Nanofibers in Drug Delivery System
DOI:
https://doi.org/10.22270/ajprd.v9i4.1011Keywords:
Electrospinning, Nanofibers, Sources of nanofiber, Drug delivery system, Applications of nanofibers.Abstract
The possible applications of electrospun fibers in drug delivery systems (DDS) are critically examined in this study. Nanofibers are among the most desirable resources in some kind of a variety of scenarios due to their operational capabilities including valuable features for another young generation of resources in energy, climate, even wellness. Because of its possibility to synthesize polymers with specific functions like greater porous design electrospinning was already presented as the most effective technique for fabricating polymer-based nanostructures. Electrospinning has emerged with the most significant challenge for fabricating nanostructures with several advantageous properties which are helpful in a wide range of uses first from the atmosphere to biomedicine. The medicine delivering mechanisms depending upon nanofibers have made significant progress in terms of regulated and sustained release. This analysis summarizes significant advancements within the production of electrospun nanofibers-based rapidly dispersing dosage form using many fibers, therapeutic agents, including entrapment approaches, as an emphasis on mouth administration. The oral cavity became the most discussed mucous membrane location because it would be open or even simple to examine, whereas the others are difficult for the patient and difficult to determine in vivo, according to this study. The drug-loaded nanofibrous structures are described based on their main functions and also the areas for operation.
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References
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2. Sousa MG, Maximiano MR, Costa RA, Rezende TM, Franco OL. Nanofibers as drug-delivery systems for infection control in dentistry. Expert opinion on drug delivery. 2020; 17(7):919-30
3. Nandi SK, Mahato A, Kundu B, Mukherjee P. Organic–inorganic micro/nanofiber composites for biomedical applications. InMaterials for Biomedical Engineering 2019 Jan 1 (pp. 21-55). Elsevier.
4. Beachley V, Wen X. Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions. Progress in polymer science. 2010 Jul 1; 35(7):868-92.
5. Bottino MC, Kamocki K, Yassen GH, Platt JA, Vail MM, Ehrlich Y, Spolnik KJ, Gregory RL. Bioactive nanofibrous scaffolds for regenerative endodontics. Journal of dental research. 2013 Nov; 92(11):963-9.
6. Wang L, Hu C, Shao L. The antimicrobial activity of nanoparticles: present situation and prospects for the future. International journal of nanomedicine. 2017; 12:1227.
7. Sasikala AR, Unnithan AR, Park CH, Kim CS. Nanofiber-based anticancer drug delivery platform. In Biomimetic nanoengineered materials for advanced drug delivery 2019 Jan 1 (pp. 11-36). Elsevier.
8. Alghoraibi I, Alomari S. Different methods for nanofiber design and fabrication. Handbook of nanofibers. 2018:1-46.
9. Pant B, Park M, Park SJ. Drug delivery applications of core-sheath nanofibers prepared by coaxial electrospinning: a review. Pharmaceutics. 2019 Jul;11(7):305.
10. Kurian S, Amrita C, Raguram T, Rajni KS. Preparation and Characterisation of PVA+ TiO2 Nanofiber by Electrospinning Technique. InIOP Conference Series: Materials Science and Engineering 2019 Nov 1 (Vol. 577, No. 1, p. 012077). IOP Publishing.
11. Xue J, Wu T, Dai Y, Xia Y. Electrospinning and electrospun nanofibers: Methods, materials, and applications. Chemical reviews. 2019 Mar 27; 119(8):5298-415.
12. Parwe SP, Chaudhari PN, Mohite KK, Selukar BS, Nande SS, Garnaik B. Synthesis of ciprofloxacin-conjugated poly (L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation. International journal of nanomedicine. 2014; 9:1463.
13. Goyal R, Macri LK, Kaplan HM, Kohn J. Nanoparticles and nanofibers for topical drug delivery. Journal of Controlled Release. 2016 Oct 28;240:77-92.
