Therapeutic Effect of Herbal Medicinal Plants on Polycystic Ovarian Syndrome: A Review
DOI:
https://doi.org/10.22270/ajprd.v10i6.1095Keywords:
Ovary, cysts, hormone, obesity, herbs, metabolismAbstract
Polycystic ovarian syndrome (PCOS) problem affects mature female in entire world. Menstrual irregularity, infertility, and hirsutism symptoms are all caused by PCOS patients' altered androgen and oestrogen metabolism and secretion rates. PCOS is associated to insulin resistance, obesity, and amplified concentration of hormones found in male. Both allopathic and natural treatments can be used to treat PCOS, which is becoming more common, as well as the physical and emotional issues it is connected with. Changes in sex hormones can also contribute to the development of this disease. Asparagus racemosus, Bauhinia variegata, Nigella sativa, Vitex negundo, Cocus nucifera, and other herbal plants have bioactive compounds that are safe and efficient for treating PCOS and associated complications. This review attempts to comprehend the bioactive components of natural medicinal plants that are either utilised alone or in combination to treat this condition.
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References
1. Bani MM, Majdi SA. Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH. Asian Pac. J. Cancer Prev. 2017;18(1):17-21.
2. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet 2007; 370(9588): 685-697.
3. Franks S, McCarthy MI, Hardy K. Development of polycystic ovary syndrome: involvement of genetic and environmental factors. Int. J. Androl. 2006; 29(1): 278-285.
4. Azziz R. et al. Te prevalence and features of the polycystic ovary syndrome in an unselected population. J. Clin. Endocrinol. Metab.2004; 89(6):2745-2749.
5. Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. Te prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum. Reprod. 2016; 31(12):2841-2855.
6. Azziz R, Marin C, Hoq L, Badamgarav E, Song P. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J. Clin. Endocrinol. Metab. 2005;90(8): 4650-4658.
7. Chen X. et al. Prevalence of polycystic ovary syndrome in unselected women from southern China. Eur. J. Obstet. Gynecol. Reprod. Biol.2008; 139(1): 59-64.
8. Bremer AA. Polycystic ovary syndrome in the pediatric population. Metab. Syndr. Relat. Disord. 2010;8(5):375-394.
9. Liu J. et al. Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod. 2021; 36(4);1108-1119.
10. Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H. Endometriosis: The pathophysiology as an estrogen-dependent disease. J. Steroid Biochem. Mol. Biol. 2002; 83(1-5): 149-155.
11. Alimi Y, Iwanaga, J, Loukas, M, Tubbs RS. The clinical anatomy of endometriosis: A review. Cureus, 2018; 10(9).
12. Olive DL, Schwartz LB. Endometriosis. N, Engl. J. Med., 1993,328(24):1759-1769.
13. Ozkan S, Murk W, Arici A. Endometriosis and infertility: Epidemiology and evidence-based treatments. Ann. N.Y. Acad. Sci., 2008; 1127: 92-100.
14. McLaren J, Prentice A. New aspects of pathogenesis of endometriosis. Curr. Obstet. Gynaecol., 1996: 6(2): 85-91.
15. Sasikala SL, Shamila S. A novel Ayurvedic medicine asokarishtam in the treatment of Letrozole induced PCOS in rat. J Cell Tiss Res. 1992; 9: 91-104.
16. Shubhashree MN. Female infertility. Researches on female infertility, ayurvedline - Ayurvedic drug index. 12th ed., 2012. 1358-1365
17. Gaware VM, Parjane SK, Merekar AN, Pattan SR, Dighe NS, Kuchekar BS. Female infertility and its treatment by alternative medicine - A review. J Chem Pharm Res. 2009; 1:148-162.
18. Wang Y, Xiang T, Xia X, Zhang H, Geng S, Yang G, Qiu S, He Y, Liu R, Li L, Liu H, Li K, Zhang L, Liang Z, He J. Elevated circulating GPHB5 levels in women with insulin resistance and polycystic ovary syndrome: A cross-sectional study and multiple intervention studies. Front Endocrinol (Lausanne). 2022; 8;13:1010714.
19. Krishnan A, Muthusami S. Hormonal alterations in PCOS and its influence on bone metabolism. J Endocrinol. 2017;232(2):R99-R113.
20. Ajmal N, Khan SZ, Shaikh R. Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article. Eur J Obstet Gynecol Reprod Biol X. 2019; 8;3:100060.
21. Nautiyal H, Imam SS, Alshehri S, Ghoneim MM, Afzal M, Alzarea SI, Güven E, Al-Abbasi FA, Kazmi I. Polycystic Ovarian Syndrome: A Complex Disease with a Genetics Approach. Biomedicines. 2022;24:10(3):540.
