Asian Journal of Pharmaceutical Research and Development 2022-08-18T10:33:24+0530 Prof. (Dr.) M. P. Khinchi Open Journal Systems <div class="aboutushome" align="justify"><strong>Asian Journal of Pharmaceutical Research and Development (AJPRD)</strong>&nbsp;is a new online international journal allowing free unlimited access to abstract and Full text. The journal is devoted to the promotion of pharmaceutical sciences and related disciplines. It seeks particularly (but not exclusively) to encourage pharmaceutical and allied research of tropical relevance and to foster multidisciplinary research and collaboration among scientists, the pharmaceutical industry and health the health care professionals. It will also provide an international plate form for the communication and evaluation of data, methods and findings in pharmaceutical sciences and related disciplines. Although primarily devoted to original research papers, the journal welcomes reviews on current topics of special interest and relevance.</div> <div class="aboutushome">&nbsp;</div> Potential Interactions of Hypertension Drug in Medan City Pharmacy 2022-08-15T14:18:31+0530 Sri Wahyuni Kiki Rawitri Yayuk Putri Rahayu <p><strong>Background:</strong> Hypertension is a disease that can cause complications without the patient realizing it. Therapeutic management needed to control the patient's blood pressure is complex enough to potentially lead to drug interactions. The purpose of this study was to analyze the interaction of hypertension drugs that occurred in a pharmacy in the city of Medan.</p> <p><strong>Method</strong>: The study was conducted retrospectively involving 101 patient data in February-May 2022. Patient data was processed descriptively and potential drug interactions were analyzed using the Medscape Drug Interactions Checker, Stockley's Drug Interaction, and the database</p> <p><strong>Result: </strong>Based on the study results, it was found that from 101 patients, 57 patients had no drug interactions (56.4%), but 45 cases of drug interactions were found in 44 patients (43.6%). Drug interactions found in 27 cases occurred pharmacokinetically (60%) and 18 cases occurred pharmacodynamically (40%). The most frequent drug interactions are Amlodipine and Simvastatin.</p> <p><strong>Conclusion</strong>: Based on this study, it can be concluded that most patients who have drug interactions occur through pharmacokinetic mechanisms.</p> <p>&nbsp;</p> 2022-08-13T11:44:22+0530 ##submission.copyrightStatement## The effect of tooth brushing counseling on increasing knowledge of dental and oral health of physical education teachers 2022-08-15T14:18:31+0530 Wiworo Haryani Shanti Yolanda Putri Aryani Widayati <p>Background: Dental and oral health requires comprehensive handling. Prevention of dental and oral diseases can be done by providing dental health education from an early age, counseling is very effective in improving the level of dental and oral health. Purpose: To determine the effect of brushing counseling on dental and oral health knowledge of elementary physical education teachers in Padang Panjang. Methods: This type of research is a quasi-experimental research with a total sampling technique with a total population of 42 physical education teachers, 21 people are included in the experimental group, namely the group that is given counseling and 21 others are included in the control group, namely the group that is given counseling using leaflet media. This study uses the Wilcoxon Signed Ranks Test hypothesis test. Results: The level of knowledge of dental and oral health before counseling was 33.3% in good criteria, 47.6% enough and 19.0% less and after counseling it became a good category that is, 90.5%, enough 9.5% and less as much as 0 %. The Wilcoxon Signed Ranks Test results showed significant value of 0.000 and 0.000 &lt;0.05. Conclusion: Counseling teeth brushing an effects on increasing knowledge of oral and dental health on physical education teachers</p> <p>&nbsp;</p> <table> <tbody> <tr> <td width="69">&nbsp;</td> </tr> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> </tbody> </table> 2022-08-13T12:11:05+0530 ##submission.copyrightStatement## Educational Model: Anti-Stroke