14. Ji W, Sun Y, Yang F, van den Beucken JJ, Fan M, Chen Z, Jansen JA. Bioactive electrospun scaffolds delivering growth factors and genes for tissue engineering applications. Pharmaceutical research. 2011 Jun; 28(6):1259-72.
15. Sun Z, Zussman E, Yarin AL, Wendorff JH, Greiner A. Compound core–shell polymer nanofibers by co‐electrospinning. Advanced materials. 2003 Nov 17; 15(22):1929-32.
16. Chakraborty S, Liao IC, Adler A, Leong KW. Electrohydrodynamics: a facile technique to fabricate drug delivery systems. Advanced drug delivery reviews. 2009 Oct 5;61(12):1043-54.
17. Puls J, Wilson SA, Hölter D. Degradation of cellulose acetate-based materials: a review. Journal of Polymers and the Environment. 2011 Mar 1;19(1):152-65.
18. Mostafa NA, Farag AA, Abo-dief HM, Tayeb AM. Production of biodegradable plastic from agricultural wastes. Arabian journal of chemistry. 2018 May 1; 11(4):546-53.
19. Wsoo MA, Shahir S, Bohari SP, Nayan NH, Abd Razak SI. A review on the properties of electrospun cellulose acetate and its application in drug delivery systems: A new perspective. Carbohydrate research. 2020 May 1; 491:107978.
20. Wan Y, Lin Z, Gan D, Cui T, Wan M, Yao F, Zhang Q, Luo H. Effect of graphene oxide incorporation into electrospun cellulose acetate scaffolds on breast cancer cell culture. Fibers and Polymers. 2019 Aug; 20(8):1577-85.
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23. Zahedi P, Rezaeian I, Ranaei‐Siadat SO, Jafari SH, Supaphol P. A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polymers for Advanced Technologies. 2010 Feb; 21(2):77-95.
24. Chaushu L, Weinreb M, Beitlitum I, Moses O, Nemcovsky CE. Evaluation of a topical herbal patch for soft tissue wound healing: an animal study. Journal of clinical periodontology. 2015 Mar; 42(3):288-93.
25. Norouzi M, Shabani I, Ahvaz HH, Soleimani M. PLGA/gelatin hybrid nanofibrous scaffolds encapsulating EGF for skin regeneration. Journal of Biomedical Materials Research Part A. 2015 Jul; 103(7):2225-35.
26. Mele E. Electrospinning of natural polymers for advanced wound care: towards responsive and adaptive dressings. Journal of Materials Chemistry B. 2016; 4(28):4801-12.
27. Liu M, Duan XP, Li YM, Yang DP, Long YZ. Electrospun nanofibers for wound healing. Materials Science and Engineering: C. 2017 Jul 1;76:1413-23.
28. Dai T, Tanaka M, Huang YY, Hamblin MR. Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects. Expert review of anti-infective therapy. 2011 Jul 1; 9(7):857-79.
29. Jean M, Smaoui F, Lavertu M, Methot S, Bouhdoud L, Buschmann MD, Merzouki A. Chitosan–plasmid nanoparticle formulations for IM and SC delivery of recombinant FGF-2 and PDGF-BB or generation of antibodies. Gene therapy. 2009 Sep; 16(9):1097-110.
30. Sajkiewicz P, Kołbuk D. Electrospinning of gelatin for tissue engineering–molecular conformation as one of the overlooked problems. Journal of Biomaterials Science, Polymer Edition. 2014 Dec 12; 25(18):2009-22.
31. Haugh MG, Murphy CM, McKiernan RC, Altenbuchner C, O'Brien FJ. Crosslinking and mechanical properties significantly influence cell attachment, proliferation, and migration within collagen glycosaminoglycan scaffolds. Tissue Engineering Part A. 2011 May 1; 17(9-10):1201-8.
