The Potential of Albizia Saponaria compounds against Malassezia furfur: In-silico Studies Resmi Mustarichie*, Danni Ramdhani Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Indonesia
Abstract
Albizia saponaria has been reported as a potential anti-dandruff based on empirical use, but until now there is no scientific data showing its activity. Therefore, researchers are interested in testing gynecological fractions with in vitro and in silico approaches by targeting the fungus Malassezia furfur which is a fungus that plays a major role in producing dandruff. In silico testing was carried out by molecular docking method for the lanosterol 14-alpha demethylase receptor with a homology model using 48 compounds from the albazia genus as ligands. From in vitro testing of 3 fractions, n-hexane, ethyl acetate, and water, it was found that the water fraction had a moderate inhibition zone of 17.33 mm at 15% concentration and 18.67 mm at 20% concentration, showing better results. The in silico test revealed 3 metabolites in langur plants, providing better binding energy than ketoconazole (-10.1 kcal/mol), namely kaempferol 3-rhamnosyl galactosides (-11.7 kcal/mol), acasioside A (- 10.3), and albiziasaponin E (-10.7).
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