Synthesis And Anti-Fungal Activity of N'-(3-Bromophenyl)-2-{[5-(4-Methylpyridine-3-Yl)-1,3,4-Oxadiazol-2-Yl] Sulfanyl} Acetohydrazides Derivatives
Abstract
A series of Pyridine derivatives were prepared and evaluated for, antibacterial and antifungal activities. The title compounds were prepared by condensation of substituted aromatic aldehydes with N'-(3-bromophenyl)-2-{[5-(4-methylpyridine-3-yl)-1,3,4-oxadiazol-2-yl] sulfanyl} acetohydrazides. The structures of all these compounds were confirmed by their spectral studies. Among synthesized compounds (DK-IB, DK-IC, DK-IG, and DK-IH) have shown good anti-fungal activity and Anti-Microbial Activity (500 µg mL-1) when compared to reference drugs Ketoconazole (25µg mL-1) and Chloramphenicol (25 µg mL-1). In this study, few derivatives showed a broad spectrum of antimicrobial activity at low concentrations. The MICs (Minimum inhibitory concentration) of some compounds are 8-16µg mL-1.
Downloads
References
2. Pandeya SN. A textbook of medicinal chemistry. 2nd ed. Varanasi: SG publisher; 2003. p. 108-13.
3. Albratty M, Alhazmi HA. Novel pyridine and pyrimidine derivatives as promising anticancer agents: A review. Arabian Journal of Chemistry. 2022 Mar 24:103846.
4. Altaf AA, Shahzad A, Gul Z, Rasool N, Badshah A, Lal B, Khan E. A review on the medicinal importance of pyridine derivatives. J. Drug Des. Med. Chem. 2015 Sep 29;1(1):1-1.
5. Mootz D, Wussow HG. Crystal structures of pyridine and pyridine trihydrate. The Journal of Chemical Physics. 1981 Aug 1;75(3):1517-22.
6. Ginsburg S, Wilson IB. Oximes of the pyridine series1. Journal of the American Chemical Society. 1957 Jan;79(2):481-5.
7. Albratty M, Alhazmi HA. Novel pyridine and pyrimidine derivatives as promising anticancer agents: A review. Arabian Journal of Chemistry. 2022 Mar 24:103846.
8. Rao GK, Kotnal RB, Pai PN. Synthesis and Biological Evaluation of 2-(3-Methyl-2-oxoquinoxalin-1 (2H)-yl)-N'- (substituted phenyl-methylidene/ethylidene) acetohydrazides. E-Journal of Chemistry. 2010 Oct 1;7(4):1435-9.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
.