22. Witchel SF, Burghard AC, Tao RH, Oberfield SE. The diagnosis and treatment of PCOS in adolescents: an update. Curr Opin Pediatr. 2019;31(4):562-569.
23. Zeind, CS, Carvalho MG. Applied Therapeutics: The Clinical Use of Drugs; Wolters Kluwer Health: Philadelphia, PA, USA, 2017.
24. Liu HY, Liu JQ, Mai ZX, Zeng YT. A Subpathway-Based Method of Drug Reposition for Polycystic Ovary Syndrome. Reprod. Sci. 2014;22:423-430.
25. Zhang X, Zheng Y, Guo Y, Lai Z. The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. Int. J. Endocrinol. 2019; 4386401.
26. Brennan L, Teede H, Skouteris H, Linardon J, Hill B, Morann L. Lifestyle and Behavioral Management of Polycystic Ovary Syndrome. J. Women’s Health 2017; 26:836-848.
27. Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. Nutritional management in women with polycystic ovary syndrome: A review study. Diabetes Metab. Syndr. Clin. Res. Rev. 2017;11: S429-S432.
28. Hakimi O, Cameron LC. Effect of Exercise on Ovulation: A Systematic Review. Sports Med. 2016;47:1555-1567.
29. Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S,Yan Q. Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome. J. Cell. Physiol. 2018; 234:7435-7447.
30. Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska A, Smolarczyk R, Meczekalski B. Chronic Low Grade Inflammation in Pathogenesis of PCOS. Int. J. Mol. Sci. 2021; 22: 3789.
31. Jia LY, Feng JX., Li JL, Liu FY, Xie LZ, Luo SJ, Han FJ. The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism. Evid.-Based Complement. Altern. Med. 2021; 2021: 5555315.
32. Shen W, Jin B, Pan Y, Han Y, You T, Zhang Z, Qu Y, Liu S, Zhang Y. The Effects of Traditional Chinese MedicineAssociated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome. Evid.-Based Complement. Altern. Med. 2021; 2021: 6619597.
33. Raja KN, Stener-Victorin E, Wu X, Legro R.S. The physiological basis of complementary and alternative medicines for polycystic ovary syndrome. Am. J. Physiol. Metab. 2011; 301: E1-E10.
34. Zhang Y, Guo X, Ma S, Ma H, Li H, Wang Y, Qin Z, Wu X, Han Y, Han Y. The Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome. Evid.-Based Complement. Altern. Med. 2021; 2021: 6678398.
35. Shirvani-Rad S, Tabatabaei-Malazy O, Mohseni S, Hasani-Ranjbar S, Soroush AR, Hoseini-Tavassol Z, Ejtahed HS, Larijani B. Probiotics as a Complementary Therapy for Management of Obesity: A Systematic Review. Evid.-Based Complement. Altern. Med. 2021; 2021:6688450.
36. Li Y, Peng C, Cao G, Li W, Hou L. Tai chi for overweight/obese adolescent and young women with polycystic ovary syndrome: Study protocol for a randomized controlled trial. Trials 2018; 19: 512.
37. Mohseni M, Eghbali M, Bahrami H, Dastaran F, Amini L. Yoga Effects on Anthropometric Indices and Polycystic Ovary Syndrome Symptoms in Women Undergoing Infertility Treatment: A Randomized Controlled Clinical Trial. Evid.-Based Complement. Altern. Med. 2021; 2021: 5564824.
38. Legro RS, Duguech LMM. Pharmacologic Treatment of Polycystic Ovary Syndrome: Alternate and Future Paths. Semin. Reprod. Med. 2017; 35 :326-343.
39. Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba AJ, Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis. J. Ovarian Res. 2014; 7: 21.
40. Crandall, JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N. Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance. J. Gerontol. Ser. A Boil. Sci. Med. Sci. 2012; 67:1307-1312.
41. Rondanelli M, Infantino V, Riva A, Petrangolini G, Faliva MA, Peroni G, Naso M, Nichetti M, Spadaccini D, Gasparri C et al. Polycystic ovary syndrome management: A review of the possible amazing role of berberine. Arch. Gynecol. Obstet. 2020; 301: 53-60.
42. Naka KK, Kalantaridou SN, Kravariti M, Bechlioulis A, Kazakos N, Calis K.A, Makrigiannakis A, Katsouras CS, Chrousos GP, Tsatsoulis A. et al. Effect of the insulin sensitizers metformin and pioglitazone on endothelial function in young women with polycystic ovary syndrome: A prospective randomized study. Fertil. Steril. 2011; 95:203-209.
