Formulation and Evaluation of Nail Drug Delivery System of Anti Fungal Drug
DOI:
https://doi.org/10.22270/ajprd.v10i6.1189Keywords:
Onychomycosis, nail lacquer, nail growth, stability.Abstract
The purpose of this study was to prepare nail lacquer for nail drug delivery system of anti fungal drug in order to improve the physicochemical parameters that influence the drug permeation through a nail plate to reach the systemic circulation and the neighbouring target sites. The success of local topical therapy for onychomycosis depends on the achievement of effective chemical concentrations into/through the human nail plate; therefore, a suitable antifungal drug must be coupled with an appropriate delivery method. The method should maximize the effect of the active principle by aiding its diffusion into the nail bed to levels exceeding the minimum inhibitory concentration (MIC) against local infection by dermatophytes. Thus, a suitable carrier may be needed to enhance drug penetration through the nail barrier.
The nail lacquer formulations were prepared by simple mixing method and analyzed for non volatile content, gloss, smoothness to flow, drug diffusion studies, and % drug content. Among all formulations, nail lacquer prepared with 2% oxiconazole, 6% nitrocellulose, 1% ethyl cellulose, 15% salicylic acid, 10% propylene glycol and 10% 2-H β-CD exhibited good non volatile content, drug release, drug content estimation and zone inhibition i.e. F4 formulation. The drug release profiles were achieved 93.2% at 12 h. The in vitro ungual permeation studies revealed a good in vitro in vivo correlation. Nail lacquer were substantially stable after 1 month storage at 40±2℃.
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2. Rajendra VB, Baro A, Kumari A, Dhamecha DL, Lahoti SR, Shelke SD. Transungual drug delivery: An overview, J Appl Pharm Sci 2(1); 2012:203-09.
3. Pravin DC, Shilpa PC, Pramod KK. Drug delivery through nail. Int J Pharm 2010; 11: 29–35.
4. Elkeeb R, Alikhan A, Elkeeb L. Transungual drug delivery: Current status. Int J Pharm 2010; 384: 1–8.
5. Brown M, Traynor M. Treatment of fungal nail Infections. Drug delivery report spring/summer2007[internet].Availablefrom:http://www.medpharm.co.uk/uploads/media/MedPharm FungalNailInfections.pdf.
6. Nail anatomy:[Internet]. Cited April 2021 available from http:en.wikipedia.org.
7. Kumar V, Sharma S, Naveen, Jalwal P. A comprehensive review on human nail. Int J Med Health 2017;3(10):72-74.
8. Rao V, Vijaya Sri, Padmalatha K. Formulation and evaluation of oxiconazole emulgel for topical drug delivery. Int J Curr Res 2017;9(10):58876-78.
9. Kiran S, Shekar C. Ungual drug delivery system of ketoconazole nail lacquer. Asian J Pharm 2010;1-3.
10. Metrin D, Lippold BC, In vitro permeability of the human nail and a keratin membrane from bovine hooves. J Pharm Pharmacol 1997;49(1):30-34.
11. Venjnovic I, Huonder C, Betz G. Permeation studies of novel terbinafine formulation containing hydrophobins through human nails in vitro. Int J Pharm 2010;397(2):67-76.
12. Nitrocellulose:[Internet].CitedMay2021.Availablefromhttps:en.wikipedia.org/wiki/nitrocellulose.
13. Murd S. Drug delivery to the nail following topical application. Int J Pharm 2002;236 :1-26.
14. Yadav V, Jadhav P, Dombe S, Bodhe A, Salunkhe P. Formulation and evaluation of microsponge gel for topical delivery of antifungal drug. Int J App Pharm 2017;9(4):30-37.
15. Ali R, Nagesh OH, Dipti AJ, Parthasarathi K, Kulkarni, Hani U, Rohit R, Dev DJ. Microsponge based novel drug delivery system for augemented arthritis therapy. Saudi Pharma J 2015;1-11.
16. Manavalan R, Barish, Theodore EA, Aswanivm, Venkatanarayanan R. Formulation and evaluation of medicated nail lacquer for the treatment of onychomycosis. Int J Res Pharma Nano Sci 2016;5(4):201-11.
17. Farsana. P, Shahanas B, Sebastian A, George AM. Formulation and evaluation of medicated tolnaftate nail lacquer. Global J Med Res 2018;18(5): 1-6.
18. Kobayashi Y, Miyamoto M, drug permeation through three layer of the human nail plate. J pharmacol 1999; 271-78.
19. Chandra R, Kumar S, Aggarwal A. Evaluation of nail lacquer. Indo Global J Pharma Sci 2012; 2(4):379-82.
20. Dhiman D, Kumar S, Mittal A. Formulation and evaluation of medicated nail lacquer of fluconazole. Euro J Pharma Med Res 2016;3(4): 266-70.
21. Kumar L,Verma R. In vitro evaluation of topical gel prepared using natural polymer. Int J Drug Deliv 2010; 2: 58-63.
22. Azharuddhin M, Suresh BH, Shabaraya AS, Prasad NGZ. Preparation and in vitro evaluation of antifungal nail lacquer. Int J Universal Pharm Bio Sci 2013;2(4): 78-85.
23. Sonam S, Santanu C,Supandeep SH, Transungual drung delivery system recent advances and marketed products. World J Pharma Res 2013; 2:1768-81.
24. Jaiswal M, Kumar M, Pathak K. Zero order delivery of itraconazole via polymeric micelles incorporated in situ ocular gel for the management of fungal keratitis. Coll Surf B. Biointerf 2015;130: 23-30.
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