The Effect of Steeping Water Temperature Of Cinnamon (Cinnamomum Burmannii) and Steeping Time With Test Time on the Glycemic Response of Diabetic Rats
Abstract
Diabetes Mellitus (DM) is a disease in which the body is unable to metabolize fats, proteins and carbohydrates which is characterized by high blood glucose levels or commonly known as hyperglycemia. Until 2019, 10.9 million DM cases were found in Indonesia and are suspected of continuing to increase. Cinnamon (Cinnamomum Burmannii) has several active ingredients vizcoumarin, cinnamat, cinnamaldehid, polyphenols and flavonoid can increase glucose transport by GLUT 4 in adipose cells and skeletal muscles so as to significantly reduce blood glucose. Thus, cinnamon has the potential to be a useful product for the community, namely a diabetes herbal medicine. The purpose of this research was to determine the ratio of the temperature of the cinnamon steeping water with the duration of steeping on the glycemic response of diabetic rats.
This research uses Completely randomized design (CRD) with 2 factors, namely the first factor (P): steeping water temperature (65 oC, 75 oC, and 85 oC) and brewing time (20 minutes, 25 minutes and 30 minutes) and the second factor (L): test time (30 minutes, 60 minutes, 90 minutes and 120 minutes). This study also carried out control (-) and control (+) as a preliminary study to determine the glycemic response in test animals. Each treatment will be repeated 3 times to obtain 33 experimental units. The parameters analyzed were blood sugar levels, the percentage (%) increase in blood sugar levels, and the percentage (%) decrease in blood sugar levels.
The results showed that temperature of the cinnamon steeping water (Cinnamomum Burmannii) and the duration of brewing can reduce the blood sugar levels of mice every time the test is carried out. The best treatment was obtained from the ratio of the temperature of the steeping water and the duration of steeping, namely 65 oC and brewing time for 25 minutes, determined based on the percentage decrease in blood sugar level, which is equal to 53,02%.
Downloads
References
2. WHO. 2018. Global Report on Diabetes. France: World Health Organization.
3. Mahdia, F. F., Susanto, H. S., & Adi, M. S. 2018. Hubungan antara Kebiasaan Olahraga dengan Kadar Gula Darah Penderita Diabetes Mellitus Tipe 2 (Studi di Puskesmas Rowosari Kota Semarang Tahun 2018), 6.
4. Landani, A. & Evi, K. 2018. Pengaruh Pemberian Kayu Manis (Cinnamomum cassia) Terhadap Penurunan Gula Darah Pada Penderita Diabetes Melitus Tipe 2. J Agromedicine Unila.
5. Darfiani. 2015. Pengaruh Pemberian Terapi Jahe Merah terhadap Penurunan Kadar Gkukosa Darah. 9th edition. Jakarta: EGC.
6. Chougale, A.D., Shrimant, N., Panaskar, Pradeep, M., Gurao, & Akalpita, U. Optimization of Alloxan Dose is Essential to Induce Stable Diabetes for Prolonged Period, Asian Journal Biochemistry 2007; 2(6):402-408.
7. Dewi, Rustiawati, E., & Sulastri, T. 2021. Analisis Faktor-faktor yang Berpengaruh terhadap Kejadian Hiperglikemia pada Penderita Diabetes Mellitus Tipe 2 di Poliklinik Penyakit Dalam RSUD dr. Dradjat Prawiranegara Serang. Jurnal Ilmiah Keperawatan, 2.
8. Bernardo, M. A. Research Article: Effect of Cinnamon Tea on Postprandial Glucose Concentration. Journal of Diabetes Research. 2015; 6.
9. Syahfitri, S., Silalahi, J., dan Sinaga, H. 2023. Uji Aktivitas Ekstrak Kayu Manis (Cinnamomum zeylanicum) Dan Daun Salam (Syzygium polyanthum) Serta Kombinasinya Sebagai Antidiabetes Secara In Vivo. Tesis-USU. Medan.
10. Putri, N. & Isfandiar, M. Hubungan Empat Pilar Pengendalian DM Tipe 2 dengan Rerata Kadar Gula Darah. Jurnal Berkala Epidemiologi, I 2013; (2):234-430.
11. Hermanto & Subroto. 2007. Pilih Jamu dan Herbal tanpa Efek Samping. PT Elex Media Komputindo, Jakarta.
12. Anief. 2003. Ilmu Meracik Obat, Teori dan Praktek. 161-171. Gadjah Mada University Press, Yogyakarta.
13. Ngadiwiyana. 2011. Potensi Sinamaldehid Hasil Isolasi Minyak Kayu Manis Sebagai Senyawa Antidiabetes. Majalah Farmasi Indonesia, 2011; 22(1):9 – 14.
14. Yusof, N. S. 2012. Phytochemical Studies And Biological Activity Of Cinnamomum Microphyllum. Thesis. Faculty of Resource Science and Technology. Universiti Malaysia Sarawak.
15. Aikkarach, K., Kunlaya, C. Kongkachuichai R., & Charoensiri, R. 2018. Effects of Cooking on Antioxidant Activities and Polyphenol Content of Edible Mushrooms Commonly Consumed in Thailand. Pakistan Journal of Nutrition.2018; 10 (11):1094-1103.
16. Food and Drug Administration. 2008. Guidance for Industry Diabetes Mellitus — Evaluating Cardiovascular Risk in New Antidiabetic Therapies to Treat Type 2 Diabetes. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER).
17. Lukacinova, A., Mojzis, J., Benacka, R., Racz, O., & Nistiar, F. Structure activity relationships of preventive effects of flavonoids in alloxaninduced diabetes mellitus inrats, Journal of Animal and Feed Sciences. 2008; 17:411–421.
18. Brahmachari, G. 2011. Bio-Flavonoids with Promosing Antidiabetic Potentials: a Critical Survey. Research Signpost.
19. Chougale, A.D., Shrimant, N., Panaskar, Pradeep, M., Gurao, & Akalpita, U. Optimization of Alloxan Dose is Essential to Induce Stable Diabetes for Prolonged Period, Asian Journal Biochemistry2007; 2(6):402-408.
20. Lenzen, S. The Mechanisms of Alloxan- and Streptozotocin- Induced Diabetes. Review. Diabetologia 2008; 51:216-226.

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).