Gymnastics on Compliance and Health Status of Patients Hypertension 2022-08-15T14:18:31+0530 Santa Manurung <p>Background: The prevalence of hypertension continues to increase, various epidemiological studies show an increase in the incidence and prevalence of hypertension in various parts of the world. According to the American Heart Association (AHA), the American population aged over 20 years suffering from hypertension has reached up to 74.5 million people, but almost 90% of cases have no known cause. Hypertension is a silent killer where the symptoms can vary in each individual and are almost the same as the symptoms of other diseases. In Indonesia, the problem of hypertension is a big challenge, because hypertension is very often found in primary health services with a high prevalence. Hypertension if not handled properly can cause damage to blood vessels throughout the body and the most obvious is the risk of damage to the brain, eyes, heart, and kidney disease. These risks can be avoided and minimized by pharmacological and non-pharmacological management. Anti-stroke exercise is one of the gymnasticsthat is useful to prevent the risk of stroke in someone who suffers from hypertension. This research is a quasi experiment with pre-post test with control group design. This study aims to determine the effect of anti-stroke gymnastics education on adherence and health status of patients with hypertension. The sampling technique was simple random sampling and the determination of the sample size was using the hypothesis test of the average difference in two independent groups. Data processing and analysis in this study used paired t-test and independent t-test. The results showed that there were significant differences in knowledge, patient compliance, decreased blood pressure and health status of hypertension patients after anti-stroke gymnastics was performed. It is recommended that anti-stroke gymnastics can be used as a non-pharmacological therapy to treat hypertension patients to prevent stroke.</p> <table> <tbody> <tr> <td width="69">&nbsp;</td> </tr> <tr> <td>&nbsp;</td> <td>&nbsp;</td> </tr> </tbody> </table> 2022-08-13T12:16:10+0530 ##submission.copyrightStatement## Micropropagation of Pogostemon paniculatus 2022-08-15T14:18:31+0530 Manoj Godbole Vanya K N Lenifer H D Amrutha Y Shruthi K Sujay K S <p>Plant regeneration potential from node &amp; leaf explants of <em>Pogostemon paniculatus</em> through direct shoot proliferation was studied on Murashige and Skoog medium supplemented with various concentrations of cytokinins &amp; auxins<em>. </em>As the seed germinability of the plant is low <em>in vitro</em>, we have tried these explants for micropropagation. Among different concentrations of individual hormones tested for nodal explants, benzylaminopurine (BAP) at 5µM &amp; kinetin (Kn) at 0.5µM showed 4 &amp; 2 mean number of shoots/explant respectively &amp; combination of Kn (0.5 µM)&nbsp; + BAP (1.5 µM) showed 15 mean number of shoots/explant. For leaf explant combination of Kn (0.5 µM) + BAP (1.5 µM) showed 20 mean number of shoots/explant. Other hormones tested at all concentrations showed callus formation without the shoot development. Roots were established on the isolated shoots on naphthaleneacetic acid (NAA) at 0.25µM. Rooted plants were acclimatized. This is the first report of <em>Pogostemon paniculatus</em> micropropagation.</p> <p><strong>&nbsp;</strong></p> 2022-08-13T12:22:34+0530 ##submission.copyrightStatement## Simultaneous Estimation of Metoprolol and Telmisartan in Combined Tablet Dosage Form by Using RP-HPLC and UV Spectrophotometry 2022-08-15T14:18:31+0530 Sravanthi Gandu Parameshwari . Ravinder M Kumaraswamy Gandla Gade Narmada <p>An accurate, precise and reproducible RP-HPLC and UV Spectrophotometric method was developed and validated for the simultaneous estimation of Metoprolol and Telmisartan in tablet dosage form. The chromatographic separation was carried out on X-tera C<sub>8</sub> column (100mm*4.6mm*5µ), by using the mobile phase (0.05M Sodium phosphate buffer pH 2.8 and methanol) in the ratio 35:65, at a flow rate 1.2ml/min. The detection was carried out at a wave length of 226nm. The retention time for Metoprolol and Telmisartan was found to be 2.338 and 5.559 respectively. UV method involves solving simultaneous equations based on measurement of absorbance at two wavelengths 223nm and 296nm λmax of Metoprolol and&nbsp; Telmisartan respectively. Beer’s law was obeyed in the concentration range of 1.25-6.25μg/ml and 2-10μg/ml for Metoprolol and Telmisartan respectively. The developed methods were validated according to ICH guidelines.