32. Augst AD, Kong HJ, Mooney DJ. Alginate hydrogels as biomaterials. Macromolecular bioscience. 2006 Aug 7; 6(8):623-33.Rowley JA, Madlambayan G, Mooney DJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials. 1999 Jan 1; 20(1):45-53.
33. Khil MS, Cha DI, Kim HY, Kim IS, Bhattarai N. Electrospun nanofibrous polyurethane membrane as wound dressing. Journal of Biomedical Materials Research Part B: Applied Biomaterials: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials. 2003 Nov 15; 67(2):675-9.
34. Sharma R, Singh H, Joshi M, Sharma A, Garg T, Goyal AK, Rath G. Recent advances in polymeric electrospun nanofibers for drug delivery. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2014; 31(3).
35. Mkhabela VJ, Ray SS. Poly (ε-caprolactone) nanocomposite scaffolds for tissue engineering: a brief overview. Journal of nanoscience and nanotechnology. 2014 Jan 1; 14(1):535-45.
36. Schnell E, Klinkhammer K, Balzer S, Brook G, Klee D, Dalton P, Mey J. Guidance of glial cell migration and axonal growth on electrospun nanofibers of poly-ε-caprolactone and a collagen/poly-ε-caprolactone blend. Biomaterials. 2007 Jul 1; 28(19):3012-25.
37. Li M, Mondrinos MJ, Chen X, Gandhi MR, Ko FK, Lelkes PI. Co‐electrospun poly (lactide‐co‐glycolide), gelatin, and elastin blends for tissue engineering scaffolds. Journal of Biomedical Materials Research Part A. 2006 Dec 15; 79(4):963-73.
38. Ma Z, He W, Yong T, Ramakrishna S. Grafting of gelatin on electrospun poly (caprolactone) nanofibers to improve endothelial cell spreading and proliferation and to control cell orientation. Tissue engineering. 2005 Jul 1; 11(7-8):1149-58.
39. Wang X, Li Q, Hu X, Ma L, You C, Zheng Y, Sun H, Han C, Gao C. Fabrication and characterization of poly (l-lactide-co-glycolide) knitted mesh-reinforced collagen–chitosan hybrid scaffolds for dermal tissue engineering. Journal of the mechanical behavior of biomedical materials. 2012 Apr 1; 8:204-15.
40. Yuan Z, Zhao J, Yang Z, Wang X, Zheng Q, Cui W. Integrated therapy on residual tumor after palliative operation using dual-phase drug releasing electrospun fibrous scaffolds. Journal of controlled release: official journal of the Controlled Release Society. 2015 Sep 10;213:e151-2.
41. Zhao J, Liu S, Li B, Yang H, Fan C, Cui W. Stable Acid‐R esponsive Electrospun Biodegradable Fibers as Drug Carriers and Cell Scaffolds. Macromolecular bioscience. 2013 Jul; 13(7):885-92.
42. Khodadadi M, Alijani S, Montazeri M, Esmaeilizadeh N, Sadeghi‐Soureh S, Pilehvar‐Soltanahmadi Y. Recent advances in electrospun nanofiber‐mediated drug delivery strategies for localized cancer chemotherapy. Journal of Biomedical Materials Research Part A. 2020 Jul;108(7):1444-58.
43. Ramachandran R, Junnuthula VR, Gowd GS, Ashokan A, Thomas J, Peethambaran R, Thomas A, Unni AK, Panikar D, Nair SV, Koyakutty M. Theranostic 3-Dimensional nano brain-implant for prolonged and localized treatment of recurrent glioma. Scientific reports. 2017 Mar 6; 7(1):1-6.
44. Yildiz ZI, Celebioglu A, Uyar T. Polymer-free electrospun nanofibers from sulfobutyl ether7-beta-cyclodextrin (SBE7-β-CD) inclusion complex with sulfisoxazole: Fast-dissolving and enhanced water-solubility of sulfisoxazole. International journal of pharmaceutics. 2017 Oct 15;531(2):550-8.
