A review Recent Advanced of Fabrication Techniques and Application of Micro-Needle
DOI:
https://doi.org/10.22270/ajprd.v11i3.1254Keywords:
Micro-Needle, Derma-roller, Hydro-gel Forming, Micro-Fabrication, Transdermal drug delivery system.Abstract
Micro-needles are micron-scaled medical devices used to administer vaccines, drugs, and other therapeutic agents. Micro-needles typically measure 0.1–1 mm in length. A variety of materials such as silicon, ceramic, stainless steel and polymers have been used for fabrication. Micro-needles devices are compatible with the delivery of both Small and macromolecular therapeutics. Micro-needles (MNs) are currently being utilized to enhance transdermal delivery of small and large molecules. With the emergence of micro fabrication manufacturing technology over the past several decades, (MNs) have been developed by academic laboratories and pharmaceutical companies. Micro-needle has useful in application in diseases such as type 2 Diabetes, cancer treatment, Glaucoma, and also useful application in cosmetic, vaccine therapy. The present article provides an overview of micro-needle, fabrication technique, general properties, Material and methods of fabrication techniques, application and advantages and disadvantages of micro-needle drug delivery system. Micro-needles (MNs) are currently being utilized to enhance trans-dermal delivery of small and large molecules. With the emergence of micro fabrication manufacturing technology over the past several decades, have been developed by academic laboratories and pharmaceutical companies.
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References
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28. Larraneta E, Lutton RE, Woolfson AD, Donnelly RF. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Materials Science and Engineering: R: Reports. 2016 Jun 1; 104:1-32.
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30. Bhadale RS, Londhe VY. A systematic review of carbohydrate-based microneedles: Current status and future prospects. Journal of Materials Science: Materials in Medicine. 2021 Aug;32(8):89
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32. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Advanced drug delivery reviews. 2012 Nov 1; 64(14):1547-68.
33. Rad ZF, Prewett PD, Davies GJ. An overview of micro-needle applications, materials, and fabrication methods. Beilstein Journal of Nanotechnology. 2021 Sep 13; 12(1):1034-46.
34. Wang M, Li X, Du W, Sun M, Ling G, Zhang P. Micro-needle-mediated treatment for superficial tumors by combining multiple strategies. Drug Delivery and Translational Research. 2023 Feb 3:1-21.
35. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Advanced drug delivery reviews. 2012 Nov 1S; 64(14):1547-68.
36. Gupta P, Yadav KS. Applications of microneedles in delivering drugs for various ocular diseases. Life sciences. 2019 Nov 15; 237:116907.
37. Kwon KM, Lim SM, Choi S, Kim DH, Jin HE, Jee G, Hong KJ, Kim JY. Microneedles: quick and easy delivery methods of vaccines. Clinical and experimental vaccine research. 2017 Jul 1; 6(2):156-9.
38. Bhatnagar S, Dave K, Venuganti VV. Microneedles in the clinic. Journal of controlled release. 2017 Aug 28; 260:164-82.
39. Aldawood FK, Andar A, Desai S. A comprehensive review of microneedles: Types, materials, processes, characterizations and applications. Polymers. 2021 Aug 22; 13(16):2815.
40. Jung JH, Jin SG. Micro-needle for trans-dermal drug delivery: current trends and fabrication. Journal of Pharmaceutical investigation. 2021 Mar 4:1-5.
41. Arora A, Prausnitz MR, Mitragotri S. Micro-scale devices for transdermal drug delivery. International journal of pharmaceutics. 2008 Dec 8; 364(2):227-36.
42. Menon I, Bagwe P, Gomes KB, Bajaj L, Gala R, Uddin MN, D’souza MJ, Zughaier SM. Microneedles: a new generation vaccine delivery system. Micromachines. 2021 Apr 14; 12(4):435.
43. Haj-Ahmad R, Khan H, Arshad MS, Rasekh M, Hussain A, Walsh S, Li X, Chang MW, Ahmad Z. Microneedle coating techniques for transdermal drug delivery. Pharmaceutics. 2015 Nov 5; 7(4):486-502.