</p> <p>&nbsp;</p> 2022-08-13T12:27:16+0530 ##submission.copyrightStatement## Formulation Development and Evaluation of Mucoadhesive Buccal Tablets of Acebutolol Hydrochloride 2022-08-18T09:35:10+0530 Priyanka Dilip Chaudhari Amol Bhalchandra Deore Manoj Jagannath Jagtap Devanshi Sunil Gupta <p>A mucoadhesive drug delivery system is an oral dosage form, where the tablet, gel, or patch is attached to the buccal region for direct absorption of the drug into blood circulation. This dosage form has been employed to improve the bioavailability of drugs that undergoes significant hepatic first-pass metabolism. Acebutolol is a beta sympatholytic agent used to treat high blood pressure and irregular heartbeat (arrhythmia). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. In present investigation, mucoadhesive buccal tablets of acebutolol HCl were prepared using carbopol 940 in varying concentrations with secondary polymer xanthan gum by direct compression method. Nine batches were prepared as per 3<sup>2</sup> factorial designs, to investigate the combined effects of independent variables namely carbopol 940 and xanthan gum on dependant variables namely swelling index, mucoadhesion strength and in-vitro drug release using design expert software version Preformulation studies confirmed the identity and purity of the drug by means of UV spectroscopy, IR spectroscopy, DSC analysis, and melting point determination. The tablets were evaluated for hardness, thickness, weight variation, friability, and drug content concluded that all these parameters were in an acceptable range of pharmacopoeial specification. The buccal tablets were studied for surface pH, swelling index, in vitro drug release study, adhesion force, in vitro mucoadhesive strength, stability, and compatibility study to optimise the formula. Amongst all factorial batches (F1 to F9), batch F5 (30 mg carbopol 940 and 30 mg xanthan gum) showed maximum drug release of 99.96 % after 12 hr of study and also showed better contact with biological membrane. The drug release kinetics of batch F5 was found to be best fitted to zero order kinetic model and exhibited anomalous diffusion release mechanism. The formulation F5 exhibited good correlation (R2=0.992) for in-vitro drug release. All the evaluation parameters give positive results and comply with the standards. Stability studies were carried out on the developed formulations indicating that the formulations were stable during the period of 6 months. In conclusion, the formulation F5 is stable and effective for quick action and seems to be alternative to the conventional tablet.</p> <p><strong>&nbsp;</strong></p> 2022-08-13T13:11:32+0530 ##submission.copyrightStatement## Neuroprotective Effect of Withania Somnifera Root Extract In Type 2 Diabetes Mellitus Induced Cognitive Impairment And Neurodegeneration In Rats 2022-08-15T14:18:31+0530 Anshul Tanwar Kavita Gulati Arunabha Ray <p>The present study was conducted to assess the effects of <em>Withania somnifera</em> root extract (WS) on cognitive deficit and neurodegeneration induced by type 2 diabetes mellitus in rats. Type 2 diabetes mellitus (T2DM) was induced in rats by feeding them high fat diet (HFD) for 8 weeks followed by intraperitoneal administration of low dose Streptozotocin (STZ; 35 mg/kg). After four weeks of STZ administration the levels of metabolic parameters (fasting blood glucose, serum triglycerides and serum total cholesterol) were measured to confirm the development of diabetes. WS and Pioglitazone (PZ) were administered daily for 8 weeks to the diabetic rats. At the end of the treatment, behavioural analysis was done to observe the effects of diabetes on memory by Morris water maze (MWM) test. Thereafter, animals were sacrificed; blood and brain samples were collected