43. Farshchi H, Rane A, Love A, Kennedy RL. Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management. J Obstet Gynaecol. 2007; 27(8):762-73.
44. Foster C, Al-Zubeidi H. Menstrual Irregularities. Pediatr Ann. 2018;1:47(1):e23-e28.
45. Li SY, Song Z, Song MJ, Qin JW, Zhao ML, Yang ZM. Impaired receptivity and decidualization in DHEA-induced PCOS mice. Sci Rep. 2016;7:6:38134.
46. Choudhary K, Singh R, Garg A, Verma N, Purohit A, Deora D. An updated overview of polycystic ovary syndrome. Int. J. Biol. Sci., 2019;7(3):1-13.
47. Merviel P, James P, Bouée S, Le Guillou M, Rince C, Nachtergaele C, Kerlan V. Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies. Reprod Health. 2021; 19:18(1):13.
48. Micic DD, Toplak H, Micic DD, Polovina SP. Reproductive outcomes after bariatric surgery in women. Wien Klin Wochenschr. 2022; 134(1-2):56-62.
49. Saiyed A, Jahan N, Makbul SAA, Ansari M, Bano H, Habib SH. Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res. 2016; 5(4):293-300.
50. Pothuraju R, Sharma RK, Chagalamarri J, Jangra S, Kumar Kavadi P. A systematic review of Gymnema sylvestre in obesity and diabetes management. J Sci Food Agric. 2014; 30;94(5):834-40.
51. Maharjan R, Nagar P, Nampoothiri L. Effect of Aloe barbadensis Mill. Formulation on Letrozole induced polycystic ovarian syndrome rat model. J Ayurveda Integr. Med. 2010; 1(4):273-9
52. Review P. Anti-androgenic effect of Symplocos racemosa Roxb. against letrozole induced polycystic ovary using rat model. J Coast Life Med. 2013; 1(4):309-14.
53. Baby BT, Rani S, Rasheed SP, Bency Baby CT. Polycystic ovarian syndrome: Therapeutic potential of herbal remedies-A review. Int J Herb Med IJHM. 2016; 91(45):91-6.
54. Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iran J Basic Med Sci. 2018; 21(6):645-50
55. Satapathy S, Das N, Bandyopadhyay D, Mahapatra SC, Sahu DS, Meda M. Effect of tulsi (ocimum sanctum linn.) supplementation on metabolic parameters and liver enzymes in young overweight and obese subjects. Indian J. Clin. Biochem. 2017; 32(3):357-363.
56. Pachiappan S, Matheswaran S, Saravanan PP, Gayathiri M. Medicinal plants for polycystic ovary syndrome: A review of phytomedicine research. Int. J. Herb, 2017; 5(2):78-80.
57. Khanage SG, Subhash TY, Bhaiyyasaheb IR. Herbal drugs for the treatment of polycystic ovary syndrome (PCOS) and its complications. Pharm. Res., 2019:2(1):5-13.
58. Samak G, Rao SM, Kedlaya R, Vasudevan DM. Hypolipidemic efficacy of Ocimum sanctum in the prevention of Atherogenesis in male albino rabbits. Pharmacologyonline, 2007; 2:115-117.
59. Khandelwal R, Nathani S. An ayurvedic approach to PCOS: A leading cause of female infertility. Int. J. Ayurveda Res., 2016; 1(3): 77-82.
60. Healthy living. Saraca asoca bark. Available from: https://healthyliving.natureloc.com/wp-content/uploads/2016/08/Ashoka-Bark4.jpg [Accessed January 12, 2021]
61. Etsystatic. Tinospora cordifolia. Available from: https://i.etsystatic.- com/11266331/r/il/660c45/2374644217/il_570xN.2374644217_- muzq.jpg [Accessed January 10, 2021]
62. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac. J. Trop. Biomed., 2013: 3(5):337-352.
63. Sheeraz, M. Rational approach towards the role of kalawnji (nigella sativa linn) in marz-e– akyas khusyatur rehm (polycystic ovarian syndrome)-a review. Indo Am. J. Pharm., 2018; 8(5): 1089-1096.
64. Nafiu AB, Alimi S, Babalola A. Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. J. Complement. Med. Res, 2019; 10(4): 186-199.
65. Encyclopedia Britannica. Black cumin. Available from: https://www.britannica.com/plant/black-cumin [Accessed June 13, 2021]
66. Belwal T, Devkota HP, Singh MK, Sharma R. Chapter 3.40 - St. John’s Wort (Hypericumperforatum), nonvitamin and nonmineral. Nutritional Supplements; Academic Press, 2019; pp. 415-432.