44. T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, Dua K. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & pharmacotherapy. 2019 Jan 1; 109:1249-58.
45. Ita K. Transdermal delivery of drugs with microneedles—potential and challenges. Pharmaceutics. 2015 Jun 29; 7(3):90-105.
46. Xie L, Zeng H, Sun J, Qian W. Engineering microneedles for therapy and diagnosis: A survey. Micromachines. 2020 Mar 5; 11(3):271.
47. Bauleth-Ramos T, El-Sayed N, Fontana F, Lobita M, Shahbazi MA, Santos HA. Recent approaches for enhancing the performance of dissolving microneedles in drug delivery applications. Materials Today. 2023 Jan 12.
48. Khalid A, Sarwar HS, Sarfraz M, Sohail MF, Jalil A, Jardan YA, Arshad R, Tahir I, Ahmad Z. Formulation and characterization of thiolated chitosan/polyvinyl acetate based micro-needle patch for transdermal delivery of dydrogesterone. Saudi Pharmaceutical Journal. 2023 Mar 15.
49. Bystrova S, Luttge R. Micro-molding for ceramic micro-needle arrays. Microelectronic engineering. 2011 Aug 1; 88(8):1681-4.
50. Kumar AV, Kulkarni PR, Raut RA. Microneedles: promising technique for transdermal drug delivery. Int J Pharm Bio Sci. 2011;2(1):684-708.
51. Lee KJ, Jeong SS, Roh DH, Kim DY, Choi HK, Lee EH. A practical guide to the development of micro-needle systems–In clinical trials or on the market. International journal of pharmaceutics. 2020 Jan 5; 573: 118778.
52. Lutton RE, Moore J, Larrañeta E, Ligett S, Woolfson AD, Donnelly RF. Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation. Drug delivery and translational research. 2015 Aug; 5:313-31.
53. Donnelly RF, Garland MJ, Morrow DI, Migalska K, Singh TR, Majithiya R, Woolfson AD. Optical coherence tomography is a valuable tool in the study of the effects of micro-needle geometry on skin penetration characteristics and in-skin dissolution. Journal of controlled release. 2010 Nov 1; 147(3):333-41.
54. Cordeiro AS, Tekko IA, Jomaa MH, Vora L, McAlister E, Volpe-Zanutto F, Nethery M, Baine PT, Mitchell N, McNeill DW, Donnelly RF. Two-photon polymerisation 3D printing of micro-needle array templates with versatile designs: application in the development of polymeric drug delivery systems. Pharmaceutical research. 2020 Sep; 37:1-5.
55. Ashraf MW, Tayyaba S, Nisar A, Afzulpurkar N, Bodhale DW, Lomas T, Poyai A, Tuantranont A. Design, fabrication and analysis of silicon hollow microneedles for transdermal drug delivery system for treatment of hemodynamic dysfunctions. Cardiovascular engineering. 2010 Sep; 10:91-108. .
2. Priya S, Singhvi G. Microneedles-based drug delivery strategies: “A breakthrough approach for the management of pain”. Biomedicine & Pharmacotherapy. 2022 Nov 1; 155:113717.
3. Gorantla S, Dabholkar N, Sharma S, Rapalli VK, Alexander A, Singhvi G.” Chitosan-based microneedles as a potential platform for drug delivery through the skin: Trends and regulatory aspects”. International Journal of Biological Macromolecules. 2021 Aug 1; 184:438-53.
4. Ita K.” Transdermal delivery of drugs with microneedles—potential and challenges”. Pharmaceutics. 2015 Jun 29; 7(3):90-105.
5. Jacoby E, Jarrahian C, Hull HF, Zehrung D.” Opportunities and challenges in delivering influenza vaccine by micro-needle patch”. Vaccine. 2015 Sep 8; 33(37):4699-704.
