Pharmacological Vunerability of Chemophoric Groups
DOI:
https://doi.org/10.22270/ajprd.v10i6.1194Keywords:
Hydrogen atom, Chemophoric, pharmacological, vunerability, congate group.Abstract
The drugs target the pathological proteins for the pharmacological intervention through their vunerability of chemophoric and congate groups 1-3 at therapeutic level. They are essential for binding affinity, intrinsic efficacy and bioavailability. They are introduced in bioactive molecules by replacement of hydrogen atoms. They are implicated in SAR modifications and interactional participation with receptor or enzyme or target protein. The pharmacological influence of them is delineated here.
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2. Congate groups Wikipedia http://www.whoc-no/atc
3. Saxton, W.A. (1963) chemical constitutions and Biological Activity 3d edn, p. 103, E&F, N Spon, London.
4. Craig, P.N. (1980), Guideline for drug and analog design. In Wolf, M.E (ed.). The Basis of Medicinal Chemistry-Burge's Medicinal Chemistry, pp. 331-348. John Wiley, New York.
5. Lne, G.M>, Jr. and Johnson. M.R. (1967) Narcotic antagonists and analgesics, Annual Reports in Medicinal Chemistry, pp. 22-32 Academic Press, New York.
6. R. (eds), ActualitesPhamacologiques, pp.221-243, Masson Paris.
7. Chu, K.C. (1980) The quantitive analysis of structure activity relationships,In Wolf, M.E (ed.). The Basis of Medicinal Chemistry/Burger's Medicinal Chemistry, pp. 393-418, John Wiley, New York.
8. Rekker, R.F. and Manhold, R. (1992) Calculation of Drug Lipophilicity, Verlag VCH, Weinheim, Germany.
9. Nemethy, G. (1967) Hydrophobic interactions, Angew. Chem. Int. Ed. Eng.6: 195-206..
10. Hansch, C. and Anderson, SM. (1967) The effect of intramolecular hydrophobic bonding on partition coefficients. J. Org. Chem. 32:2583-2586.
11. Martin, Y.C. (1978) Quantitative Drug Design. A Critical Introduction, Dekker, New York.
12. Ganellin, C.R. and Roberts: SM. (1993) Medicinal Chemistry. The Role of Organic Chemistry in Drug Research, 2 edn. Academic Press, London.
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