67. Mitsi C, Efthimiou K. Infertility: Psychological-psychopathological consequences and cognitive-behavioural interventions]. Psychiatriki, 2014:25(4):293-302.
68. O’Reilly E, Sevigny M, Sabarre KA, Phillips KP. Perspectives of complementary and alternative medicine (CAM) practitioners in the support and treatment of infertility. BMC Complement. Altern. Med., 2014:14: 394.
69. Rayburn WF, Gonzalez CL, Christensen HD, Stewart JD. Effect of prenatally administered hypericum (St John’s wort) on growth and physical maturation of mouse offspring. Am. J. Obstet. Gynecol., 2001; 184(2): 191-195.
70. Canning S, Waterman M, Orsi N, Ayres J, Simpson N, Dye L. The efficacy of hypericumperforatum (st john’s wort) for the treatment of premenstrual syndrome: A randomized, doubleblind, placebo-controlled trial. CNS Drugs, 2010;24(3): 207-225.
71. Insulite health PCOS. Herbal remedies for PCOS. Available from: https://pcos.com/herbal-remedies/ [Accessed January 3, 2021]
72. Nariyal V, Sharma P. Kanchnar (Bauhinia variegata) as a medicinal herb: A systematic review. Int. J. Adv. Res. (Indore), 2017; 5(9): 587-591.
73. Netmeds. Kanchanar Guggulu: This ayurvedic formulation treats hormonal imbalance. Available from: https://www.netmeds.- com/health-library/post/kanchanar-guggulu-this-ayurvedic-formulation-treats-hormonal-imbalance [Accessed December 27, 2020]
74. Sudheerkumar K, Seetaramswamy S, Babu KA, Kumar PK. Phyto pharmacognostical and isolation of chemical constituents from bauhinia variegata leaf extract. J. Pharmacogn. Phytochem., 2015;(1): 189-191.
75. Farooq U, Khan S, Naz A, Khan A, Khan AA. Chinese Journal of Natural Medicine, 2017; 15(12): 9442017.
76. Fenkci V, Fenkci S, Yilmazer M, Serteser M. Fertility and Sterility, 2003;80(1):123
77. Gautam L, Shrestha s, Wagle P, Tamrakar B, Scientific World, 1970; 6(6): 2630
78. Irchhaiya R, Kumar A, Gurjar H, Gupta N, Kumar S, Kumar M. International Journal of Pharmacognosy, 2014;1(5):279
79. Kakadia N, Patel P, Deshpande S, Shah G. Journal of Traditional and Complementary Medicine, 2019;9(4):336.
80. Saiyed A, Jahan N, Makbul SAA, Ansari M, Bano H, Habib SH. Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res. 2016;5(4):293–300.
81. Bency Baby T, Smitha Rani, Remya K, Shebina Rasheed P, Azeem AK. Polycystic ovarian syndrome: Therapeutic potential of herbal remedies- A review. International Journal of Herbal Medicine. 2016; 4(5):91-96.
82. Shari Lieberman. A Review of the Effectiveness of Cimicifuga racemosa (Black Cohosh) for the Symptoms of Menopause. Journal of Women's Health. 2009; 7(5):525-529.
83. Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C et al. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. 2002; 34(6):367- 72.
84. Sharma Meenakshi, Sharma Gyan Prakash, Meena Mahendra Singh. Role of traditional ayurvedic herbs in gynocological disorders. A Demand of 21st Century. International Journal of Applied Ayurved Research. 2014; 1(8):2347-6362.
85. Grifola frondosa. https://en.wikipedia.org/.com.
86. Tori Hudson ND. Maitake Mushroom Extract and Polycystic Ovarian Syndrome. Natural Medicine Journal. 2011; 3(2):2157-6769.
87. Talpur N, Echard BW, Yasmin T. et al. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (–)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem 2003;252:369–377.
88. 10 home remedies for polycystic ovary syndrome. https://pcos.com/herbal-remedies/.
89. 5Ayurvedic Medicines for PCOS | PCOD- Poly Cystic Ovarian Syndrome & Disease. https://curaayurveda.wordpress.com. 12 April, 2014.
90. Kumar Santosh, Mehla RK, Dang AK. Use of shatavari (asparagus racemosus) as a galactopoietic and therapeutic herb-A review. Agric. Rev. 2008; 29(2):132- 138.
2. Norman RJ, Dewailly D, Legro RS, Hickey TE. Polycystic ovary syndrome. Lancet 2007; 370(9588): 685-697.
3. Franks S, McCarthy MI, Hardy K. Development of polycystic ovary syndrome: involvement of genetic and environmental factors. Int. J. Androl. 2006; 29(1): 278-285.