for biochemical analysis. Metabolic parameters (fasting blood glucose, serum triglycerides and total cholesterol) were found to be significantly elevated in diabetic rats as compared to normal control animals; treatment with WS and PZ for 8 weeks significantly lowered these levels. In MWM test, mean escape latency time (ELT) on day 4 was found to be increased and time spent in the target quadrant (TSTQ) on day 5 was reduced significantly in DC rats as compared to NC. However, TSTQ increased significantly and mean ELT was found to be decreased in the rats treated with WS at the dose of 100 and 300 mg/kg for 8 weeks as compared to DC rats. The level of Aβ1-42, a main component of amyloid plaques, was found to be increased significantly in hippocampus and prefrontal cortex of DC rats as compared to NC and treatment with WS lowered the levels of Aβ1-42. Further, the level of brain-derived neurotrophic factor (BDNF) was found to be reduced significantly in diabetic rats whereas WS treated groups showed a significant increase in BDNF. The data suggests that treatment with standardized root extract of <em>Withania somnifera</em> normalized the elevated metabolic parameters in diabetic animals when compared with untreated diabetic animals and the results were comparable with pioglitazone. Also it was found that T2DM adversely affects memory and cause neurodegeneration. WS treatment showed neuroprotective effects and improved memory retention in diabetic animals. Thus root extract of<em> Withania Somnifera</em> may have neuroprotective effects for the management of T2DM induced cognitive deficit.</p> <p>&nbsp;</p> 2022-08-13T22:17:51+0530 ##submission.copyrightStatement## Anti Inflammatory and Antioxidant Activity of Ziziphus Jujuba Extract 2022-08-18T10:33:24+0530 Bhawana Singh Sandra Gautam B K Dubey Deepak Kumar Basedia <p>The antioxidant activity of the leaves and fruits of <em>Ziziphus jujuba</em> and contribution in some phytochemical characteristics was obtained. Phytochemical analysis was found that <em>Ziziphus jujuba </em>leaves and Fruits were loss on drying 0.85%, 0.65%, total ash values were 5.3%, 7.6% , Acid insoluble ash value were 2.9%, 4.4%, Water soluble ash value were 0.7%, 1.1% and Foaming index were 13ml, 12ml. Phytochemical screening was found that carbohydrate present in JFE and JFA, alkaloids were present in JLE, JLA and JFE, glycosides were present in JFA, flavonoids were present in all type of extracts, steroids were present in only JLE and protein and amino acids were present in JFE and JFA. JFE possessed higher antioxidant activity with IC<sub>50 </sub>value of &lt; 300 µg/ml among all extracts for both methods and higher inhibition found in DPPH method 96.32% and in ABTS method&nbsp; it is 98.68 %. &nbsp;Aqueous extract of <em>Ziziphus Jujuba</em> fruit (JFA) was exhibited excellent anti-inflammatory activity against COX-1 &amp; Cox-2 with IC<sub>50</sub> value less than &lt;0.2mg/ml.&nbsp; Ethanolic extract of leaf (JLE) &amp; Ethanolic extract of fruit (JFE) possessed moderate activity (&lt; 0.3) against both COX-1 &amp; Cox-2.&nbsp; Aqueous extract of leaf (JLA) exhibited poor activity against both COX-1 &amp; Cox-2. Overall conclusion of anti-inflammatory study of different extracts of <em>Ziziphus Jujuba</em> leaves and fruit were possessed anti inflammatory activity and inhibition was increased with concentration of samples increased.&nbsp;&nbsp;</p> <p>&nbsp;</p> 2022-08-18T10:33:24+0530 ##submission.copyrightStatement## Review: Phytochemical of Some Plants with Anticoagulant 2022-08-15T14:18:32+0530 Meisy Sitiawani Zikra Azizah Ridho Asra Boy Chandra <p><strong>Background: </strong>Anticoagulants are drugs used to treat hypertension and cardiovascular disease.This review article aims to discuss several types of natural plants with anticoagulant activity.</p> <p><strong>Materials and Methods</strong>: The method used is the study of relevant literature(national and international journals) which is accessed through online sites such as Google Scholar, Research Gate, Science Direct, Springer Link, and NCBI, published in the last 10 years (2011-2021) with the keyword “herbal plant” or “medicinal plant” and “anticoagulant” and “cardiovascular”.