Development of Co-Crystallization Technique to Improve Solubility of Anti-Diabetic Drug
DOI:
https://doi.org/10.22270/ajprd.v11i4.1282Keywords:
Co-crystals,Canagliflozin,Co-crystallization,SolubilityAbstract
Co-crystallization is a useful crystal engineering approach for changing the physiochemical and structural characteristics of drug crystals. Pharmaceutical co-crystals are nonionic supramolecular complexes that can be utilized in pharmaceutical development to change physiochemical qualities including solubility, stability, and bioavailability without changing the chemical makeup of API. Canagliflozin Hemihydrate is a anti-diabetic drug. Canagliflozin belongs to class IV drug in BCS classification. i.e. low solubility and low permeability. The major problem of this class drug is it slow solubility in biological fluids,which results into poor bioavailability after oral administration. The purpose of this study was to prepare pharmaceutical co-crystals ofCanagliflozin to enhance solubility and dissolution rate by using co-crystallization technique. The co-former used inthis study is Thiourea. The Optimized co-crystal was characterized by FTIR, XRPD, SEM and other pharmaceutical properties like solubility and melting point were alsoevaluated.
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References
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3. E. Gagniere, D. Mangin, F. Pule, A. Rivorire; Formulation of Co-crystals: Kinetic and Thermodynamic Aspects;JournalofCrystal Growth, 2009;311:2689-2695.
4. Ushma Kotak, Vipul Prajapati, Himanshu Solanki, Girish Jani, PriteshJa: Cocrystallization Technique itsRationale and Recent Progress: A Review Article, World Journal of Pharmacy and Pharmaceutical Sciences,2015;Vol.4(04):1484-1508.
5. Upadhyay N., Shukla T.P., Mathur A., Manmohan, Jha S.K.; Co-crystal: An Emerging Approch to ImprovePhysical Properties, International Journal of Pharmaceutical Sciences Review and Research, 2011; 08(01): 144-148.
6. Veerendra K. Nanjwade, F. V. Manvi, Shamrez Ali, Basavaraj K. Nanjwade and Meenaxi M. Maste; NewTrendsintheCo-crystallizationofActivePharmaceuticalIngredients,JournalofAppliedPharmaceuticalScience2011, Vol.01(08):01-05
7. TraskAV.Anoverviewofpharmaceuticalco-crystalsasintellectualproperty, Mol.Pharma, 2007;4:301–309.
8. Jayasankar A, Somwangthanaroj A, Shao ZJ, Rodrıguez- Hornedo N. Co-crystal formation during cogrindingand storage ismediatedbyamorphousphase. PharmRes, 2006;23:2381-2392.
9. MohammadAM,AmjadA,VelagaSP.Hansensolubilityparameterasatooltopredictthecocrystalformation.Int.JPharm2011;407:63-71.
10. M. S. Aziz, Chitra Gupta and l. K. Tyagi, Development of Novel Crystal Forms of Metaxalone for SolubilityEnhancement;IndianJPharmSci. 2020;82(6):974-983
11. Ankush Kumar, Kapil Kumar; Solid Dispersion- Strategy To Enhance Solubility And Dissolution Of PoorlyWater Soluble Drugs,Universal JournalofPharmaceuticalResearch2017,Vol. 2 (5),54-59
12. B.S. Furniss, A.J. Hannaford, P.W.G. Smith and A.R. Tatchell; Vogel's textbook of practical organic chemistry.5thedition,PearsonEducationIndia,1989,Page no.236-241.
13. AndreiA. Bunaciu, ElenagabrielaUdriştioiu&HassanY. Aboul-Enein; X-Ray Diffraction: Instrumentationand Applications, Critical ReviewsinAnalyticalChemistry,2015,45,289–299
14. M. S. Aziz, Chitra Gupta and l. K. Tyagi, Development of Novel Crystal Forms of Metaxalone for Solubility Enhancement; Indian J PharmSci. 2020;82(6):974-983.
Published
2023-08-13
How to Cite
Burkhande, N. S., Wankhade, V. P., Atram, S. C., Bobade, N. N., & Pande, S. D. (2023). Development of Co-Crystallization Technique to Improve Solubility of Anti-Diabetic Drug. Asian Journal of Pharmaceutical Research and Development, 11(4), 30–35. https://doi.org/10.22270/ajprd.v11i4.1282
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Section
Research Articles
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