4. Azziz R. et al. Te prevalence and features of the polycystic ovary syndrome in an unselected population. J. Clin. Endocrinol. Metab.2004; 89(6):2745-2749.
5. Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO. Te prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum. Reprod. 2016; 31(12):2841-2855.
6. Azziz R, Marin C, Hoq L, Badamgarav E, Song P. Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J. Clin. Endocrinol. Metab. 2005;90(8): 4650-4658.
7. Chen X. et al. Prevalence of polycystic ovary syndrome in unselected women from southern China. Eur. J. Obstet. Gynecol. Reprod. Biol.2008; 139(1): 59-64.
8. Bremer AA. Polycystic ovary syndrome in the pediatric population. Metab. Syndr. Relat. Disord. 2010;8(5):375-394.
9. Liu J. et al. Measuring the global disease burden of polycystic ovary syndrome in 194 countries: Global Burden of Disease Study 2017. Hum Reprod. 2021; 36(4);1108-1119.
10. Kitawaki J, Kado N, Ishihara H, Koshiba H, Kitaoka Y, Honjo H. Endometriosis: The pathophysiology as an estrogen-dependent disease. J. Steroid Biochem. Mol. Biol. 2002; 83(1-5): 149-155.
11. Alimi Y, Iwanaga, J, Loukas, M, Tubbs RS. The clinical anatomy of endometriosis: A review. Cureus, 2018; 10(9).
12. Olive DL, Schwartz LB. Endometriosis. N, Engl. J. Med., 1993,328(24):1759-1769.
13. Ozkan S, Murk W, Arici A. Endometriosis and infertility: Epidemiology and evidence-based treatments. Ann. N.Y. Acad. Sci., 2008; 1127: 92-100.
14. McLaren J, Prentice A. New aspects of pathogenesis of endometriosis. Curr. Obstet. Gynaecol., 1996: 6(2): 85-91.
15. Sasikala SL, Shamila S. A novel Ayurvedic medicine asokarishtam in the treatment of Letrozole induced PCOS in rat. J Cell Tiss Res. 1992; 9: 91-104.
16. Shubhashree MN. Female infertility. Researches on female infertility, ayurvedline - Ayurvedic drug index. 12th ed., 2012. 1358-1365
17. Gaware VM, Parjane SK, Merekar AN, Pattan SR, Dighe NS, Kuchekar BS. Female infertility and its treatment by alternative medicine - A review. J Chem Pharm Res. 2009; 1:148-162.
18. Wang Y, Xiang T, Xia X, Zhang H, Geng S, Yang G, Qiu S, He Y, Liu R, Li L, Liu H, Li K, Zhang L, Liang Z, He J. Elevated circulating GPHB5 levels in women with insulin resistance and polycystic ovary syndrome: A cross-sectional study and multiple intervention studies. Front Endocrinol (Lausanne). 2022; 8;13:1010714.
19. Krishnan A, Muthusami S. Hormonal alterations in PCOS and its influence on bone metabolism. J Endocrinol. 2017;232(2):R99-R113.
20. Ajmal N, Khan SZ, Shaikh R. Polycystic ovary syndrome (PCOS) and genetic predisposition: A review article. Eur J Obstet Gynecol Reprod Biol X. 2019; 8;3:100060.
21. Nautiyal H, Imam SS, Alshehri S, Ghoneim MM, Afzal M, Alzarea SI, Güven E, Al-Abbasi FA, Kazmi I. Polycystic Ovarian Syndrome: A Complex Disease with a Genetics Approach. Biomedicines. 2022;24:10(3):540.
22. Witchel SF, Burghard AC, Tao RH, Oberfield SE. The diagnosis and treatment of PCOS in adolescents: an update. Curr Opin Pediatr. 2019;31(4):562-569.
23. Zeind, CS, Carvalho MG. Applied Therapeutics: The Clinical Use of Drugs; Wolters Kluwer Health: Philadelphia, PA, USA, 2017.
24. Liu HY, Liu JQ, Mai ZX, Zeng YT. A Subpathway-Based Method of Drug Reposition for Polycystic Ovary Syndrome. Reprod. Sci. 2014;22:423-430.
25. Zhang X, Zheng Y, Guo Y, Lai Z. The Effect of Low Carbohydrate Diet on Polycystic Ovary Syndrome: A Meta-Analysis of Randomized Controlled Trials. Int. J. Endocrinol. 2019; 4386401.
26. Brennan L, Teede H, Skouteris H, Linardon J, Hill B, Morann L. Lifestyle and Behavioral Management of Polycystic Ovary Syndrome. J. Women’s Health 2017; 26:836-848.