</p> <p><strong>Results: </strong>Based on in vitro and in vivo tests, some plants such as Allium sativum L., Averrhoa bilimbi, Persea americana Mill., Tridax procumbens L., Carica papaya L., Rhizophora sp, Syzygiumcumini L., Piper batle L., Erigeron canadensis L., Ainsliaea fragrans, Averrhoa bilimbi, Carica papaya L., are types of plants with anticoagulant activity.</p> <p><strong>Conclusion: </strong>Herb can be used as alternative sources of new anticoagulant agents cause of their biological activity. The use of medicinal plants with therapeutic effects and minimal side effects can be the best choice for the prevention and treatment of various diseases including cardiovascular disorders.</p> <p>&nbsp;</p> 2022-08-14T22:08:56+0530 ##submission.copyrightStatement## Review: Drug Discovery and Development of Warfarin 2022-08-15T14:18:32+0530 Tirsa Ami Manao Ridho Asra Boy Chandra <p><strong>Background</strong>: The history of the discovery of Warfarin started from the plains of North America in Canada in 1920. Livestock in that area died from bleeding. Warfarin was first used in 1948 as a rodenticide, and in 1954 the US Food and Drug Administration (FDA) approved it for medical use as an anticoagulant.</p> <p><strong>Purpose: </strong>This review article aims to discuss the history of the discovery of warfarin starting from the presence of blood clotting disorders to the point that researchers worked to find drugs that can inhibit blood clotting, namely the anticoagulant group.</p> <p><strong>Research Methods: </strong>The method used is the study of relevant literature which is accessed through online sites such as Google Scholar, Research Gate, Science Direct, Springer Link, and NCBI.</p> <p><strong>Conclusion</strong>: In its development, several trials such as in silico, preclinical, and clinical trials have shown significant results but are always associated with bleeding.</p> <p><strong>&nbsp;</strong></p> 2022-08-14T22:11:53+0530 ##submission.copyrightStatement## Review of Active Compounds from Medicinal Plants with Antihyperglycemic Efficiency on Translocation and Expression of Glucose Transporter 4 on Muscle and Adipose Tissue 2022-08-15T14:18:32+0530 Jena Hayu Widyasti Fitri Kurniasari Rahmat Budi Nugroho <p>Glucose transporter’s mechanism is influenced by the presence of insulin, especially GLUT4 which acts on muscle, adipose, and brain tissue. Medicinal plants with active compounds that were able to regulate the expression and translocation of GLUT helps in the treatment of insulin resistance and hyperglycemia. This study aimed to determine which active compounds isolated from medicinal plants have antihyperglycemic activity on GLUT4 expression in muscle and adipose tissue. The research method used was by searching the literature electronically with the keywords "Plant Isolation", "Chemical Compounds", "Antihyperglycemic Activity", and "Glucose transporter (GLUT) 4". Literature sources in the form of international and national journals have been found on several sites, such as NCBI, Elsevier and Pubmed, and others. A literature search in the form of selected journals from 2016 to 2021. The data were analyzed using the PRISMA (Prefered Reporting Items for Systematic Review and Meta-analyses) method. The results showed that the active substances contained in the plant have antihyperglycemic activity by increasing the translocation and expression of GLUT4 in skeletal muscle cells, adipocytes, and tested-animal models of DM.</p> <p>&nbsp;</p> 2022-08-14T22:13:28+0530 ##submission.copyrightStatement## Medicinal Plant Used Against Cancer: A Review 2022-08-15T14:18:32+0530 Rajat Srivastava Priya Tiwari <p>Nowadays natural products are considered protective markers compared to synthetic products that are considered unsafe for human health and the environment. Although a large number of synthetic drugs have been added to the world of current pharmacopoeia, there is still no drug system in the world that has been able to solve all health problems, including diseases such as Cancer. The extracts from plants have played an important role in the development of clinically effective anti-cancer agents. The plant kingdom produces naturally occurring secondary metabolites that are being investigated for their anti-cancer activities leading to the development of new clinical drugs. Global results continue to identify new anticancer compounds from plants. In recent years out of fear of adverse effects, people have chosen to make greater use of natural cancer products. This review attempted to summarize a few plants in India and outside India that have anti-cancer activity.