Pharmacological Vunerability of Chemophoric Groups

  • Luv Kush Sardar Bhagwan Singh University, Balawala, Dehradun-248001 Uttarakhand, INDIA


The drugs target the pathological proteins for the pharmacological intervention through their vunerability of chemophoric and congate groups 1-3 at therapeutic level. They are essential for binding affinity, intrinsic efficacy and bioavailability. They are introduced in bioactive molecules by replacement of hydrogen atoms. They are implicated in SAR modifications and interactional participation with receptor or enzyme or target protein. The pharmacological influence of them is delineated here.


Keywords: Hydrogen atom, Chemophoric, pharmacological, vunerability, congate group.


Download data is not yet available.

Author Biography

Luv Kush, Sardar Bhagwan Singh University, Balawala, Dehradun-248001 Uttarakhand, INDIA

Sardar Bhagwan Singh University, Balawala, Dehradun-248001 Uttarakhand, INDIA


1. Organic functional groups
2. Congate groups Wikipedia http://www.whoc-no/atc
3. Saxton, W.A. (1963) chemical constitutions and Biological Activity 3d edn, p. 103, E&F, N Spon, London.
4. Craig, P.N. (1980), Guideline for drug and analog design. In Wolf, M.E (ed.). The Basis of Medicinal Chemistry-Burge's Medicinal Chemistry, pp. 331-348. John Wiley, New York.
5. Lne, G.M>, Jr. and Johnson. M.R. (1967) Narcotic antagonists and analgesics, Annual Reports in Medicinal Chemistry, pp. 22-32 Academic Press, New York.
6. R. (eds), ActualitesPhamacologiques, pp.221-243, Masson Paris.
7. Chu, K.C. (1980) The quantitive analysis of structure activity relationships,In Wolf, M.E (ed.). The Basis of Medicinal Chemistry/Burger's Medicinal Chemistry, pp. 393-418, John Wiley, New York.
8. Rekker, R.F. and Manhold, R. (1992) Calculation of Drug Lipophilicity, Verlag VCH, Weinheim, Germany.
9. Nemethy, G. (1967) Hydrophobic interactions, Angew. Chem. Int. Ed. Eng.6: 195-206..
10. Hansch, C. and Anderson, SM. (1967) The effect of intramolecular hydrophobic bonding on partition coefficients. J. Org. Chem. 32:2583-2586.
11. Martin, Y.C. (1978) Quantitative Drug Design. A Critical Introduction, Dekker, New York.
12. Ganellin, C.R. and Roberts: SM. (1993) Medicinal Chemistry. The Role of Organic Chemistry in Drug Research, 2 edn. Academic Press, London.
26 Views | 2 Downloads
How to Cite
Kush, L. (2022). Pharmacological Vunerability of Chemophoric Groups. Asian Journal of Pharmaceutical Research and Development, 10(6), 134-136.