27. Faghfoori Z, Fazelian S, Shadnoush M, Goodarzi R. Nutritional management in women with polycystic ovary syndrome: A review study. Diabetes Metab. Syndr. Clin. Res. Rev. 2017;11: S429-S432.
28. Hakimi O, Cameron LC. Effect of Exercise on Ovulation: A Systematic Review. Sports Med. 2016;47:1555-1567.
29. Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S,Yan Q. Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome. J. Cell. Physiol. 2018; 234:7435-7447.
30. Rudnicka E, Suchta K, Grymowicz M, Calik-Ksepka A, Smolarczyk K, Duszewska A, Smolarczyk R, Meczekalski B. Chronic Low Grade Inflammation in Pathogenesis of PCOS. Int. J. Mol. Sci. 2021; 22: 3789.
31. Jia LY, Feng JX., Li JL, Liu FY, Xie LZ, Luo SJ, Han FJ. The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism. Evid.-Based Complement. Altern. Med. 2021; 2021: 5555315.
32. Shen W, Jin B, Pan Y, Han Y, You T, Zhang Z, Qu Y, Liu S, Zhang Y. The Effects of Traditional Chinese MedicineAssociated Complementary and Alternative Medicine on Women with Polycystic Ovary Syndrome. Evid.-Based Complement. Altern. Med. 2021; 2021: 6619597.
33. Raja KN, Stener-Victorin E, Wu X, Legro R.S. The physiological basis of complementary and alternative medicines for polycystic ovary syndrome. Am. J. Physiol. Metab. 2011; 301: E1-E10.
34. Zhang Y, Guo X, Ma S, Ma H, Li H, Wang Y, Qin Z, Wu X, Han Y, Han Y. The Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome. Evid.-Based Complement. Altern. Med. 2021; 2021: 6678398.
35. Shirvani-Rad S, Tabatabaei-Malazy O, Mohseni S, Hasani-Ranjbar S, Soroush AR, Hoseini-Tavassol Z, Ejtahed HS, Larijani B. Probiotics as a Complementary Therapy for Management of Obesity: A Systematic Review. Evid.-Based Complement. Altern. Med. 2021; 2021:6688450.
36. Li Y, Peng C, Cao G, Li W, Hou L. Tai chi for overweight/obese adolescent and young women with polycystic ovary syndrome: Study protocol for a randomized controlled trial. Trials 2018; 19: 512.
37. Mohseni M, Eghbali M, Bahrami H, Dastaran F, Amini L. Yoga Effects on Anthropometric Indices and Polycystic Ovary Syndrome Symptoms in Women Undergoing Infertility Treatment: A Randomized Controlled Clinical Trial. Evid.-Based Complement. Altern. Med. 2021; 2021: 5564824.
38. Legro RS, Duguech LMM. Pharmacologic Treatment of Polycystic Ovary Syndrome: Alternate and Future Paths. Semin. Reprod. Med. 2017; 35 :326-343.
39. Ortega I, Villanueva JA, Wong DH, Cress AB, Sokalska A, Stanley SD, Duleba AJ, Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis. J. Ovarian Res. 2014; 7: 21.
40. Crandall, JP, Oram V, Trandafirescu G, Reid M, Kishore P, Hawkins M, Cohen HW, Barzilai N. Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance. J. Gerontol. Ser. A Boil. Sci. Med. Sci. 2012; 67:1307-1312.
41. Rondanelli M, Infantino V, Riva A, Petrangolini G, Faliva MA, Peroni G, Naso M, Nichetti M, Spadaccini D, Gasparri C et al. Polycystic ovary syndrome management: A review of the possible amazing role of berberine. Arch. Gynecol. Obstet. 2020; 301: 53-60.
42. Naka KK, Kalantaridou SN, Kravariti M, Bechlioulis A, Kazakos N, Calis K.A, Makrigiannakis A, Katsouras CS, Chrousos GP, Tsatsoulis A. et al. Effect of the insulin sensitizers metformin and pioglitazone on endothelial function in young women with polycystic ovary syndrome: A prospective randomized study. Fertil. Steril. 2011; 95:203-209.
43. Farshchi H, Rane A, Love A, Kennedy RL. Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management. J Obstet Gynaecol. 2007; 27(8):762-73.
44. Foster C, Al-Zubeidi H. Menstrual Irregularities. Pediatr Ann. 2018;1:47(1):e23-e28.
45. Li SY, Song Z, Song MJ, Qin JW, Zhao ML, Yang ZM. Impaired receptivity and decidualization in DHEA-induced PCOS mice. Sci Rep. 2016;7:6:38134.