</p> <p><strong>&nbsp;</strong></p> 2022-08-14T22:23:43+0530 ##submission.copyrightStatement## A Review on Simultaneous Determination of Anti-Hypertensive Drug Combinations Containing Amlodipine Besylate using Chromatographic Analysis 2022-08-18T06:56:58+0530 Sajith Kumar Chandran <p><span id="page3R_mcid37" class="markedContent"><span dir="ltr" style="left: 94.4px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.14155);" role="presentation">The</span> <span dir="ltr" style="left: 128.771px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.13651);" role="presentation">present</span> <span dir="ltr" style="left: 187.919px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.17767);" role="presentation">review</span> <span dir="ltr" style="left: 239.267px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.11316);" role="presentation">aims</span> <span dir="ltr" style="left: 280.861px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.13656);" role="presentation">to</span> <span dir="ltr" style="left: 303.641px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.1401);" role="presentation">investigate</span> <span dir="ltr" style="left: 383.612px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.05441);" role="presentation">some</span> <span dir="ltr" style="left: 427.779px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.18724);" role="presentation">of</span> <span dir="ltr" style="left: 449.942px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.14272);" role="presentation">the</span> <span dir="ltr" style="left: 480.936px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.12269);" role="presentation">recently</span> <span dir="ltr" style="left: 542.911px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.16295);" role="presentation">reported</span> <span dir="ltr" style="left: 607.848px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.14899);" role="presentation">analytical</span> <span dir="ltr" style="left: 681.441px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.11863);" role="presentation">methods</span> <span dir="ltr" style="left: 747.797px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.16607);" role="presentation">available</span> <span dir="ltr" style="left: 815.36px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.26247);" role="presentation">for</span> <span dir="ltr" style="left: 843.326px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.14272);" role="presentation">the</span> <span dir="ltr" style="left: 874.293px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.0452);" role="presentation">assay</span> <span dir="ltr" style="left: 921.26px; top: 499.718px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.16848);" role="presentation">of</span></span><span id="page3R_mcid38" class="markedContent"><br role="presentation"><span dir="ltr" style="left: 94.4px; top: 515.318px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.19153);" role="presentation">antihypertensive drugs in various</span></span><span id="page3R_mcid39" class="markedContent"> <span dir="ltr" style="left: 322.833px; top: 515.318px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.14474);" role="presentation">combinations</span></span><span id="page3R_mcid40" class="markedContent"></span><span id="page3R_mcid41" class="markedContent"> <span dir="ltr" style="left: 416.283px; top: 515.318px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.1888);" role="presentation">of</span></span><span id="page3R_mcid42" class="markedContent"></span><span id="page3R_mcid43" class="markedContent"> <span dir="ltr" style="left: 433.483px; top: 515.318px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.1493);" role="presentation">pharmaceutical forms. Several simultaneous RP</span></span><span id="page3R_mcid44" class="markedContent"><span