6. Avcil M, Akman G, Klokkers J, Jeong D, Çelik A. “Efficacy of bioactive peptides loaded on hyaluronic acid micro-needle patches: A monocentric clinical study”. Journal of Cosmetic Dermatology. 2020 Feb; 19(2):328-37.
7. Guillot AJ, Cordeiro AS, Donnelly RF, Montesinos MC, Garrigues TM, Melero A.” Microneedle-based delivery: an overview of current applications and trends”. Pharmaceutics. 2020 Jun 19; 12(6):569.
8. Bariya SH, Gohel MC, Mehta TA, Sharma OP.” Microneedles: an emerging transdermal drug delivery system”. Journal of Pharmacy and Pharmacology. 2012 Jan; 64(1):11-29.
9. Parhi RN, Supriya ND. “Review of micro-needle based transdermal drug delivery systems”. Int. J. Pharm. Sci. Nanotechnol. 2019 May 31; 12:4511-23.
10. McConville A, Hegarty C, Davis J. Mini-review: “Assessing the potential impact of micro-needle technologies on home healthcare applications”. Medicines. 2018 Jun 8; 5(2):50.
11. Abd-El-Azim H, Tekko IA, Ali A, Ramadan A, Nafee N, Khalafallah N, Rahman T, Mcdaid W, Aly RG, Vora LK, Bell SJ.” Hollow micro-needle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer”. Journal of Controlled Release. 2022 Aug 1; 348:849-69.
12. Akhtar N. Microneedles: An innovative approach to transdermal delivery-a review. Int. J. Pharm. Pharm. Sci. 2014;6(4):18-25
13. O'Mahony C, Sebastian R, Tjulkins F, Whelan D, Bocchino A, Hu Y, O'Brien J, Scully J, Hegarty M, Blake A, Slimi I. Hollow silicon microneedles, fabricated using combined wet and dry etching techniques, for transdermal delivery and diagnostics. International Journal of Pharmaceutics. 2023 Mar 26:122888.
14. Chen Y, Chen BZ, Wang QL, Jin X, Guo XD. Fabrication of coated polymer microneedles for transdermal drug delivery. Journal of Controlled Release. 2017 Nov 10; 265:14-21.
15. Ito Y, Ohta J, Imada K, Akamatsu S, Tsuchida N, Inoue G, Inoue N, Takada K.” Dissolving microneedles to obtain rapid local anesthetic effect of lidocaine at skin tissue”. Journal of drug targeting. 2013 Sep 1; 21(8):770-5.
16. Chen B, Wei J, Tay FE, Wong YT, Iliescu C. “Silicon micro-needle array with biodegradable tips for transdermal drug delivery”. Microsystem Technologies. 2008 Jul; 14:1015-9.
17. Ripolin A, Quinn J, Larrañeta E, Vicente-Perez EM, Barry J, Donnelly RF. “Successful application of large micro-needle patches by human volunteers”. International journal of pharmaceutics. 2017 Apr 15; 521(1-2):92-101.
18. McGrath MG, Vrdoljak A, O’Mahony C, Oliveira JC, Moore AC, Crean AM. “Determination of parameters for successful spray coating of silicon micro-needle arrays”. International journal of pharmaceutics. 2011 Aug 30; 415(1-2):140-9.
19. Ainslie KM, Desai TA.” Micro-fabricated implants for applications in therapeutic delivery, tissue engineering, and biosensing”. Lab on a Chip. 2008; 8(11):1864-78.
20. Larrañeta E, Moore J, Vicente-Pérez EM, González-Vázquez P, Lutton R, Woolfson AD, Donnelly RF. ‘A proposed model membrane and test method for micro-needle insertion studies”. International journal of pharmaceutics. 2014 Sep 10; 472(1-2):65-73.
21. Andersen TE, Andersen AJ, Petersen RS, Nielsen LH, Keller SS. “Drug loaded biodegradable polymer microneedles fabricated by hot embossing”. Microelectronic Engineering. 2018 Aug 5; 195:57-61.