46. Choudhary K, Singh R, Garg A, Verma N, Purohit A, Deora D. An updated overview of polycystic ovary syndrome. Int. J. Biol. Sci., 2019;7(3):1-13.
47. Merviel P, James P, Bouée S, Le Guillou M, Rince C, Nachtergaele C, Kerlan V. Impact of myo-inositol treatment in women with polycystic ovary syndrome in assisted reproductive technologies. Reprod Health. 2021; 19:18(1):13.
48. Micic DD, Toplak H, Micic DD, Polovina SP. Reproductive outcomes after bariatric surgery in women. Wien Klin Wochenschr. 2022; 134(1-2):56-62.
49. Saiyed A, Jahan N, Makbul SAA, Ansari M, Bano H, Habib SH. Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res. 2016; 5(4):293-300.
50. Pothuraju R, Sharma RK, Chagalamarri J, Jangra S, Kumar Kavadi P. A systematic review of Gymnema sylvestre in obesity and diabetes management. J Sci Food Agric. 2014; 30;94(5):834-40.
51. Maharjan R, Nagar P, Nampoothiri L. Effect of Aloe barbadensis Mill. Formulation on Letrozole induced polycystic ovarian syndrome rat model. J Ayurveda Integr. Med. 2010; 1(4):273-9
52. Review P. Anti-androgenic effect of Symplocos racemosa Roxb. against letrozole induced polycystic ovary using rat model. J Coast Life Med. 2013; 1(4):309-14.
53. Baby BT, Rani S, Rasheed SP, Bency Baby CT. Polycystic ovarian syndrome: Therapeutic potential of herbal remedies-A review. Int J Herb Med IJHM. 2016; 91(45):91-6.
54. Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iran J Basic Med Sci. 2018; 21(6):645-50
55. Satapathy S, Das N, Bandyopadhyay D, Mahapatra SC, Sahu DS, Meda M. Effect of tulsi (ocimum sanctum linn.) supplementation on metabolic parameters and liver enzymes in young overweight and obese subjects. Indian J. Clin. Biochem. 2017; 32(3):357-363.
56. Pachiappan S, Matheswaran S, Saravanan PP, Gayathiri M. Medicinal plants for polycystic ovary syndrome: A review of phytomedicine research. Int. J. Herb, 2017; 5(2):78-80.
57. Khanage SG, Subhash TY, Bhaiyyasaheb IR. Herbal drugs for the treatment of polycystic ovary syndrome (PCOS) and its complications. Pharm. Res., 2019:2(1):5-13.
58. Samak G, Rao SM, Kedlaya R, Vasudevan DM. Hypolipidemic efficacy of Ocimum sanctum in the prevention of Atherogenesis in male albino rabbits. Pharmacologyonline, 2007; 2:115-117.
59. Khandelwal R, Nathani S. An ayurvedic approach to PCOS: A leading cause of female infertility. Int. J. Ayurveda Res., 2016; 1(3): 77-82.
60. Healthy living. Saraca asoca bark. Available from: https://healthyliving.natureloc.com/wp-content/uploads/2016/08/Ashoka-Bark4.jpg [Accessed January 12, 2021]
61. Etsystatic. Tinospora cordifolia. Available from: https://i.etsystatic.- com/11266331/r/il/660c45/2374644217/il_570xN.2374644217_- muzq.jpg [Accessed January 10, 2021]
62. Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac. J. Trop. Biomed., 2013: 3(5):337-352.
63. Sheeraz, M. Rational approach towards the role of kalawnji (nigella sativa linn) in marz-e– akyas khusyatur rehm (polycystic ovarian syndrome)-a review. Indo Am. J. Pharm., 2018; 8(5): 1089-1096.
64. Nafiu AB, Alimi S, Babalola A. Anti-androgenic and insulin-sensitizing actions of Nigella sativa oil improve polycystic ovary and associated dyslipidemia and redox disturbances. J. Complement. Med. Res, 2019; 10(4): 186-199.
65. Encyclopedia Britannica. Black cumin. Available from: https://www.britannica.com/plant/black-cumin [Accessed June 13, 2021]
66. Belwal T, Devkota HP, Singh MK, Sharma R. Chapter 3.40 - St. John’s Wort (Hypericumperforatum), nonvitamin and nonmineral. Nutritional Supplements; Academic Press, 2019; pp. 415-432.
67. Mitsi C, Efthimiou K. Infertility: Psychological-psychopathological consequences and cognitive-behavioural interventions]. Psychiatriki, 2014:25(4):293-302.