dir="ltr" style="left: 751.917px; top: 515.318px; font-size: 13.4px; font-family: sans-serif;" role="presentation">-</span></span><span id="page3R_mcid45" class="markedContent"></span><span id="page3R_mcid46" class="markedContent"> <span dir="ltr" style="left: 762.767px; top: 515.318px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.12643);" role="presentation">HPLC method</span></span><span id="page3R_mcid47" class="markedContent"><span dir="ltr" style="left: 854.167px; top: 515.318px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.15065);" role="presentation">s have been</span></span><span id="page3R_mcid48" class="markedContent"><br role="presentation"><span dir="ltr" style="left: 94.4px; top: 530.918px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.18477);" role="presentation">reported for</span></span><span id="page3R_mcid49" class="markedContent"></span><span id="page3R_mcid50" class="markedContent"> <span dir="ltr" style="left: 175.833px; top: 530.918px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.16121);" role="presentation">the determination of antihypertensive drugs. The review</span></span><span id="page3R_mcid51" class="markedContent"></span><span id="page3R_mcid52" class="markedContent"> <span dir="ltr" style="left: 546.517px; top: 530.918px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.1544);" role="presentation">familiarizes various reported methods for the simultaneous</span></span><span id="page3R_mcid53" class="markedContent"><br role="presentation"><span dir="ltr" style="left: 94.4px; top: 546.518px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.18284);" role="presentation">determination of</span></span><span id="page3R_mcid54" class="markedContent"></span><span id="page3R_mcid55" class="markedContent"> <span dir="ltr" style="left: 208.633px; top: 546.518px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.1457);" role="presentation">Amlodipine</span></span><span id="page3R_mcid56" class="markedContent"></span><span id="page3R_mcid57" class="markedContent"> <span dir="ltr" style="left: 287.433px; top: 546.518px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.14217);" role="presentation">besylate with</span></span><span id="page3R_mcid58" class="markedContent"></span><span id="page3R_mcid59" class="markedContent"> <span dir="ltr" style="left: 379.683px; top: 546.518px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.18525);" role="presentation">other antihypertensive drug</span></span><span id="page3R_mcid60" class="markedContent"></span><span id="page3R_mcid61" class="markedContent"> <span dir="ltr" style="left: 568.917px; top: 546.518px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.1873);" role="presentation">formulations which are used in combination tre</span></span><span id="page3R_mcid62" class="markedContent"><span dir="ltr" style="left: 887.367px; top: 546.518px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.15676);" role="presentation">atment</span></span><span id="page3R_mcid63" class="markedContent"><br role="presentation"><span dir="ltr" style="left: 94.4px; top: 562.318px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.11972);" role="presentation">protocols.</span></span><span id="page3R_mcid64" class="markedContent"></span><span id="page3R_mcid65" class="markedContent"><br role="presentation"><span dir="ltr" style="left: 94.4px; top: 587.918px; font-size: 13.4px; font-family: sans-serif; transform: scaleX(1.17876);" role="presentation"><br></span></span><span id="page3R_mcid67" class="markedContent"> </span></p> 2022-08-15T13:47:02+0530 ##submission.copyrightStatement## A Short Review on Cefueoxime Axetil Tablet 2022-08-15T14:18:32+0530 Sanjay Kumar Kamal Jeet Anjana Devi Pankaj Kumar Nishant Kumar <p>Cefuroxime axetil is a broad-spectrum antibiotic with a simple pharmacokinetic profile. The medicine treats otitis media, pharyngitis, sinusitis, CAP, and acute exacerbations of chronic bronchitis effectively and well. Cefuroxime axetil was beneficial in intravenous/oral sequential therapy for CAP, but dosage recommendations are not accessible in some countries. Cefuroxime axetil may be used to treat community-acquired infections, including those caused by -lactamase-producing respiratory bacteria. In an era of rapidly growing bacterial resistance, empirical treatment with cefuroxime axetil may assure the proper use of newer antibacterial medicines, reducing bacterial resistance to these drugs.