Formulation and Evaluation of Fast Disintegrating Tablets Containing Sertraline Solid Dispersion Using Plantago Ovata
The aim of the present research is to formulate Sertraline Hydochloride solid dispersion (SRT-SD) fast disintegrating tablets. The speed of onset of action of antidepressant drug is clinically important for several reasons. Fast disintegrating tablets of SRT-SD was formulated by using natural superdisintegrant adopting direct compression method to minimize time of onset of action and also become economic. The study describes formulation of solid dispersion of SRT using HPMC E5 as a carrier and further converting SRT-SD into fast disintegrating tablets utilizing Plantago ovata mucilage as natural superdisintegrant. All tablets formulations were evaluated for various pre and post compression parameters. The F1 batch showed release kinetics closest to Serta® with maximum r2 (0.9991) value was considered to be the optimized batch and showed hardness of 3.10 kg/cm2, disintegration time of 28.00 second and dissolution of 95 % in 12 min. The stability study clearly indicate that optimized batch can increase the disintegrating and dissolution time of SRT and utilized as prominent alternative for the treatment of depression.
2. P. M.Ratanaparkhi, G. P. Mohanta, and L. Upadhyay, “Review on fast dissolving tablets,” Journal of Pharmacy Research,2009; 2(1):5–12.
3. S. A. Kumar, D. Vivek, and A. Vandana, “Role of natural polymers used in floating drug delivery system,” Journal of Pharmaceutical and Scientific Innovation, 2012;1(3):11–15.
4. A.Shirwaikar, S.Prabhu, and G.Kumar, “Herbal excipients in novel drug delivery systems,” Indian Journal of PharmaceuticalSciences, 2008; 70(4):415–422.
5. R.Kumar, S.Patil, M.B.Patil, S.R.Patil, and M.S.Paschapur, “Isolation and evaluation of disintegrant properties of fenugreek seed mucilage,” International Journal of PharmTech Research, 2009; 1(4):982–996.
6. K. Prabhu Halakatti, S. Omer, S. R. Gulgannavar, and P. P. Kumar, “Formulation and evaluation of mouth disintegrating tablets of famotidine by using Hibiscus Ros Sinensis mucilage and treated agar ,”International Journal of Research in Ayurveda and Pharmacy,2010;1(2):497–505.
7. P. J. Antony and N. M. Sanghavi, “A new disintegrant for pharmaceutical dosage forms,” Drug Development and Industrial Pharmacy, 1997; 23(4):413–415.
8. R. Malviya, P. Srivastava, and G. T. Kulkarni, “Application of Mucilage’s and drug delivery: a review, “Advances in Biological Research, 2011; 5(1):7
9. B. S. Singh, “Pysllium as therapeutic and drug delivery agent,”International Journal of Pharmaceutics, 2007; 334:1–14.
10. G. Gokul Ghenge, S. D. Pande, A. Ahmad, L. Jejurkar, and T. Birari, “Development and characterization of fast disintegrating tablet of amlodipine bisulfate using mucilage of plantago ovata as a natural superdisintegrant,” International Journal of Pharm Tech Research,2011; 3(2):938–945.
11. H. Abdul Ahad, R. Sreenivsulu, K. K. Reddy, K. Kavitha, B. Sumapadmaja, and V.K.Reddy ,“ Isolation and characterization of Ficus indica fruit mucilage, ”Journal of Pharmacy Research, 2011; 4(3):726–727.
12. L. Prabakaran and D. Sendhil, “ Formulation development of patient friendly dosage form: all in one natural excipient as binder, diluent and disintegrant,” International Journal of ,vol.3,supplement 2011; 2: 97–10.
13. Gaikwad, Vinay D., Vishal D. Yadav, and Prakash D. Jadhav. "Formulation and evaluation of floating matrix tablets of diltiazem hydrochloride." Asian Journal of Pharmaceutics (AJP): Free full text articles from Asian J Pharm 6.4 (2012).
14. Colombo M, de Lima Melchiades G, Michels L, Figueiró F, Bassani V, Teixeira H et al. Solid Dispersion of Kaempferol: Formulation Development, Characterization, and Oral Bioavailability Assessment. AAPS Pharm Sci Tech. 2019; 20(3).
15. Amit S. Patil, Anil M. Pethe, Quality by Design (QbD): A new concept for development of quality pharmaceuticals. International Journal of Pharmaceutical Quality Assurance. April-June, 2013; 4(2).13-19.
16. Zhang Q, Effect of HPMCAS on recrystallization inhibition of Nimodipine solid dispersions prepared by hot-melt extrusion and dissolution enhancement of Nimodipine tablets. Colloids Surf B Biointerfaces., 2018; 172:118-126.
17. Gudas GK, Manasa B, Rajesham VV, Kumar SK, Kumari JP. Formulation and evaluation of fast dissolving tablets of chlorpromazine hydrochloride. Journal of Pharm Sci Tech 2010; 2(1): 99-102.
18. Kumar DN, Raju SA, Shirsand SB, Para MS. Design of fast dissolving granisetron tablets using novel coprocessed superdisintegrants. Int J Pharm Sci Rev Res 2010; 1(1):58-62.
19. Yamashita K, Nakate T, Okimoto K, Ohike A, Tokunaga Y, Ibuki R Establishment of new preparation method for solid dispersion of formulation of tacrolimus. Int J. Pharm. 2003 ; 267(1-2):79-91.
20. Vijaya Vitthal et al. (QbD): A new concept for development of quality Investigation on Polymorphs of Apixaban, an Anticoagulant Drug: Study of Phase Transformations and Designing Efficient Process for their Preparation, World Journal of Pharm Sci. 2015; 3(3): 663-677.
21. Rashmi Dahima, Amit Gupta and Devashish Rathore, Quality by Design (QbD) Approach for Formulation Development of Hydralazine Hydrochloride Tablets, Journal of Chemical and Pharmaceutical Research., 2016; 8(5):336-341.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
AUTHORS WHO PUBLISH WITH THIS JOURNAL AGREE TO THE FOLLOWING TERMS:
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 Unported License. that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).