45. Domokos A, Balogh A, Dénes D, Nyerges G, Ződi L, Farkas B, Marosi G, Nagy ZK. Continuous manufacturing of orally dissolving webs containing a poorly soluble drug via electrospinning. European Journal of Pharmaceutical Sciences. 2019 Mar 15; 130:91-9.
46. Zupančič Š, Preem L, Kristl J, Putrinš M, Tenson T, Kocbek P, Kogermann K. Impact of PCL nanofiber mat structural properties on hydrophilic drug release and antibacterial activity on periodontal pathogens. European Journal of Pharmaceutical Sciences. 2018 Sep 15; 122:347-58.
47. Liu ZP, Zhang LL, Yang YY, Wu D, Jiang G, Yu DG. Preparing composite nanoparticles for immediate drug release by modifying electrohydrodynamic interfaces during electrospraying. Powder Technology. 2018 Mar 1; 327:179-87.
48. Li X, Kanjwal MA, Lin L, Chronakis IS. Electrospun polyvinyl-alcohol nanofibers as oral fast-dissolving delivery system of caffeine and riboflavin. Colloids and Surfaces B: Biointerfaces. 2013 Mar 1; 103:182-8.
49. Ghorani B, Tucker N. Fundamentals of electrospinning as a novel delivery vehicle for bioactive compounds in food nanotechnology. Food Hydrocolloids. 2015 Oct 1; 51:227-40.
50. Koosha M, Mirzadeh H. Electrospinning, mechanical properties, and cell behavior study of chitosan/PVA nanofibers. Journal of Biomedical Materials Research Part A. 2015 Sep; 103(9):3081-93.
51. Morales JO, McConville JT. Manufacture and characterization of mucoadhesive buccal films. European Journal of Pharmaceutics and Biopharmaceutics. 2011 Feb 1; 77(2):187-99.
52. Nagy ZK, Balogh A, Démuth B, Pataki H, Vigh T, Szabó B, Molnár K, Schmidt BT, Horák P, Marosi G, Verreck G. High speed electrospinning for scaled-up production of amorphous solid dispersion of itraconazole. International journal of pharmaceutics. 2015 Mar 1; 480(1-2):137-42.
53. Pitts NB, Zero DT, Marsh PD, Ekstrand K, Weintraub JA, Ramos-Gomez F, Tagami J, Twetman S, Tsakos G, Ismail A. Dental caries. Nature reviews Disease primers. 2017 May 25; 3(1):1-6.
54. Frencken JE, Sharma P, Stenhouse L, Green D, Laverty D, Dietrich T. Global epidemiology of dental caries and severe periodontitis–a comprehensive review. Journal of clinical periodontology. 2017 Mar; 44:S94-105.
55. Cheng L, Zhang K, Weir MD, Melo MA, Zhou X, Xu HH. Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries. Nanomedicine. 2015 Mar; 10(4):627-41.
56. Samprasit W, Kaomongkolgit R, Sukma M, Rojanarata T, Ngawhirunpat T, Opanasopit P. Mucoadhesive electrospun chitosan-based nanofibre mats for dental caries prevention. Carbohydrate polymers. 2015 Mar 6; 117:933-40.
57. Wright ME, Wong AT, Levitt D, Parrag IC, Yang M, Santerre JP. Influence of ciprofloxacin‐based additives on the hydrolysis of nanofiber polyurethane membranes. Journal of Biomedical Materials Research Part A. 2018 May; 106(5):1211-22.
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Published
2021-08-15
How to Cite
Dawange, S. R., Boraste, S. S., Pingale, P. L., & Amrutkar, S. V. (2021). Nanofibers in Drug Delivery System. Asian Journal of Pharmaceutical Research and Development, 9(4), 151–157. https://doi.org/10.22270/ajprd.v9i4.1011
Issue
Section
Review Articles
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