</p> <p>&nbsp;</p> 2022-08-14T22:28:16+0530 ##submission.copyrightStatement## Review on Collagen as a wound healer. 2022-08-15T14:18:32+0530 Tribhuvan G.S Velhal A B Jadhav. P D Redasani V K <p>In reaction to the tissue injury, normal wound healing process goes through inflammatory, proliferative, and remodeling stages. Impairments any one of these stages cause the wound to become chronic and non-healing, necessitating intervention to bring returning the process to its original state. Collagen, a fundamental has a role in the matrix extracellular an important function in wound healing regulation, whether in its native fibrillar form or&nbsp;in&nbsp;the&nbsp;wound&nbsp;as&nbsp;soluble&nbsp;components environment. Collagen has been used as an additional wound treatment to aid healing since it is involved in the control a combination of a few of these processes. The importance of collagen in various biological processes related to wound healing is discussed in this paper, additionally to a survey of the existing research in regards to the utilization of collagen-based wound care. There are several techniques to developing recommendations, but no gold standard has emerged so till now.</p> <p>&nbsp;</p> <p><em>&nbsp;</em></p> <p>&nbsp;</p> <p><strong><em>&nbsp;</em></strong></p> 2022-08-14T22:30:57+0530 ##submission.copyrightStatement## Review on process validation of Amoxicillin Potassium Clavulanate Dry Syrup 2022-08-15T14:18:32+0530 Anjana Devi Sanjay Kumar Kamal Jeet Vikash Sharma Aman Chaudhary <p>Modern medicines for human use are required to comply with specific standards and regulation set forth by the concerned authorities. A simple and sensitive UV spectrophotometric method was developed and validated for the simultaneous determination of Potassium Clavulanate (PC) and Amoxicillin. &nbsp;As complementary of this work, an assay method for amoxicillin and potassium clavulanate mixtures was developed and validated; stress-testing and stability studies of amox/clav mixtures was carried out under specified conditions according to ICH and analyzed by using validated stability-indicating assay and related substances methods. Aim of this study was to test the validation of derivative spectrophotometric method in simultaneous determination the content amoxicillin and clavulanate potassium in dry syrup by derivative spectrophotometric method with zero crossing technique, in buffer phosphate pH 4,4-methanol (91:9) mixture.</p> <p><strong>&nbsp;</strong></p> <p><strong>&nbsp;</strong></p> 2022-08-14T22:32:23+0530 ##submission.copyrightStatement## A Comprehensive Review on Amoxicilin and Clavulanic Acid as Potential Antibacterial Agent 2022-08-15T14:18:32+0530 Kamal Jeet Sanjay Kumar Gajender Singh Rajat Jaswal Dikshit Kumar Amit Thakur <p>Suspensions comprise finely divided medication particles (the suspensoid) spread uniformly in a vehicle with or without stabilisers and other ingredients. Conventional oral suspension is ready-to-use and does not require reconstitution. Dry syrup is more bioavailable than tablets and capsules because it dissolves in water outside the mouth and enters the GI tract. GIT absorbs suspension quickly: Amoxicillin and clavulanic acid have been used since the 1970s. Despite having the same half-life as amoxicillin, clavulanic acid is protein-bound and heat unstable. It causes gastrointestinal side effects, including Clostridium difficile infection, and restricts amoxicillin oral combination doses. Due to clavulanic acid's b-lactamase tendency, the first amoxicillineclavulanic acid ratio was 4:1; currently it's 2:1, 7:1, 14:1, and 16:1. Few ratio comparisons exist. Amoxicillineclavulanic acid is often used as empiric therapy for WHO's Priority Infectious Syndromes in adults and children, resulting in large consumption. Some of these syndromes may be handled with a delayed antibiotic prescription approach or amoxicillin alone.</p> 2022-08-14T22:34:46+0530 ##submission.copyrightStatement##