22. Thorat VG, Yewatkar AP. “Microneedles as a new approach for transdermal drug delivery system”. International Journal of Pharmaceutical Research and Applications Volume 8, Issue 2 Mar-Apr 2023, pp: 737-743.
23. Yang J, Liu X, Fu Y, Song Y. Recent advances of microneedles for biomedical applications: drug delivery and beyond. Acta Pharmaceutica Sinica B. 2019 May 1; 9(3):469-83.
24. Migdadi EM, Courtenay AJ, Tekko IA, McCrudden MT, Kearney MC, McAlister E, McCarthy HO, Donnelly RF. Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride. Journal of controlled release. 2018 Sep 10; 285:142-51.
25. NAYAK S, SURYAWANSHI S, Bhaskar V. Micro-needle technology for trans-dermal drug delivery : applications and combination with other enhancing techniques. Journal of Drug Delivery and Therapeutics.2016 Sep 12; 6(5):65-83.
26. Prahi RN, Supriya ND.Review of micro-needle based trans-dermal drug delivery systems. Int.J.Pharm.Sci.Nanotechnol.2019 May 31; 12: 4511-23.
27. Iriarte C, Awosika O, Rengifo-Pardo M, Ehrlich A. Review of applications of micro-needling in dermatology.
28. Larraneta E, Lutton RE, Woolfson AD, Donnelly RF. Microneedle arrays as transdermal and intradermal drug delivery systems: Materials science, manufacture and commercial development. Materials Science and Engineering: R: Reports. 2016 Jun 1; 104:1-32.
29. Avcil M, Çelik A. Microneedles in drug delivery: progress and challenges. Micromachines. 2021 Oct 28S; 12(11):1321.
30. Bhadale RS, Londhe VY. A systematic review of carbohydrate-based microneedles: Current status and future prospects. Journal of Materials Science: Materials in Medicine. 2021 Aug;32(8):89
31. Bhadale RS, Londhe VY. A systematic review of carbohydrate-based microneedles: Current status and future prospects. Journal of Materials Science: Materials in Medicine. 2021 Aug; 32(8):89.
32. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Advanced drug delivery reviews. 2012 Nov 1; 64(14):1547-68.
33. Rad ZF, Prewett PD, Davies GJ. An overview of micro-needle applications, materials, and fabrication methods. Beilstein Journal of Nanotechnology. 2021 Sep 13; 12(1):1034-46.
34. Wang M, Li X, Du W, Sun M, Ling G, Zhang P. Micro-needle-mediated treatment for superficial tumors by combining multiple strategies. Drug Delivery and Translational Research. 2023 Feb 3:1-21.
35. Kim YC, Park JH, Prausnitz MR. Microneedles for drug and vaccine delivery. Advanced drug delivery reviews. 2012 Nov 1S; 64(14):1547-68.
36. Gupta P, Yadav KS. Applications of microneedles in delivering drugs for various ocular diseases. Life sciences. 2019 Nov 15; 237:116907.
37. Kwon KM, Lim SM, Choi S, Kim DH, Jin HE, Jee G, Hong KJ, Kim JY. Microneedles: quick and easy delivery methods of vaccines. Clinical and experimental vaccine research. 2017 Jul 1; 6(2):156-9.
38. Bhatnagar S, Dave K, Venuganti VV. Microneedles in the clinic. Journal of controlled release. 2017 Aug 28; 260:164-82.
39. Aldawood FK, Andar A, Desai S. A comprehensive review of microneedles: Types, materials, processes, characterizations and applications. Polymers. 2021 Aug 22; 13(16):2815.
40. Jung JH, Jin SG. Micro-needle for trans-dermal drug delivery: current trends and fabrication. Journal of Pharmaceutical investigation. 2021 Mar 4:1-5.
41. Arora A, Prausnitz MR, Mitragotri S. Micro-scale devices for transdermal drug delivery. International journal of pharmaceutics. 2008 Dec 8; 364(2):227-36.
