TY - JOUR AU - Nessa, Nessa AU - Putri, Noni Rahayu AU - Fitrianda, Eka AU - Elmitra, Elmitra AU - Asra, Ridho PY - 2020/12/15 Y2 - 2024/03/29 TI - Effect of Gel Formulation of Corn Silk Extract (Stigma Maydis) On Burn Wound Healing In Male White Rat JF - Asian Journal of Pharmaceutical Research and Development JA - Asian J Pharm Res Dev VL - 8 IS - 6 SE - Research Articles DO - 10.22270/ajprd.v8i6.821 UR - https://ajprd.com/index.php/journal/article/view/821 SP - 20-27 AB - <p><strong>Objectives:</strong> Burns are damage or loss of tissue caused by exposure to very high temperatures. This study was to determine the effect of gel formulation from corn silk (<em>Stigma maydis</em>) in healing burns in male white rats.</p><p><strong>Data Sources Study Selection</strong>: This research is an experimental research of the effect of gel formulation from corn silk (<em>Stigma maydis</em>) in healing burns in male white rats</p><p><strong>Summary of contents of the article:</strong> Five groups are used in this study. Group I (induced hot metal), group II (induced hot metal + gel base), group III (induced hot metal + 10% corn silk extract gel), group IV (induced hot metal + 15% gel of corn silk extract gel), group V (induced hot metal + B® gel). Observations were made for 21 days. The results of this study are the average % of burns healing on day 7, 14 and 21 : group I (27.29%, 63.03%, 100%), group II (35.39%, 60.16 %, 100%), group III (37.16%, 65.34%, 100%), group IV (36.89%, 68.23%, 100%), group V (32.81%, 66, 48%, 100%). The period of epithelialization of skin tissue are groups I, II, III on day 16, group IV on day 14 and group V on day 17. The mean results of the epithelialization scores for groups I, II, III, IV and V (2, 2, 3, 3, 3), the mean fibroblast score results (2,7, 2,9, 3, 3, 3), groups I, II, III, IV and V collagen fiber density groups I, II, III , IV and V (2,2, 2,8, 3,6, 3,9, 3,9). The two-way ANOVA statistical analysis test on % burn healing was not significant (p&gt; 0.05), and the one-way ANOVA statistical analysis test at the period of epithelialization was not significant (p&gt;0.05) and the histology of epithelialization and fibroblasts was not significant (p&gt;0.05), the density of collagen fibers was significant (p&lt;0.05).</p><p><strong>Conclusion</strong>: The conclusion of this study is corn silk extract gel (<em>Stigma maydis</em>) 10% and 15% have the effect on the healing process of burns and can be formulated in gel dosage forms.</p> ER -