of MDA, BDNF, NGF and activities of SOD, CAT in the ischemic hemisphere were assayed. Treatment with ginsenoside Rh1 for 7 days could significantly improve the neurological functions (P < 0.05)and increase the number of NeuN-positive cells in rats with cerebral ischemia(P < 0.01).Ginsenoside Rh1 decreased significantly MDA level(P < 0.01) and enhanced activitiesof SOD, CAT (P < 0.05 or P < 0.01).Further measurement showed that ginsenoside Rh1 also increased the levels of BDNF, NGF of the ischemic hemisphere(P<0.05 or P<0.01).The present findings demonstrated that ginsenoside Rh1 improved neurological function by inhibiting oxidative stress and promoting the expression of neurotrophic factors after cerebral ischemia-reperfusion.

 

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Author Biographies

Wang tian, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Zhang Guirong, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Wang Sensen, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Li Mingyue, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Zheng Qinpin, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Jia Xue, Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

Department of Pharmaceutics, Netaji Subhas Chandra Bose Institiute of Pharmacy, Chakdaha, Nadia, West Bengal, India

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Published

2023-12-15

How to Cite

tian, W., Guirong, Z., Sensen, W., Mingyue, L., Qinpin, Z., & Xue, J. (2023). Ginsenoside RH1 Improves Neurological Function By Inhibiting Oxidative Stress and Promoting the Expression of Neurotrophic Factors in Cerebral Ischemia-Reperfusion Rats. Asian Journal of Pharmaceutical Research and Development, 11(6), 7–12. https://doi.org/10.22270/ajprd.v11i6.1324