68. O’Reilly E, Sevigny M, Sabarre KA, Phillips KP. Perspectives of complementary and alternative medicine (CAM) practitioners in the support and treatment of infertility. BMC Complement. Altern. Med., 2014:14: 394.
69. Rayburn WF, Gonzalez CL, Christensen HD, Stewart JD. Effect of prenatally administered hypericum (St John’s wort) on growth and physical maturation of mouse offspring. Am. J. Obstet. Gynecol., 2001; 184(2): 191-195.
70. Canning S, Waterman M, Orsi N, Ayres J, Simpson N, Dye L. The efficacy of hypericumperforatum (st john’s wort) for the treatment of premenstrual syndrome: A randomized, doubleblind, placebo-controlled trial. CNS Drugs, 2010;24(3): 207-225.
71. Insulite health PCOS. Herbal remedies for PCOS. Available from: https://pcos.com/herbal-remedies/ [Accessed January 3, 2021]
72. Nariyal V, Sharma P. Kanchnar (Bauhinia variegata) as a medicinal herb: A systematic review. Int. J. Adv. Res. (Indore), 2017; 5(9): 587-591.
73. Netmeds. Kanchanar Guggulu: This ayurvedic formulation treats hormonal imbalance. Available from: https://www.netmeds.- com/health-library/post/kanchanar-guggulu-this-ayurvedic-formulation-treats-hormonal-imbalance [Accessed December 27, 2020]
74. Sudheerkumar K, Seetaramswamy S, Babu KA, Kumar PK. Phyto pharmacognostical and isolation of chemical constituents from bauhinia variegata leaf extract. J. Pharmacogn. Phytochem., 2015;(1): 189-191.
75. Farooq U, Khan S, Naz A, Khan A, Khan AA. Chinese Journal of Natural Medicine, 2017; 15(12): 9442017.
76. Fenkci V, Fenkci S, Yilmazer M, Serteser M. Fertility and Sterility, 2003;80(1):123
77. Gautam L, Shrestha s, Wagle P, Tamrakar B, Scientific World, 1970; 6(6): 2630
78. Irchhaiya R, Kumar A, Gurjar H, Gupta N, Kumar S, Kumar M. International Journal of Pharmacognosy, 2014;1(5):279
79. Kakadia N, Patel P, Deshpande S, Shah G. Journal of Traditional and Complementary Medicine, 2019;9(4):336.
80. Saiyed A, Jahan N, Makbul SAA, Ansari M, Bano H, Habib SH. Effect of combination of Withania somnifera Dunal and Tribulus terrestris Linn on letrozole induced polycystic ovarian syndrome in rats. Integr Med Res. 2016;5(4):293–300.
81. Bency Baby T, Smitha Rani, Remya K, Shebina Rasheed P, Azeem AK. Polycystic ovarian syndrome: Therapeutic potential of herbal remedies- A review. International Journal of Herbal Medicine. 2016; 4(5):91-96.
82. Shari Lieberman. A Review of the Effectiveness of Cimicifuga racemosa (Black Cohosh) for the Symptoms of Menopause. Journal of Women's Health. 2009; 7(5):525-529.
83. Gonzales GF, Cordova A, Vega K, Chung A, Villena A, Gonez C et al. Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. 2002; 34(6):367- 72.
84. Sharma Meenakshi, Sharma Gyan Prakash, Meena Mahendra Singh. Role of traditional ayurvedic herbs in gynocological disorders. A Demand of 21st Century. International Journal of Applied Ayurved Research. 2014; 1(8):2347-6362.
85. Grifola frondosa. https://en.wikipedia.org/.com.
86. Tori Hudson ND. Maitake Mushroom Extract and Polycystic Ovarian Syndrome. Natural Medicine Journal. 2011; 3(2):2157-6769.
87. Talpur N, Echard BW, Yasmin T. et al. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (–)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem 2003;252:369–377.
88. 10 home remedies for polycystic ovary syndrome. https://pcos.com/herbal-remedies/.
89. 5Ayurvedic Medicines for PCOS | PCOD- Poly Cystic Ovarian Syndrome & Disease. https://curaayurveda.wordpress.com. 12 April, 2014.
90. Kumar Santosh, Mehla RK, Dang AK. Use of shatavari (asparagus racemosus) as a galactopoietic and therapeutic herb-A review. Agric. Rev. 2008; 29(2):132- 138.
Published
2023-01-09
How to Cite
Kumar, V., & Kumar, N. (2023). Therapeutic Effect of Herbal Medicinal Plants on Polycystic Ovarian Syndrome: A Review. Asian Journal of Pharmaceutical Research and Development, 10(6), 153–160. https://doi.org/10.22270/ajprd.v10i6.1095
Issue
Section
Review Articles
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