In Vitro Formulation and Evaluation of Preparations Cefixime Nanosuspension

  • Armaliza Permata Sari Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam
  • Siska Esperanza Sinulingga Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam
  • Ahmad Syukur Hasibuan Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam

Abstract

Objective: To produce a nano-sized cefixime formulation and compare the cefixime formulation with the dissolution test of cefixime from nanosuspension.


Design: Nano-sized cefixime preparations were made with nanosuspension using ethanol and propylene glycol as a solvent and tween 80 as a surfactant. Then the nanosuspension and cefixime suspension were evaluated including organoleptic observations.


Interventions: The intervened variable were formulation an evaluation of cefixime nanosuspension


Main outcome measures: the main measurement in this study was dissolution of cefixime nanosuspension.


Results: The amount of soluble cefixime was measured by having a faster dissolution rate UV spectrophotometer at a wavelength of 285 nm. The average absorbance value of cefixime nanosuspension with propylene glycol solvent was 91.1192 ppm with a concentration of 1.05 nm, nanosuspension with ethanol solvent was 62.4998 ppm with a concentration of 0.72 nm


Conclusion: Nanosuspension with propylene glycol with a very fast dissolution rate. Cefixime can be formulated into nanosuspension preparations using ethanol or propylene glycol as solvent


 

Keywords: Cefixime, nanosuspension, dissolution

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Author Biographies

Armaliza Permata Sari, Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam

Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam

 

Siska Esperanza Sinulingga, Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam

Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam

Ahmad Syukur Hasibuan, Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam

Faculty of Pharmacy Institut Kesehatan Medistra Lubuk Pakam

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How to Cite
Sari, A., Sinulingga, S., & Hasibuan, A. ( ). In Vitro Formulation and Evaluation of Preparations Cefixime Nanosuspension. Asian Journal of Pharmaceutical Research and Development, 9(6), 62-64. https://doi.org/https://doi.org/10.22270/ajprd.v9i6.1043