42. Menon I, Bagwe P, Gomes KB, Bajaj L, Gala R, Uddin MN, D’souza MJ, Zughaier SM. Microneedles: a new generation vaccine delivery system. Micromachines. 2021 Apr 14; 12(4):435.
43. Haj-Ahmad R, Khan H, Arshad MS, Rasekh M, Hussain A, Walsh S, Li X, Chang MW, Ahmad Z. Microneedle coating techniques for transdermal drug delivery. Pharmaceutics. 2015 Nov 5; 7(4):486-502.
44. T, Singhvi G, Dubey SK, Pandey MM, Gupta G, Singh M, Dua K. Microneedles: A smart approach and increasing potential for transdermal drug delivery system. Biomedicine & pharmacotherapy. 2019 Jan 1; 109:1249-58.
45. Ita K. Transdermal delivery of drugs with microneedles—potential and challenges. Pharmaceutics. 2015 Jun 29; 7(3):90-105.
46. Xie L, Zeng H, Sun J, Qian W. Engineering microneedles for therapy and diagnosis: A survey. Micromachines. 2020 Mar 5; 11(3):271.
47. Bauleth-Ramos T, El-Sayed N, Fontana F, Lobita M, Shahbazi MA, Santos HA. Recent approaches for enhancing the performance of dissolving microneedles in drug delivery applications. Materials Today. 2023 Jan 12.
48. Khalid A, Sarwar HS, Sarfraz M, Sohail MF, Jalil A, Jardan YA, Arshad R, Tahir I, Ahmad Z. Formulation and characterization of thiolated chitosan/polyvinyl acetate based micro-needle patch for transdermal delivery of dydrogesterone. Saudi Pharmaceutical Journal. 2023 Mar 15.
49. Bystrova S, Luttge R. Micro-molding for ceramic micro-needle arrays. Microelectronic engineering. 2011 Aug 1; 88(8):1681-4.
50. Kumar AV, Kulkarni PR, Raut RA. Microneedles: promising technique for transdermal drug delivery. Int J Pharm Bio Sci. 2011;2(1):684-708.
51. Lee KJ, Jeong SS, Roh DH, Kim DY, Choi HK, Lee EH. A practical guide to the development of micro-needle systems–In clinical trials or on the market. International journal of pharmaceutics. 2020 Jan 5; 573: 118778.
52. Lutton RE, Moore J, Larrañeta E, Ligett S, Woolfson AD, Donnelly RF. Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation. Drug delivery and translational research. 2015 Aug; 5:313-31.
53. Donnelly RF, Garland MJ, Morrow DI, Migalska K, Singh TR, Majithiya R, Woolfson AD. Optical coherence tomography is a valuable tool in the study of the effects of micro-needle geometry on skin penetration characteristics and in-skin dissolution. Journal of controlled release. 2010 Nov 1; 147(3):333-41.
54. Cordeiro AS, Tekko IA, Jomaa MH, Vora L, McAlister E, Volpe-Zanutto F, Nethery M, Baine PT, Mitchell N, McNeill DW, Donnelly RF. Two-photon polymerisation 3D printing of micro-needle array templates with versatile designs: application in the development of polymeric drug delivery systems. Pharmaceutical research. 2020 Sep; 37:1-5.
55. Ashraf MW, Tayyaba S, Nisar A, Afzulpurkar N, Bodhale DW, Lomas T, Poyai A, Tuantranont A. Design, fabrication and analysis of silicon hollow microneedles for transdermal drug delivery system for treatment of hemodynamic dysfunctions. Cardiovascular engineering. 2010 Sep; 10:91-108. .
Published
2023-06-15
How to Cite
Borey, V. S., Ingle, S. B., Kotwal, P. V., Jadhao, A. G., Sheikh, T. R., Nagrik, S. U., & Sanap, J. B. (2023). A review Recent Advanced of Fabrication Techniques and Application of Micro-Needle. Asian Journal of Pharmaceutical Research and Development, 11(3), 59–66. https://doi.org/10.22270/ajprd.v11i3.1254
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